INT127669

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.74
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE4A) signal transduction (PDE4A) plasma membrane (PDE4A)
nucleus (PDE4A) cytoplasm (PDE4A)
Anatomy Link Frequency
lung 2
PDE4A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 18 99.68 Very High Very High Very High
Inflammation 60 99.32 Very High Very High Very High
Inflammatory response 5 83.60 Quite High
rheumatoid arthritis 15 83.36 Quite High
metalloproteinase 2 75.00 Quite High
Arthritis 47 73.04 Quite High
Dismenorea 1 69.88 Quite High
abdominal pain 1 55.76 Quite High
dexamethasone 4 50.40 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 79 99.32 Very High Very High Very High
Nicotine Addiction 15 98.88 Very High Very High Very High
Pulmonary Disease 191 98.60 Very High Very High Very High
Rupture 2 98.44 Very High Very High Very High
Death 2 90.20 High High
Disease 37 86.36 High High
Emphysema 8 84.08 Quite High
Rheumatoid Arthritis 15 83.36 Quite High
Vomiting 18 76.12 Quite High
Arthritis 44 73.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDE4 inhibition reduced cyclooxygenase-2 protein expression and PGE(2) production and also modulated MMP-9, a key mediator of the membrane rupture process, by inhibiting pro-MMP-9 mRNA expression and pro-MMP-9 activity.
Regulation (modulated) of Negative_regulation (inhibition) of PDE4 associated with rupture
1) Confidence 0.45 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15944316 Disease Relevance 0.75 Pain Relevance 0.48
The proposed role of macrophage derived MMP12 in the emphysematous changes to the lung in chronic smoking models in mice (Shapiro et al 2003) would suggest that PDE4 inhibitors will be ineffective at inhibiting emphysematous changes to the lung.
Regulation (ineffective) of Negative_regulation (inhibitors) of PDE4 in lung associated with nicotine addiction
2) Confidence 0.41 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 0.56 Pain Relevance 0.07
In accordance with our findings, several other PDE4 inhibitors have been reported to have minimal effects on IL-6 in human PBMC, while potently inhibiting both TNF?
Regulation (reported) of Negative_regulation (inhibitors) of PDE4
3) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911898 Disease Relevance 0.39 Pain Relevance 0.18
The effect of PDE4 inhibitors on health status in patients with COPD is variable possibly due to differences in the duration of treatment (Compton et al 2001; Rabe et al 2005; Rennard et al 2006).
Regulation (effect) of Negative_regulation (inhibitors) of PDE4 associated with pulmonary disease
4) Confidence 0.13 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707800 Disease Relevance 1.03 Pain Relevance 0.16

General Comments

This test has worked.

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