INT127692

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.26
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CXCL1) signal transduction (CXCL1) extracellular space (CXCL1)
extracellular region (CXCL1) intracellular (CXCL1)
Anatomy Link Frequency
endothelial cell 2
pancreas 2
brain 2
lung 2
CXCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 72 100.00 Very High Very High Very High
ischemia 34 99.56 Very High Very High Very High
anesthesia 7 95.36 Very High Very High Very High
Inflammation 139 93.32 High High
rheumatoid arthritis 49 92.56 High High
cytokine 22 86.72 High High
Inflammatory mediators 4 77.48 Quite High
cINOD 5 59.16 Quite High
Snapping jaw 8 50.00 Quite Low
imagery 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 1 99.64 Very High Very High Very High
Cv Unclassified Under Development 16 99.56 Very High Very High Very High
Colon Cancer 68 99.44 Very High Very High Very High
Polyps 58 99.12 Very High Very High Very High
Colorectal Cancer 32 98.44 Very High Very High Very High
Lung Cancer 2 98.34 Very High Very High Very High
Infection 2 98.00 Very High Very High Very High
Hypoxia 1 97.88 Very High Very High Very High
Cancer 85 97.80 Very High Very High Very High
Cv General 4 Under Development 16 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pre-treatment with candesartan or aliskiren attenuated this increase of CXCL1 expression 24 h post-ischemia.
Positive_regulation (increase) of Gene_expression (expression) of CXCL1 associated with ischemia
1) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993950 Disease Relevance 1.16 Pain Relevance 0.44
In addition, IL-8, CXCL1, CXCL2, CXCL3, and CCL20 had higher levels of expression in the polyps compared to normal, which is in keeping with the current study.
Positive_regulation (levels) of Gene_expression (had) of CXCL1 associated with polyps
2) Confidence 0.43 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017541 Disease Relevance 1.30 Pain Relevance 0.26
Gene expression of CXCL1, interleukin-6 and TNF-alpha was upregulated in ischemic brain areas of dTGR (Fig. 5).
Positive_regulation (upregulated) of Gene_expression (expression) of CXCL1 in brain
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993950 Disease Relevance 0.37 Pain Relevance 0.04
Wang et al. (2006) [18] reported that expression of CXCL1 induced by PGE2 was linked to angiogenesis in colorectal cancer in vitro and in vivo and thus provided a link between COX-2 up-regulation and chemokine induced tumour associated endothelial cell migration.
Positive_regulation (induced) of Gene_expression (expression) of CXCL1 in endothelial cell associated with colorectal cancer, chemokine and cancer
4) Confidence 0.40 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017541 Disease Relevance 1.60 Pain Relevance 0.22
This conclusion is supported, at least in part, by the results of Sukumaran and colleagues [52], who reported the upregulated expression of chemokine genes encoding CXCL1, CXCL2, CXCL3, CXCL8, CCL3, CCL4 and CCL20 after infection of PMN with Anaplasma phagocytophilum.
Positive_regulation (upregulated) of Gene_expression (expression) of CXCL1 associated with chemokine and infection
5) Confidence 0.18 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.59 Pain Relevance 0.50
CXCL6 also has angiogenesis activity and can stimulate cancer cell progression.26,27 Zhu et al reported overexpression of CXCL6 with its receptor, IL8R, in hypoxic small cell lung cancer, which is an autocrine regulation for cell progression.28 Rubie et al observed an overexpression of CXCL1 and CXCL5 in CRC, but the level of CXCL6 was not changed.29 Our observations showed that copy number loss and low expression levels were correlated with the invasiveness of CRC.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CXCL1 in lung associated with lung cancer, hypoxia, cancer and colon cancer
6) Confidence 0.18 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 0.68 Pain Relevance 0.16
Increases in gene expression of IL-8, GRO-alpha, MCP-1, and RANTES in response to TNF-alpha treatment were detected.
Positive_regulation (response) of Gene_expression (expression) of GRO-alpha
7) Confidence 0.10 Published 2005 Journal J. Oral Pathol. Med. Section Body Doc Link 15946184 Disease Relevance 0.14 Pain Relevance 0
Increases in gene expression of IL-8, GRO-alpha, MCP-1, and RANTES in response to TNF-alpha treatment were detected.
Positive_regulation (Increases) of Gene_expression (expression) of GRO-alpha
8) Confidence 0.10 Published 2005 Journal J. Oral Pathol. Med. Section Body Doc Link 15946184 Disease Relevance 0.14 Pain Relevance 0
OBJECTIVES: The level of pancreatic stone protein/regenerating protein (PSP/reg), a secretory protein produced in the pancreas, increases dramatically during pancreatic disease.
Positive_regulation (increases) of Gene_expression (level) of secretory protein in pancreas associated with pancreatitis
9) Confidence 0.02 Published 2009 Journal Crit. Care Med. Section Abstract Doc Link 19325491 Disease Relevance 0.27 Pain Relevance 0.10

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