INT127695

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Context Info
Confidence 0.64
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.29
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AIFM1) mitochondrion (AIFM1) oxidoreductase activity (AIFM1)
nucleus (AIFM1) DNA binding (AIFM1) cytoplasm (AIFM1)
Anatomy Link Frequency
HT-29 2
cleavage 2
AIFM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 11 99.98 Very High Very High Very High
aspirin 18 96.80 Very High Very High Very High
cINOD 8 94.52 High High
Inflammation 5 76.24 Quite High
Pain 2 75.56 Quite High
ischemia 3 49.80 Quite Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 35 100.00 Very High Very High Very High
Parkinson's Disease 6 99.16 Very High Very High Very High
Adenocarcinoma 2 98.64 Very High Very High Very High
Alagille Syndrome 4 96.24 Very High Very High Very High
Death 21 95.32 Very High Very High Very High
Injury 4 94.92 High High
INFLAMMATION 8 93.80 High High
Colon Cancer 4 92.20 High High
Stress 24 81.24 Quite High
Ulcers 2 79.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin-induced caspase-9, Bid cleavage, and AIF translocation were blocked by calpeptin, and BAPTA and calpeptin attenuated calpain activation and Bid cleavage.
Positive_regulation (induced) of Localization (translocation) of AIF in cleavage associated with qutenza
1) Confidence 0.64 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.09 Pain Relevance 0.76
We proposed that the responsible mechanism was through mitochondrial failure, increased mitochondrial membrane permeability, and translocation of the intramitochondrial protein apoptosis-inducing factor (AIF).
Positive_regulation (increased) of Localization (translocation) of apoptosis-inducing factor associated with apoptosis
2) Confidence 0.43 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 18612824 Disease Relevance 1.04 Pain Relevance 0.51
We proposed that the responsible mechanism was through mitochondrial failure, increased mitochondrial membrane permeability, and translocation of the intramitochondrial protein apoptosis-inducing factor (AIF).
Positive_regulation (increased) of Localization (translocation) of AIF associated with apoptosis
3) Confidence 0.43 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 18612824 Disease Relevance 1.04 Pain Relevance 0.51
Sulindac activates nuclear translocation of AIF, DFF40 and endonuclease G but not induces oligonucleosomal DNA fragmentation in HT-29 cells.
Neg (not) Positive_regulation (activates) of Localization (translocation) of AIF in HT-29
4) Confidence 0.39 Published 2005 Journal Life Sci. Section Title Doc Link 15946692 Disease Relevance 0.66 Pain Relevance 0.09
In particular, mitochondrial Ca2+ overload can favor cardiolipin peroxidation, thereby affecting mitochondrial permeability transition, inducing AIF and cytochrome C release, and culminating in mitochondrial dysfunction and apoptosis [61], [62].
Positive_regulation (inducing) of Localization (release) of AIF associated with parkinson's disease and apoptosis
5) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.45 Pain Relevance 0

General Comments

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