INT127681

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.79
Pain Relevance 4.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a6) enzyme binding (Ugt1a6) protein complex (Ugt1a6)
Anatomy Link Frequency
CAR 1
spinal cord 1
small intestine 1
Ugt1a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 57 99.96 Very High Very High Very High
adenocard 179 99.90 Very High Very High Very High
Spinal cord 8 99.48 Very High Very High Very High
cocaine 13 99.42 Very High Very High Very High
Gabapentin 54 99.24 Very High Very High Very High
Dorsal horn 2 99.18 Very High Very High Very High
Analgesic 10 99.08 Very High Very High Very High
Opioid 9 95.44 Very High Very High Very High
Antinociceptive 13 91.76 High High
agonist 139 87.52 High High
Disease Link Frequency Relevance Heat
Sleep Disorders 111 91.16 High High
Nociception 9 86.32 High High
INFLAMMATION 14 84.00 Quite High
Drug Dependence 1 58.24 Quite High
Pain 5 56.72 Quite High
Neuropathic Pain 21 50.00 Quite Low
Toxicity 8 50.00 Quite Low
Metastasis 1 48.24 Quite Low
Apoptosis 2 47.64 Quite Low
Pressure And Volume Under Development 9 44.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No significant cocaine-induced change was found in A1 or A2A receptor binding in any region analyzed.
A1 Binding (binding) of associated with cocaine
1) Confidence 0.47 Published 2005 Journal Synapse Section Abstract Doc Link 15945065 Disease Relevance 0.06 Pain Relevance 1.13
Taken together, these results indicate that nutritional status may gender-specifically influence the expression and activation of CAR and PPARalpha in liver cell nuclei, and this effect appears to be associated with alterations in UGT1A1 and UGT1A6 expression.
UGT1A6 Binding (alterations) of in CAR
2) Confidence 0.32 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 17967931 Disease Relevance 0 Pain Relevance 0.26
Adenosine may interact with at least four subtipes of receptors coupled with protein G, namely A1, A2a, A2b, and A3[16].
A1 Binding (interact) of associated with adenocard
3) Confidence 0.15 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC56902 Disease Relevance 0.28 Pain Relevance 0.86
However, the fact that the receptors for the sensory component are mainly located in the dorsal horn of spinal cord and that there may be an interaction of the A1 receptor with the gabapentin receptor shows the possibility of a functional receptor interaction.
A1 Binding (interaction) of in spinal cord associated with dorsal horn, gabapentin and spinal cord
4) Confidence 0.12 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526387 Disease Relevance 0.32 Pain Relevance 0.52
Using either ligand binding, functional studies, or molecular techniques, A1, A2A, A2B, and A3 receptors have been identified within the rat small intestine [7-10].
A1 Binding (binding) of in small intestine
5) Confidence 0.11 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC139982 Disease Relevance 0 Pain Relevance 0.37
In support, caffeine acts as an AD receptor antagonist, binds to the A1 and A2A receptors [49], but exerts its arousal effect mainly via the latter [135].
A1 Binding (binds) of associated with adenocard and antagonist
6) Confidence 0.04 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.12 Pain Relevance 0.54
A1 receptor
A1 Binding (receptor) of
7) Confidence 0.02 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0 Pain Relevance 0.32

General Comments

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