INT127647

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Context Info
Confidence 0.07
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.28
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Wnt7a) extracellular space (Wnt7a) extracellular region (Wnt7a)
proteinaceous extracellular matrix (Wnt7a) plasma membrane (Wnt7a) cell-cell signaling (Wnt7a)
Wnt7a (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 6 91.56 High High
Pain score 2 86.80 High High
COX-2 inhibitor 2 81.08 Quite High
cINOD 4 75.92 Quite High
Pain 4 71.92 Quite High
COX2 2 25.00 Low Low
cOX1 2 25.00 Low Low
anesthesia 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Poisoning 8 96.68 Very High Very High Very High
Knee Osteoarthritis 4 91.56 High High
Osteoarthritis 2 89.04 High High
Pain 6 86.80 High High
Stress 8 82.60 Quite High
INFLAMMATION 2 75.36 Quite High
Injury 3 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Hepatotoxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Celecoxib-treated patients had significant decrease in nitrite levels (p = 0.043), whereas SOD, XO, GSH-Px enzyme activities, and MDA levels did not change significantly compared to baseline.
Neg (not) Regulation (change) of GSH-Px enzyme
1) Confidence 0.07 Published 2005 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15943176 Disease Relevance 0.57 Pain Relevance 0.49
Pretreatment with Mn2+ prevented the effect of cadmium on GSH-Px activity and significantly attenuated the inhibition of CAT activity caused by Cd-intoxication.
Regulation (effect) of GSH-Px associated with poisoning
2) Confidence 0.05 Published 2010 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2984133 Disease Relevance 0.10 Pain Relevance 0
Tenoxicam-treated patients had significant decrease in nitrite levels (p = 0.036) and XO activity (p = 0.01), but their SOD, GSH-Px enzyme activities, and MDA levels were unchanged from baseline.
Neg (unchanged) Regulation (unchanged) of GSH-Px enzyme
3) Confidence 0.04 Published 2005 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15943176 Disease Relevance 0.61 Pain Relevance 0.52

General Comments

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