INT12770

Context Info Confidence 0.56 First Reported 1991 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 0.34 Pain Relevance 3.02

cytosol (IKBKG) nucleus (IKBKG) cytoplasm (IKBKG) signal transducer activity (IKBKG)

Anatomy Link Frequency hippocampus 4 aorta 2 IKBKG (Homo sapiens)

Pain Link Frequency Relevance Heat Clonidine 21 99.88 tetrodotoxin 2 99.70 Morphine 1 98.94 Versed 3 98.68 ketamine 2 98.46 antagonist 4 98.36 Hippocampus 8 94.72 Pyramidal cell 4 89.88 Potency 1 87.16 Kinase C 8 79.76

Disease Link Frequency Relevance Heat Pathologic Constriction 11 97.04 Stress 13 82.16 Cv Unclassified Under Development 10 50.00 Stroke 2 5.00 Disease 1 5.00 Syndrome 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Clonidine enhanced IP1 accumulation in the aorta in the absence of endothelium, whereas it inhibited NE-induced IP1 accumulation in the aorta.

Negative_regulation (inhibited) of Positive_regulation (accumulation) of IP1 in aorta associated with clonidine

1) Confidence 0.56 Published 1998 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 10100505 Disease Relevance 0 Pain Relevance 0.81

On the other hand, thiamylal augmented inositol monophosphate (IP1) accumulation, whilst ketamine, midazolam and morphine did not have the effect, and fentanyl significantly attenuated IP1 accumulation.

Negative_regulation (attenuated) of Positive_regulation (accumulation) of IP1 associated with versed, ketamine and morphine

2) Confidence 0.54 Published 1997 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 9144836 Disease Relevance 0 Pain Relevance 0.29

Clonidine also attenuated the accumulation of aluminium fluoride-induced IP1.

Negative_regulation (attenuated) of Positive_regulation (induced) of IP1 associated with clonidine

3) Confidence 0.43 Published 2000 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11197082 Disease Relevance 0 Pain Relevance 0.53

Clonidine also attenuated the accumulation of aluminium fluoride-induced IP1.

Negative_regulation (attenuated) of Positive_regulation (accumulation) of IP1 associated with clonidine

4) Confidence 0.43 Published 2000 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11197082 Disease Relevance 0 Pain Relevance 0.53

These compounds blocked insulin stimulation of IP1 accumulation, suggesting that the action of insulin to stimulate PI turnover is secondary to enhancement of endogenous noradrenergic activity within the hippocampus.

Negative_regulation (blocked) of Positive_regulation (accumulation) of IP1 in hippocampus associated with hippocampus

5) Confidence 0.08 Published 1991 Journal Brain Res. Section Abstract Doc Link 1653632 Disease Relevance 0 Pain Relevance 0.38

Addition of tetrodotoxin resulted in a suppression of insulin stimulation of [3H]IP1 release, suggesting that insulin effects may be indirect and mediated via release of an endogenous neuronal transmitter within the hippocampus.

Negative_regulation (suppression) of Positive_regulation (stimulation) of IP1 in hippocampus associated with tetrodotoxin and hippocampus

6) Confidence 0.07 Published 1991 Journal Brain Res. Section Abstract Doc Link 1653632 Disease Relevance 0 Pain Relevance 0.48

Peculiarly, the ratio DIN/IP increased more steeply which seems to prevent a significant increase of IP.

Negative_regulation (prevent) of Positive_regulation (increase) of IP

7) Confidence 0.06 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2874547 Disease Relevance 0.34 Pain Relevance 0

General Comments

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