INT127668

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 8.39
Pain Relevance 5.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4A) signal transduction (PDE4A) plasma membrane (PDE4A)
nucleus (PDE4A) cytoplasm (PDE4A)
Anatomy Link Frequency
macrophages 1
lymphocytes 1
fibroblasts 1
neutrophils 1
PDE4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 288 99.98 Very High Very High Very High
agonist 78 99.90 Very High Very High Very High
Inflammation 282 99.48 Very High Very High Very High
Potency 5 99.32 Very High Very High Very High
cytokine 75 99.12 Very High Very High Very High
chemokine 18 93.16 High High
Inflammatory mediators 14 92.24 High High
adenocard 10 92.16 High High
bradykinin 123 90.00 High High
Inflammatory response 15 89.96 High High
Disease Link Frequency Relevance Heat
Pulmonary Disease 287 99.84 Very High Very High Very High
INFLAMMATION 351 99.48 Very High Very High Very High
Asthma 70 97.04 Very High Very High Very High
Disease 100 95.44 Very High Very High Very High
Nicotine Addiction 86 95.20 Very High Very High Very High
Hypertension 8 93.56 High High
Reprotox - General 2 8 92.44 High High
Heart Disease 4 91.56 High High
Dysmenorrhea 6 84.56 Quite High
Premature Birth 38 78.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, PDE4 activity was independently increased by LPS treatment.
Positive_regulation (increased) of PDE4
1) Confidence 0.68 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892053 Disease Relevance 0.35 Pain Relevance 0.26
Functionally, augmentation of global PDE4 activity decreases the ability of ?
Positive_regulation (augmentation) of PDE4
2) Confidence 0.68 Published 2007 Journal BMC Pregnancy Childbirth Section Abstract Doc Link PMC1892053 Disease Relevance 0.79 Pain Relevance 0.36
We found that PDE4 family is the major cAMP-PDE expressed in human fetal membranes and that PDE4 activity is increased by LPS treatment.
Positive_regulation (increased) of PDE4
3) Confidence 0.50 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15944316 Disease Relevance 0.78 Pain Relevance 0.49
We found that PDE4 family is the major cAMP-PDE expressed in human fetal membranes and that PDE4 activity is increased by LPS treatment.
Positive_regulation (increased) of PDE4
4) Confidence 0.50 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15944316 Disease Relevance 0.76 Pain Relevance 0.48
PDE4 is the largest PDE family known to date, encoded by four distinct genes, PDE4A-D, and generating more than 20 different isoforms in mammals by means of differential promoters and splicing.
Positive_regulation (generating) of PDE4
5) Confidence 0.46 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892053 Disease Relevance 0.38 Pain Relevance 0.05
Hence, PDE4 upregulation provides a feedback mechanism by which cells might adapt from sustained stimulation of the cAMP pathway.
Positive_regulation (upregulation) of PDE4
6) Confidence 0.46 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892053 Disease Relevance 0.12 Pain Relevance 0.19
PDE4 is a cAMP specific phosphodiesterase which is located predominantly to inflammatory cells, including cells important to the pathogenesis of COPD such as neutrophils, macrophages, lymphocytes, fibroblasts and airway smooth muscle.
Positive_regulation (located) of PDE4 in fibroblasts associated with pulmonary disease and inflammation
7) Confidence 0.46 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.86 Pain Relevance 0.38
PDE4: relevance to COPD
Positive_regulation (relevance) of PDE4 associated with pulmonary disease
8) Confidence 0.46 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.97 Pain Relevance 0.52
Reports of a role for PDE4 inhibitors in asthma and COPD treatment [14] together with the known interactions between the MAPK and cAMP pathways [16,17] lead to our interest for possible nicotine-induced changes in PDE4 and cAMP pathway.
Spec (possible) Positive_regulation (induced) of PDE4 associated with asthma, pulmonary disease and nicotine
9) Confidence 0.25 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.59 Pain Relevance 0.33
The whole process depends on the activation of JNK- and PDE4-related intracellular signal pathways Thus, our findings might provide new therapeutic targets for future treatment of tobacco smoke-associated AHR.


Positive_regulation (activation) of PDE4 associated with nicotine addiction
10) Confidence 0.23 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.10 Pain Relevance 0.30
Nicotine enhances murine airway contractile responses to kinin receptor agonists via activation of JNK- and PDE4-related intracellular pathways

Background

Positive_regulation (activation) of PDE4 associated with nicotine and agonist
11) Confidence 0.23 Published 2010 Journal Respir Res Section Title Doc Link PMC2845563 Disease Relevance 0.10 Pain Relevance 0.63
PDE4 is a cAMP specific phosphodiesterase which is located predominantly to inflammatory cells, including cells important to the pathogenesis of COPD such as neutrophils, macrophages, lymphocytes, fibroblasts and airway smooth muscle.
Positive_regulation (located) of PDE4 in lymphocytes associated with pulmonary disease and inflammation
12) Confidence 0.16 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.86 Pain Relevance 0.38
PDE4 is a cAMP specific phosphodiesterase which is located predominantly to inflammatory cells, including cells important to the pathogenesis of COPD such as neutrophils, macrophages, lymphocytes, fibroblasts and airway smooth muscle.
Positive_regulation (located) of PDE4 in macrophages associated with pulmonary disease and inflammation
13) Confidence 0.16 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.86 Pain Relevance 0.38
PDE4 is a cAMP specific phosphodiesterase which is located predominantly to inflammatory cells, including cells important to the pathogenesis of COPD such as neutrophils, macrophages, lymphocytes, fibroblasts and airway smooth muscle.
Positive_regulation (located) of PDE4 in neutrophils associated with pulmonary disease and inflammation
14) Confidence 0.16 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.86 Pain Relevance 0.38

General Comments

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