INT127679

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 4.98
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NGFR) endosome (NGFR) nucleoplasm (NGFR)
cytoplasm (NGFR) signal transducer activity (NGFR) cytosol (NGFR)
Anatomy Link Frequency
synovium 2
NGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 26 100.00 Very High Very High Very High
backache 2 93.28 High High
rheumatoid arthritis 17 91.72 High High
palliative 2 90.28 High High
Pain 7 87.24 High High
cINOD 4 50.00 Quite Low
cytokine 3 50.00 Quite Low
Inflammation 19 49.12 Quite Low
Arthritis 28 30.32 Quite Low
COX2 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Stomach Cancer 5 99.82 Very High Very High Very High
Pancreatic Cancer 16 99.34 Very High Very High Very High
Aggression 3 98.68 Very High Very High Very High
Malignant Neoplastic Disease 4 98.24 Very High Very High Very High
Cancer 89 98.08 Very High Very High Very High
Apoptosis 7 97.76 Very High Very High Very High
Ovarian Cancer 41 96.40 Very High Very High Very High
Pressure And Volume Under Development 20 93.80 High High
Low Back Pain 2 93.28 High High
Solid Tumor 16 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All the drugs tested induced an up-regulation in p75 NTR tumor suppressor gene expression in concert with their observed growth inhibiting ability.
Positive_regulation (induced) of Gene_expression (expression) of p75 NTR
1) Confidence 0.67 Published 2008 Journal Cancer Chemother. Pharmacol. Section Body Doc Link 17447067 Disease Relevance 0 Pain Relevance 0
The co-expression of both NGF receptors, p75(NGFR) and tropomyosin-related kinase A (trkA), represents a crucial condition for the antiproliferative effect of NGF; indeed, p75(NGFR) is progressively lost during prostate tumorigenesis and its disappearance represents a malignancy marker of prostate adenocarcinoma (PCa).
Positive_regulation (represents) of Gene_expression (co-expression) of NGFR associated with malignant neoplastic disease, nerve growth factor and prostate cancer
2) Confidence 0.43 Published 2010 Journal Growth Factors Section Abstract Doc Link 20166899 Disease Relevance 0.65 Pain Relevance 0.38
Conversely, we also found that elevated p75NGFR expression is associated with a favorable prognosis; we demonstrated that NGF exerts both stimulatory and inhibitory effects on pancreatic cancers with the effect based on the expression levels and the ratio of TrkA and p75NGFR.
Positive_regulation (elevated) of Gene_expression (expression) of p75NGFR associated with nerve growth factor and pancreatic cancer
3) Confidence 0.29 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15944784 Disease Relevance 1.08 Pain Relevance 0.38
Detection of CD271 as a specific marker for a stromal subpopulation in the synovium and in expanded cells
Positive_regulation (marker) of Gene_expression (Detection) of CD271 in synovium
4) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.16 Pain Relevance 0.08
About 20 % of gastric cancers exhibit overexpression of the growth factor receptor family member Her2.
Positive_regulation (overexpression) of Gene_expression (overexpression) of growth factor receptor associated with stomach cancer
5) Confidence 0.20 Published 2010 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 20721843 Disease Relevance 0.65 Pain Relevance 0.09
It appears that in pancreatic cancer cells the growth effects of NGF depend on the expression levels and the ratio of TrkA and p75NGFR.
Spec (appears) Positive_regulation (depend) of Gene_expression (expression) of p75NGFR associated with nerve growth factor and pancreatic cancer
6) Confidence 0.19 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15944784 Disease Relevance 1.11 Pain Relevance 0.50
In contrast, expression of CD95 (Figure 4D), TNFR1 or NGFR (data not shown) did not promote Trx1 interactions with the cell surface, further strengthening the notion that Trx1 reactivity is a specific property of CD30.
Neg (not) Positive_regulation (promote) of Gene_expression (expression) of NGFR
7) Confidence 0.16 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.10 Pain Relevance 0
The overexpression of this growth factor receptor alone was shown to be sufficient to induce malignant transformation and is implicated in ovarian cancer as well as many other types of cancer [64-67].
Positive_regulation (overexpression) of Gene_expression (overexpression) of growth factor receptor associated with malignant neoplastic disease, cancer and ovarian cancer
8) Confidence 0.01 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 1.24 Pain Relevance 0

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