INT127649

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.21
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Ifih1) nucleus (Ifih1) intracellular (Ifih1)
helicase activity (Ifih1) DNA binding (Ifih1) cytoplasm (Ifih1)
Ifih1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 24 99.56 Very High Very High Very High
potassium channel 2 98.92 Very High Very High Very High
qutenza 8 95.12 Very High Very High Very High
Analgesic 5 93.28 High High
Osteoarthritis 6 90.36 High High
Pain score 2 86.80 High High
COX-2 inhibitor 2 79.88 Quite High
cINOD 4 74.72 Quite High
Pain 6 71.92 Quite High
cOX1 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 4 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
INFLAMMATION 31 99.56 Very High Very High Very High
Infection 53 99.12 Very High Very High Very High
Pressure And Volume Under Development 6 96.92 Very High Very High Very High
Disease Progression 1 90.48 High High
Knee Osteoarthritis 4 90.36 High High
Osteoarthritis 2 89.04 High High
Pain 6 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example Oas1b, Ifi27, Ifih1 and Irf7 genes were up-regulated at 72 and 96 hr post infection.
Regulation (regulated) of Ifih1 associated with infection
1) Confidence 0.23 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.44 Pain Relevance 0
Celecoxib-treated patients had significant decrease in nitrite levels (p = 0.043), whereas SOD, XO, GSH-Px enzyme activities, and MDA levels did not change significantly compared to baseline.
Neg (not) Regulation (change) of MDA
2) Confidence 0.16 Published 2005 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15943176 Disease Relevance 0.57 Pain Relevance 0.48
MDT also affected the levels of interleukin-1beta, tumor necrosis factor-alpha, NO and MDA which were induced by lambda-carrageenan.
Regulation (affected) of MDA associated with necrosis and cancer
3) Confidence 0.08 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19606516 Disease Relevance 1.34 Pain Relevance 0.59
Tenoxicam-treated patients had significant decrease in nitrite levels (p = 0.036) and XO activity (p = 0.01), but their SOD, GSH-Px enzyme activities, and MDA levels were unchanged from baseline.
Neg (unchanged) Regulation (unchanged) of MDA
4) Confidence 0.08 Published 2005 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15943176 Disease Relevance 0.61 Pain Relevance 0.52
Treatments effects on ethanol-associated oxidative stress markers GSH, MDA, catalase, SOD, and total nitrate/nitrite levels as an index of NO were measured in gastric tissue.
Regulation (effects) of MDA associated with stress
5) Confidence 0.04 Published 2010 Journal Chem. Biol. Interact. Section Abstract Doc Link 19853593 Disease Relevance 0.16 Pain Relevance 0.14
AAs afforded a dose-related gastroprotection against the ethanol damage and further prevented the ethanol-induced changes in the levels of GSH, MDA, catalase, SOD and nitrate/nitrite.
Regulation (changes) of MDA
6) Confidence 0.04 Published 2010 Journal Chem. Biol. Interact. Section Abstract Doc Link 19853593 Disease Relevance 0.09 Pain Relevance 0.19

General Comments

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