INT12771

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 27
Total Number 29
Disease Relevance 5.99
Pain Relevance 7.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IKBKG) nucleus (IKBKG) cytoplasm (IKBKG)
signal transducer activity (IKBKG)
Anatomy Link Frequency
aorta 2
hippocampus 2
plasma 1
caudate nucleus 1
endbulbs 1
IKBKG (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 36 99.80 Very High Very High Very High
Inflammation 25 99.64 Very High Very High Very High
substance P 10 99.58 Very High Very High Very High
tetrodotoxin 10 99.24 Very High Very High Very High
agonist 6 99.00 Very High Very High Very High
Pain 1 99.00 Very High Very High Very High
Morphine 2 98.72 Very High Very High Very High
Versed 3 98.46 Very High Very High Very High
Inflammatory response 4 98.36 Very High Very High Very High
ketamine 7 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 27 99.64 Very High Very High Very High
Pathologic Constriction 66 99.60 Very High Very High Very High
Pain 1 99.00 Very High Very High Very High
Infection 91 98.96 Very High Very High Very High
Frailty 4 98.40 Very High Very High Very High
Neurogenic Inflammation 1 98.04 Very High Very High Very High
Blister 1 96.72 Very High Very High Very High
Stress 86 96.36 Very High Very High Very High
Increased Venous Pressure Under Development 1 95.80 Very High Very High Very High
Hypertrophy 6 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The concentration-effect relationship of IP1 accumulation was similar to that of carbachol-induced contraction; r = 0.797, P < 0.001.
Positive_regulation (accumulation) of IP1
1) Confidence 0.69 Published 2000 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11197082 Disease Relevance 0 Pain Relevance 0.52
Clonidine also attenuated the accumulation of aluminium fluoride-induced IP1.
Positive_regulation (induced) of IP1 associated with clonidine
2) Confidence 0.69 Published 2000 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11197082 Disease Relevance 0 Pain Relevance 0.52
Clonidine also attenuated the accumulation of aluminium fluoride-induced IP1.
Positive_regulation (accumulation) of IP1 associated with clonidine
3) Confidence 0.69 Published 2000 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11197082 Disease Relevance 0 Pain Relevance 0.53
The maximal amount of [3H]IP1 accumulated in the presence of 10 mM LiCl was about 50-fold above the basal level.
Positive_regulation (accumulated) of IP1
4) Confidence 0.67 Published 1989 Journal Brain Res. Section Abstract Doc Link 2557126 Disease Relevance 0.16 Pain Relevance 0.10
Clonidine enhanced IP1 accumulation in the aorta in the absence of endothelium, whereas it inhibited NE-induced IP1 accumulation in the aorta.
Positive_regulation (accumulation) of IP1 in aorta associated with clonidine
5) Confidence 0.67 Published 1998 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 10100505 Disease Relevance 0 Pain Relevance 0.81
On the other hand, thiamylal augmented inositol monophosphate (IP1) accumulation, whilst ketamine, midazolam and morphine did not have the effect, and fentanyl significantly attenuated IP1 accumulation.
Positive_regulation (accumulation) of IP1 associated with versed, ketamine and morphine
6) Confidence 0.64 Published 1997 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 9144836 Disease Relevance 0 Pain Relevance 0.29
Clonidine enhanced IP1 accumulation in the aorta in the absence of endothelium, whereas it inhibited NE-induced IP1 accumulation in the aorta.
Positive_regulation (accumulation) of IP1 in aorta associated with clonidine
7) Confidence 0.58 Published 1998 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 10100505 Disease Relevance 0 Pain Relevance 0.83
Finally, it is important to note that IKBKG/NEMO was induced in the WTSTS cells compared to WT cells (Additional file 2, Table S2).
Positive_regulation (induced) of IKBKG
8) Confidence 0.45 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.31 Pain Relevance 0
SP was found to induce IP1 accumulation in a concentration dependent manner.
Positive_regulation (accumulation) of IP1 associated with substance p
9) Confidence 0.44 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2469033 Disease Relevance 0.27 Pain Relevance 0.57
Tityustoxin specifically stimulated the turnover of glycerophosphoinositol (GP1), inositol 1-monophosphate (IP1), inositol 1,4-biphosphate (IP2) and inositol 1,4,5-triphosphate (IP3).
Positive_regulation (stimulated) of IP1
10) Confidence 0.37 Published 1990 Journal Neuropharmacology Section Abstract Doc Link 2293061 Disease Relevance 0 Pain Relevance 0.09
or NEMO), was upregulated.
Positive_regulation (upregulated) of NEMO
11) Confidence 0.31 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.57 Pain Relevance 0.11
Prostacyclin activation of prostanoid IP receptors may result in pain sensation, inflammatory responses, inhibition of platelet aggregation, and vasodilation in vascular tissue.
Positive_regulation (activation) of IP in platelet associated with pain, inflammatory response and increased venous pressure under development
12) Confidence 0.28 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15194446 Disease Relevance 0.29 Pain Relevance 0.18
The muscarinic agonists, carbachol and oxotremorine, also stimulated [3H]IP1 accumulation.
Positive_regulation (accumulation) of IP1 associated with agonist
13) Confidence 0.20 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2854073 Disease Relevance 0 Pain Relevance 0.21
Infection is shown by inducing inflammation in the system by increasing phospho-IkB kinase concentration (IKK) levels; which lead to increased NF-?
Positive_regulation (increasing) of phospho-IkB kinase associated with inflammation and infection
14) Confidence 0.14 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2811723 Disease Relevance 0.26 Pain Relevance 0.10
The physostigmine dose-response curve for the stimulation of [3H]IP1 accumulation was similar to its dose-response curve to inhibit acetylcholinesterase activity in the neostriatum.
Positive_regulation (accumulation) of IP1
15) Confidence 0.13 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2854073 Disease Relevance 0 Pain Relevance 0.22
Tetrodotoxin partially inhibited the physostigmine-induced [3H]IP1 accumulation but had no effect on the carbachol-induced accumulation. 4-Aminopyridine stimulated the basal [3H]IP1 accumulation and potentiated the physostigmine-induced accumulation.
Positive_regulation (accumulation) of IP1 associated with tetrodotoxin
16) Confidence 0.13 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2854073 Disease Relevance 0 Pain Relevance 0.23
These compounds blocked insulin stimulation of IP1 accumulation, suggesting that the action of insulin to stimulate PI turnover is secondary to enhancement of endogenous noradrenergic activity within the hippocampus.
Positive_regulation (accumulation) of IP1 in hippocampus associated with hippocampus
17) Confidence 0.13 Published 1991 Journal Brain Res. Section Abstract Doc Link 1653632 Disease Relevance 0 Pain Relevance 0.38
The upregulation of NEMO is most likely the result of continued NF-?
Positive_regulation (upregulation) of NEMO
18) Confidence 0.12 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.23 Pain Relevance 0
It is noteworthy that IP never increased significantly and to this is associated a steeply increase of its catabolism in peroxisomes as demonstrated by the ratio DIN/IP, suggesting an efficient physiological response to IP formation.
Neg (never) Positive_regulation (increased) of IP
19) Confidence 0.09 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2874547 Disease Relevance 0.66 Pain Relevance 0.10
Finally, it is important to note that IKBKG/NEMO was induced in the WTSTS cells compared to WT cells (Additional file 2, Table S2).
Positive_regulation (induced) of NEMO
20) Confidence 0.09 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.30 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox