INT127654

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 13.70
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (XRCC1) nucleus (XRCC1) intracellular (XRCC1)
Anatomy Link Frequency
kidney 2
XRCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 5 86.16 High High
imagery 20 72.24 Quite High
cva 9 64.24 Quite High
abdominal pain 4 55.44 Quite High
palliative 5 51.88 Quite High
Angina 4 32.40 Quite Low
withdrawal 4 31.88 Quite Low
Crohn's disease 4 24.72 Low Low
Pain 33 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cancer 384 100.00 Very High Very High Very High
Carcinoma 192 100.00 Very High Very High Very High
Disease 172 100.00 Very High Very High Very High
Pheochromocytoma 16 100.00 Very High Very High Very High
Renal Cell Carcinoma 8 100.00 Very High Very High Very High
Cancer 374 99.84 Very High Very High Very High
Fever 7 99.64 Very High Very High Very High
Jaundice 4 99.28 Very High Very High Very High
Thyroid Neoplasm 4 97.52 Very High Very High Very High
Hematuria 24 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While these questionnaires were designed to assess HRQL among cancer patients, these measures are not specific to RCC or kidney cancer overall.
Positive_regulation (overall) of Gene_expression (overall) of RCC in kidney associated with cancer and renal cancer
1) Confidence 0.38 Published 2007 Journal Health Qual Life Outcomes Section Body Doc Link PMC1929060 Disease Relevance 1.54 Pain Relevance 0
Volpe et al. showed that papillary RCC incidence
Positive_regulation (papillary) of Gene_expression (incidence) of RCC associated with carcinoma
2) Confidence 0.17 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2629071 Disease Relevance 2.09 Pain Relevance 0
Aggressive potential of small RCC could increase in tumors greater than 3 cm, so it is suggested that
Positive_regulation (increase) of Gene_expression (potential) of RCC associated with cancer and carcinoma
3) Confidence 0.17 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2629071 Disease Relevance 1.08 Pain Relevance 0
Aggressive potential of small RCC could increase in tumors greater than 3 cm, so it is suggested that
Positive_regulation (potential) of Gene_expression (potential) of RCC associated with cancer and carcinoma
4) Confidence 0.17 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2629071 Disease Relevance 1.07 Pain Relevance 0
manifestations of RCC such as fever or jaundice are extremely rare in front of
Positive_regulation (manifestations) of Gene_expression (manifestations) of RCC associated with carcinoma, jaundice and fever
5) Confidence 0.17 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2629071 Disease Relevance 2.05 Pain Relevance 0.06
entire VHL spectrum, including pheochromocytomas with or without RCC, called
Positive_regulation (called) of Gene_expression (spectrum) of RCC associated with pheochromocytoma
6) Confidence 0.08 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.66 Pain Relevance 0
entire VHL spectrum, including pheochromocytomas with or without RCC, called
Positive_regulation (entire) of Gene_expression (spectrum) of RCC associated with pheochromocytoma
7) Confidence 0.08 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.66 Pain Relevance 0
Herein is presented a case of RCC possessing the chromophobe RCC and CDC elements occurring in a 64 year-old Japanese woman.
Positive_regulation (presented) of Gene_expression (possessing) of RCC associated with carcinoma and renal cell carcinoma
8) Confidence 0.07 Published 2005 Journal Pathol. Int. Section Abstract Doc Link 15943794 Disease Relevance 1.44 Pain Relevance 0.12
This suggests that limited clinical experience of IFN use in RCC and thus of management of IFN-related toxicities may in part be responsible for the higher incidence of grade 3/4 toxicity with IFN in CALGB 90206.
Positive_regulation (experience) of Gene_expression (use) of RCC associated with toxicity and renal cancer
9) Confidence 0.05 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721410 Disease Relevance 0.85 Pain Relevance 0
RCC: disease overview
Positive_regulation (overview) of Gene_expression (overview) of RCC associated with renal cancer and disease
10) Confidence 0.05 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721410 Disease Relevance 1.49 Pain Relevance 0.04
A substantial study of 375 patients investigated the prognostic significance of mTOR pathway components in tumors obtained at nephrectomy, and observed adverse prognostic impact on disease-specific survival of pS6K, PTEN and Akt independent of stage.73 A small study further suggested that pS6K and possibly Akt were predictors of response to temsirolimus for advanced RCC.67,74 However an extension of the study20 of temsirolimus for poor prognosis advanced RCC did not find a correlation between PTEN and HIF-1?
Positive_regulation (advanced) of Gene_expression (extension) of RCC associated with cancer, renal cancer and disease
11) Confidence 0.02 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880340 Disease Relevance 0.78 Pain Relevance 0.05

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