INT127684

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.19
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Kdr) plasma membrane (Kdr) nucleus (Kdr)
cytoplasm (Kdr)
Anatomy Link Frequency
plasma 1
retinas 1
Kdr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 11 99.12 Very High Very High Very High
Hippocampus 2 87.84 High High
Pain 1 79.16 Quite High
Angina 3 50.00 Quite Low
fibrosis 15 15.24 Low Low
imagery 12 5.00 Very Low Very Low Very Low
corticosteroid 7 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 148 99.60 Very High Very High Very High
Cancer 74 98.96 Very High Very High Very High
Pituitary Cancer 16 92.64 High High
Myocardial Infarction 69 90.56 High High
Disease 3 88.92 High High
Pain 1 79.16 Quite High
Cv General 3 Under Development 3 75.68 Quite High
Reprotox - General 1 2 75.00 Quite High
Diabetic Macular Edema 21 72.56 Quite High
Coronary Artery Disease 9 68.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we have demonstrated that IVTA inhibits the increased expression of Vegf-a and Flk-1 in early diabetic rat retinas.
Negative_regulation (inhibits) of Flk-1 in retinas associated with diabetes mellitus
1) Confidence 0.37 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.75 Pain Relevance 0
The expression of genes Mdr1a, Mrp1, Bcrp, Glut-1 and Occludin, was slightly increased, while that of Flk-1 was decreased in microvessels from morphine-treated rats.
Negative_regulation (decreased) of Flk-1 associated with morphine
2) Confidence 0.28 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18761714 Disease Relevance 0 Pain Relevance 0.62
On the other hand, the expression level of Flk-1 mRNA was decreased significantly in the E2+G6-31 group compared to the E2 group (Fig. 5K).


Negative_regulation (decreased) of Flk-1
3) Confidence 0.24 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.09 Pain Relevance 0
Furthermore, dominant-negative inhibition of Flk-1 has been found to reduce tumor angiogenesis and growth [38] and these findings suggest that Flk-1 plays an important role in the development of tumor angiogenesis and growth [54].
Negative_regulation (inhibition) of Flk-1 associated with cancer
4) Confidence 0.24 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.74 Pain Relevance 0
Studies of taxane combinations with bevacizumab (Avastin), thalidomide (Thalomid), bortezomib (Velcade), antisense Bcl-2 oligonucleotide, mTOR inhibitors, epidermal growth factor receptor inhibitors, and KDR inhibitors are under way.
Negative_regulation (inhibitors) of KDR
5) Confidence 0.12 Published 2005 Journal Oncology (Williston Park, N.Y.) Section Abstract Doc Link 15945343 Disease Relevance 0.36 Pain Relevance 0.08
We observed a significant reduction in the expression of VEGF (1.75-fold) and Flk-1 (7.1-fold) 4 days after the surgical procedure in the DS-operated animals compared with the CS-operated animals (Fig. 4A and B).
Negative_regulation (reduction) of Flk-1
6) Confidence 0.10 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.10 Pain Relevance 0
RESULTS: A synergistic interaction (P = 0.015) between decreased CD34+/KDR+ cell counts and increased plasma ADMA, but not symmetrical dimethyl-L-arginine, was the sole significant multivariate DeltaeGFR predictor irrespective of baseline eGFR.
Negative_regulation (decreased) of KDR in plasma
7) Confidence 0.05 Published 2010 Journal Nephrol. Dial. Transplant. Section Body Doc Link 19729464 Disease Relevance 0.14 Pain Relevance 0

General Comments

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