INT12765

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Context Info
Confidence 0.66
First Reported 1991
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 59
Total Number 59
Disease Relevance 20.16
Pain Relevance 34.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
thalamus 6
DRGs 6
spinal cord 4
midbrain 4
pyramidal cells 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 793 100.00 Very High Very High Very High
nMDA receptor 206 100.00 Very High Very High Very High
agonist 65 100.00 Very High Very High Very High
Dorsal horn 17 100.00 Very High Very High Very High
Lasting pain 5 99.92 Very High Very High Very High
qutenza 269 99.84 Very High Very High Very High
Peripheral nerve injury 1 99.80 Very High Very High Very High
Abeta 10 99.68 Very High Very High Very High
Endocannabinoid 5 99.66 Very High Very High Very High
nociceptor 29 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 79 100.00 Very High Very High Very High
Pain 244 99.92 Very High Very High Very High
Diabetes Mellitus 129 99.86 Very High Very High Very High
Nervous System Injury 18 99.80 Very High Very High Very High
Diabetic Neuropathy 25 99.60 Very High Very High Very High
Ganglion Cysts 183 99.40 Very High Very High Very High
Cardiovascular Disorder Under Development 1 99.12 Very High Very High Very High
Urological Neuroanatomy 14 98.80 Very High Very High Very High
Injury 51 98.64 Very High Very High Very High
Hepatopulmonary Syndrome 1 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, SP, which is released in the spinal cord subsequent to persistent stimulation of small sensory afferents after tissue injury, may contribute to spinal hyperexcitability and persistent pain by enhancement of PKC-mediated phosphorylation of target molecules such as NMDA receptors.
Positive_regulation (enhancement) of Phosphorylation (phosphorylation) of PKC in spinal associated with pain, kinase c, nmda receptor, lasting pain, injury, hyperexcitability, spinal cord and substance p
1) Confidence 0.66 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986346 Disease Relevance 0.49 Pain Relevance 1.27
We examined the hypothesis that decreased inhibitory G protein function in diabetic neuropathy is associated with increased protein kinase C (PKC)-dependent phosphorylation of the Goalpha subunit.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of PKC associated with kinase c and diabetic neuropathy
2) Confidence 0.63 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887697 Disease Relevance 0.49 Pain Relevance 0.40
Phosphorylation of PKC-alpha was increased, PKC-betaII was unchanged and PKC-delta decreased in diabetic DRGs.
Positive_regulation (increased) of Phosphorylation (Phosphorylation) of PKC in DRGs associated with kinase c and diabetes mellitus
3) Confidence 0.63 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887697 Disease Relevance 0.78 Pain Relevance 0.62
The mechanism of TMP action may be the allosteric regulation via acting on the large extracellular region of ATP receptor-ion channel complex (P2X receptors) and promoting the phosphorylation of PKC site of the N-terminus of P2X receptors.
Positive_regulation (promoting) of Phosphorylation (phosphorylation) of PKC
4) Confidence 0.54 Published 2005 Journal Brain Res. Section Abstract Doc Link 15804430 Disease Relevance 0.07 Pain Relevance 0.04
Thus, tolerance produced by morphine infusion is dependent upon an increase in local phosphorylating activity by PKC.
Positive_regulation (increase) of Phosphorylation (phosphorylating) of PKC associated with kinase c, tolerance and morphine
5) Confidence 0.50 Published 2000 Journal Pain Section Abstract Doc Link 10781912 Disease Relevance 0 Pain Relevance 1.76
I.t. morphine infusion, but not saline, produced a 2-fold increase in dorsal horn PKC phosphorylating activity and in the expression of PKCalpha/gamma.
Positive_regulation (increase) of Phosphorylation (phosphorylating) of PKC in dorsal horn associated with kinase c, dorsal horn and morphine
6) Confidence 0.50 Published 2000 Journal Pain Section Abstract Doc Link 10781912 Disease Relevance 0 Pain Relevance 1.87
These results suggest that painful diabetic neuropathy is associated with altered cell-specific expression of the VR1 receptor that is coupled to increased function through PKC-mediated phosphorylation, oligomerization, and targeted expression on the cell surface membrane.
Positive_regulation (coupled) of Phosphorylation (phosphorylation) of PKC associated with painful diabetic neuropathy and kinase c
7) Confidence 0.49 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15513920 Disease Relevance 1.05 Pain Relevance 0.85
Phosphorylation of NR1 by PKC increases surface expression of NMDA receptors, increases delivery of NMDA receptors to the surface and to the synapse [28,37,38].
Positive_regulation (increases) of Phosphorylation (Phosphorylation) of PKC in synapse associated with kinase c and nmda receptor
8) Confidence 0.48 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482680 Disease Relevance 0.15 Pain Relevance 0.97
Both basal and PKC-mediated labeling of Goalpha with 32Pi was significantly less in DRGs from diabetic rats, supporting increased endogenous PKC-dependent phosphorylation of Goalpha.
Positive_regulation (supporting) of Phosphorylation (phosphorylation) of PKC in DRGs associated with kinase c and diabetes mellitus
9) Confidence 0.46 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887697 Disease Relevance 0.80 Pain Relevance 0.63
Both basal and PKC-mediated labeling of Goalpha with 32Pi was significantly less in DRGs from diabetic rats, supporting increased endogenous PKC-dependent phosphorylation of Goalpha.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of PKC in DRGs associated with kinase c and diabetes mellitus
10) Confidence 0.46 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887697 Disease Relevance 0.80 Pain Relevance 0.63
We examined the hypothesis that decreased inhibitory G protein function in diabetic neuropathy is associated with increased protein kinase C (PKC)-dependent phosphorylation of the Goalpha subunit.
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of PKC associated with kinase c and diabetic neuropathy
11) Confidence 0.42 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12887697 Disease Relevance 0.49 Pain Relevance 0.40
Concurrently, oxaliplatin chronic treatment induced a specific upregulation of gamma isoforms of PKC and increased phosphorylation of gamma/epsilon PKC isoforms within thalamus and PAG.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of PKC in thalamus associated with urological neuroanatomy and thalamus
12) Confidence 0.39 Published 2009 Journal Pain Section Abstract Doc Link 19683395 Disease Relevance 0.86 Pain Relevance 0.57
NMDA receptor phosphorylation by PKA or PKC also accelerates the rise and decay times of the ion channel [69,78], which explains the absence of apparent differences in the kinetics of NMDA EPSC and compound EPSC in the present study.
Positive_regulation (accelerates) of Phosphorylation (phosphorylation) of PKC associated with nmda receptor
13) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.32 Pain Relevance 0.60
However, treatment with taurine markedly suppressed this As-induced phosphorylation of PKC?.
Positive_regulation (-) of Phosphorylation (phosphorylation) of PKC associated with kinase c
14) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.40 Pain Relevance 0.66
We observed that rottlerin reduced As-induced phosphorylation of PKC?
Positive_regulation (induced) of Phosphorylation (phosphorylation) of PKC
15) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.26 Pain Relevance 0
Concurrently, oxaliplatin chronic treatment induced a specific upregulation of gamma isoforms of PKC and increased phosphorylation of gamma/epsilon PKC isoforms within thalamus and PAG.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of PKC in thalamus associated with urological neuroanatomy and thalamus
16) Confidence 0.37 Published 2009 Journal Pain Section Abstract Doc Link 19683395 Disease Relevance 0.86 Pain Relevance 0.57
Concurrently, oxaliplatin chronic treatment induced a specific upregulation of gamma isoforms of PKC and increased phosphorylation of gamma/epsilon PKC isoforms within thalamus and PAG.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of PKC in thalamus associated with urological neuroanatomy and thalamus
17) Confidence 0.37 Published 2009 Journal Pain Section Abstract Doc Link 19683395 Disease Relevance 0.85 Pain Relevance 0.57
Moreover phosphorylation of ERK and PKC was induced by epinephrine, and ERK and PKC specific inhibitors concentration-dependently prevented epinephrine-induced phosphorylation of MAP-2c at ser136.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of PKC
18) Confidence 0.34 Published 2008 Journal J. Proteome Res. Section Abstract Doc Link 18290605 Disease Relevance 0.07 Pain Relevance 0.26
The dose-dependent ropivacaine-induced phosphorylation of PKC and p44/42 MAPK and the membrane translocation of Rho kinase were also detected using Western blotting.
Positive_regulation (ropivacaine-induced) of Phosphorylation (phosphorylation) of PKC
19) Confidence 0.34 Published 2005 Journal Anesthesiology Section Body Doc Link 16129980 Disease Relevance 0 Pain Relevance 0
Ropivacaine also induced an increase in phosphorylation of PKC and p44/42 MAPK, and membrane translocation of Rho kinase in accordance with the contractile responses, which were also significantly inhibited by bisindolylmaleimide I and calphostin C, Y 27632, and PD 098059, correspondingly.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of PKC
20) Confidence 0.34 Published 2005 Journal Anesthesiology Section Body Doc Link 16129980 Disease Relevance 0 Pain Relevance 0

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