INT127670

Context Info Confidence 0.54 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 1.75 Pain Relevance 1.33

lysosome (ARSD)

Anatomy Link Frequency external 1 eye field 1 ARSD (Homo sapiens)

Pain Link Frequency Relevance Heat Anterior cingulate cortex 249 100.00 depression 8 95.76 Osteoarthritis 49 94.28 Inflammation 18 92.92 rheumatoid arthritis 68 91.76 Neuropeptide 11 77.36 imagery 75 76.88 Anterior cingulate 3 75.00 cINOD 6 64.88 Leflunomide 5 64.16

Disease Link Frequency Relevance Heat Genetic Predisposition To Disease 1 96.88 Depression 8 95.76 Frailty 50 94.28 INFLAMMATION 18 92.92 Rheumatoid Arthritis 68 91.76 Congenital Anomalies 43 86.80 Autism 92 82.60 Traumatic Stress Disorders 1 75.52 Post-traumatic Stress Disorder 1 74.24 Asperger Syndrome 5 72.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Regions of greater activation in controls are depicted in warm colours; greater activation in ASD patients is depicted in blue.

Positive_regulation (activation) of ASD

1) Confidence 0.54 Published 2008 Journal Brain Section Body Doc Link PMC2525446 Disease Relevance 0 Pain Relevance 0.03

Rather unexpected are the low scores on the „physical health“ domain, as physical impairment is no key component of ASD.

Positive_regulation (component) of ASD

2) Confidence 0.43 Published 2010 Journal GMS Psycho-Social-Medicine Section Body Doc Link PMC2940215 Disease Relevance 0.17 Pain Relevance 0.05

All patients underwent standard ASD.

Positive_regulation (underwent) of ASD

3) Confidence 0.39 Published 2005 Journal Arthroscopy Section Body Doc Link 15944622 Disease Relevance 0 Pain Relevance 0

Thus, in ASD, aberrant communication between response evaluation in the ACC and regions initiating compensatory adjustments, possibly lateral prefrontal cortex, could result in a failure to optimally reduce preparatory firing rates in frontal eye field in response to a prior error.

Positive_regulation (result) of ASD in eye field associated with anterior cingulate cortex

4) Confidence 0.36 Published 2008 Journal Brain Section Body Doc Link PMC2525446 Disease Relevance 0 Pain Relevance 0.13

Finally, in ASD (v) increased activation on correct trials and reduced FA in rACC WM were related to higher ratings of repetitive behaviour.

Positive_regulation (increased) of ASD

5) Confidence 0.36 Published 2008 Journal Brain Section Abstract Doc Link PMC2525446 Disease Relevance 0.43 Pain Relevance 0.44

However, our working hypothesis is that ASD can be caused or influenced by external events in early childhood, possibly as result of a genetic predisposition.

Positive_regulation (caused) of ASD in external associated with genetic predisposition to disease

6) Confidence 0.35 Published 2005 Journal BMC Psychiatry Section Body Doc Link PMC1190193 Disease Relevance 0.46 Pain Relevance 0.23

DHEA is the major delta 5 androgen (Fig. 1), which is converted to androstenediol, ASD, 16?

Positive_regulation (converted) of ASD

7) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 0.69 Pain Relevance 0.44

CONCLUSIONS: In this small study, both dexmedetomidine and ketamine in combination with propofol were well tolerated in these pediatric patients who required ASD closure.

Positive_regulation (required) of ASD

8) Confidence 0.04 Published 2010 Journal Clin Ther Section Body Doc Link 20435239 Disease Relevance 0 Pain Relevance 0

General Comments

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