INT127709

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.55
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hcrt)
Anatomy Link Frequency
neurons 2
Hcrt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GABAergic 4 98.40 Very High Very High Very High
Nucleus accumbens 3 95.12 Very High Very High Very High
Ventral tegmentum 3 92.84 High High
Enkephalin 1 89.80 High High
agonist 1 88.36 High High
opioid receptor 1 88.04 High High
tetrodotoxin 1 83.28 Quite High
Central nervous system 6 80.60 Quite High
Opioid 1 75.00 Quite High
Neuropeptide 5 73.96 Quite High
Disease Link Frequency Relevance Heat
African Trypanosomiasis 13 99.08 Very High Very High Very High
Cognitive Disorder 2 76.16 Quite High
Disease 12 74.56 Quite High
Obesity 1 71.60 Quite High
Infection 29 60.16 Quite High
Trypanosomiasis 1 34.88 Quite Low
INFLAMMATION 14 32.56 Quite Low
Body Weight 8 5.00 Very Low Very Low Very Low
Parasitemia 3 5.00 Very Low Very Low Very Low
Weight Gain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypocretin-1 (1 microM) produced a significant increase in the frequency and amplitude of both GABAergic and glycinergic inhibitory postsynaptic currents and a significant decrease in the frequency of glutamatergic excitatory postsynaptic currents.
Positive_regulation (increase) of Gene_expression (produced) of Hypocretin-1 associated with gabaergic
1) Confidence 0.45 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15947034 Disease Relevance 0 Pain Relevance 0.32
We further show that accumbens DAMGO in the absence of food selectively increases the proportion of orexin neurons expressing c-Fos in parts of the perifornical hypothalamus and that neural projections originating in DAMGO-responsive sites of the nucleus accumbens make close anatomical contacts with hypothalamic orexin neurons.
Positive_regulation (increases) of Gene_expression (expressing) of orexin in neurons associated with nucleus accumbens
2) Confidence 0.35 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17928449 Disease Relevance 0.22 Pain Relevance 0.50
Although SOREMPs are also observed in HAT, our group has demonstrated that they do not depend on a lack of hypocretin availability since the concentration of CSF hypocretin was found to be near normal control values in HAT patients [33].
Neg (not) Positive_regulation (depend) of Gene_expression (availability) of hypocretin associated with african trypanosomiasis
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821905 Disease Relevance 0.33 Pain Relevance 0.03

General Comments

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