INT127698

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Context Info
Confidence 0.79
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 13.45
Pain Relevance 4.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AIFM1) mitochondrion (AIFM1) oxidoreductase activity (AIFM1)
nucleus (AIFM1) DNA binding (AIFM1) cytoplasm (AIFM1)
Anatomy Link Frequency
nucleus 4
HT-29 1
colon 1
pores 1
cleavage 1
AIFM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 41 99.76 Very High Very High Very High
dexamethasone 8 96.00 Very High Very High Very High
aspirin 45 94.76 High High
cINOD 21 94.52 High High
Inflammation 56 74.20 Quite High
Pain 5 73.52 Quite High
ischemia 3 49.44 Quite Low
cytokine 29 5.00 Very Low Very Low Very Low
Kinase C 21 5.00 Very Low Very Low Very Low
Hippocampus 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 449 100.00 Very High Very High Very High
Parkinson's Disease 23 99.16 Very High Very High Very High
Colon Cancer 9 98.98 Very High Very High Very High
Adenocarcinoma 5 98.64 Very High Very High Very High
Death 175 97.76 Very High Very High Very High
Hypercalcemia 3 96.60 Very High Very High Very High
Alagille Syndrome 10 96.24 Very High Very High Very High
INFLAMMATION 71 93.80 High High
Injury 26 92.88 High High
Stress 128 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With 40 mM ASA at 4 h, translocation of AIF from the mitochondria to the nucleus occurred, showing activation.
Localization (translocation) of AIF in nucleus
1) Confidence 0.79 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 18612824 Disease Relevance 0.79 Pain Relevance 0.18
Furthermore, capsaicin-induced the mitochondrial apoptotic pathway through calpain-mediated Bid translocation to the mitochondria and nuclear translocation of apoptosis-inducing factor (AIF).
Localization (translocation) of apoptosis-inducing factor associated with qutenza and apoptosis
2) Confidence 0.74 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.12 Pain Relevance 0.77
Furthermore, capsaicin-induced the mitochondrial apoptotic pathway through calpain-mediated Bid translocation to the mitochondria and nuclear translocation of apoptosis-inducing factor (AIF).
Localization (translocation) of AIF associated with qutenza and apoptosis
3) Confidence 0.74 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.12 Pain Relevance 0.77
Capsaicin-induced caspase-9, Bid cleavage, and AIF translocation were blocked by calpeptin, and BAPTA and calpeptin attenuated calpain activation and Bid cleavage.
Localization (translocation) of AIF in cleavage associated with qutenza
4) Confidence 0.74 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.07 Pain Relevance 0.75
The results showed that untreated cells had AIF localized to the mitochondria and cytosol.
Localization (localized) of AIF
5) Confidence 0.69 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 18612824 Disease Relevance 0.83 Pain Relevance 0.18
We proposed that the responsible mechanism was through mitochondrial failure, increased mitochondrial membrane permeability, and translocation of the intramitochondrial protein apoptosis-inducing factor (AIF).
Localization (translocation) of apoptosis-inducing factor associated with apoptosis
6) Confidence 0.69 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 18612824 Disease Relevance 1.03 Pain Relevance 0.50
Caspase inhibition with z-VAD was unable to prevent AIF localization to the nucleus and subsequently unable to prevent cell death.
Localization (localization) of AIF in nucleus associated with death
7) Confidence 0.69 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 18612824 Disease Relevance 0.71 Pain Relevance 0.18
We proposed that the responsible mechanism was through mitochondrial failure, increased mitochondrial membrane permeability, and translocation of the intramitochondrial protein apoptosis-inducing factor (AIF).
Localization (translocation) of AIF associated with apoptosis
8) Confidence 0.69 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 18612824 Disease Relevance 1.03 Pain Relevance 0.50
Sulindac activates nuclear translocation of AIF, DFF40 and endonuclease G but not induces oligonucleosomal DNA fragmentation in HT-29 cells.
Localization (translocation) of AIF in HT-29
9) Confidence 0.62 Published 2005 Journal Life Sci. Section Title Doc Link 15946692 Disease Relevance 0.66 Pain Relevance 0.09
This study was undertaken to dissect the molecular mechanism underlying sulindac-induced apoptosis in human colon cancer cell line HT-29 (mutant p53), focusing on nuclear translocation of AIF, DFF and endonuclease G.
Localization (translocation) of AIF in colon associated with colon cancer and apoptosis
10) Confidence 0.62 Published 2005 Journal Life Sci. Section Abstract Doc Link 15946692 Disease Relevance 0.71 Pain Relevance 0.09
It is worth noting that the apoptosis-inducing factor translocated into the cytosol and nucleus from the mitochondria.
Localization (translocated) of apoptosis-inducing factor in nucleus associated with apoptosis
11) Confidence 0.43 Published 2009 Journal Oncol. Rep. Section Abstract Doc Link 19212624 Disease Relevance 0.58 Pain Relevance 0.55
Enhanced apoptosis is observed which does not involve caspase 3 activation but the translocation of apoptosis inducing factor (AIF) to the nucleus.
Localization (translocation) of apoptosis inducing factor in nucleus associated with apoptosis
12) Confidence 0.13 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.95 Pain Relevance 0.18
In particular, mitochondrial Ca2+ overload can favor cardiolipin peroxidation, thereby affecting mitochondrial permeability transition, inducing AIF and cytochrome C release, and culminating in mitochondrial dysfunction and apoptosis [61], [62].
Localization (release) of AIF associated with parkinson's disease and apoptosis
13) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.45 Pain Relevance 0
ROS-mediated activation of the intrinsic apoptotic pathway involves the release of several mitochondrial proteins, such as cytochrome C, AIF and Smac/DIABLO.
Localization (release) of AIF associated with apoptosis
14) Confidence 0.10 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.62 Pain Relevance 0
Mitochondrial membrane permeability (MMP) determines the release of cytochrome C, Smac/DIABLO, AIF and endonuclease G (Endo G).
Spec (determines) Localization (release) of AIF
15) Confidence 0.10 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.79 Pain Relevance 0
The mitochondria contains proapoptotic proteins such as Apoptosis Inducing Factor (AIF), Smac/DIABLO, and cytochrome C, which are released through these pores, which in turn leads to the formation of the apoptosome and the activation of the caspase cascade [27, 28].
Localization (released) of Apoptosis Inducing Factor in pores associated with apoptosis
16) Confidence 0.09 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.99 Pain Relevance 0

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