INT127714

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.24
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GEM) plasma membrane (GEM) GTPase activity (GEM)
Anatomy Link Frequency
motor neurons 1
GEM (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 9 99.82 Very High Very High Very High
potassium channel 6 97.60 Very High Very High Very High
Inflammation 15 91.84 High High
Spinal cord 10 91.52 High High
tetrodotoxin 1 88.60 High High
rheumatoid arthritis 31 76.84 Quite High
adenocard 1 75.00 Quite High
Angina 1 72.36 Quite High
Pain 2 64.36 Quite High
dorsal root ganglion 4 55.68 Quite High
Disease Link Frequency Relevance Heat
Toxicity 1 96.76 Very High Very High Very High
Motor Neuron Diseases 19 94.96 High High
INFLAMMATION 15 91.84 High High
Metastasis 1 91.56 High High
Meningeal Carcinomatosis 2 82.84 Quite High
Rheumatoid Arthritis 32 76.84 Quite High
Disease 84 76.00 Quite High
Pancreatic Cancer 2 75.00 Quite High
Cv General 3 Under Development 1 72.36 Quite High
Emergencies 1 71.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The dose of GEM was reduced during the radiotherapy, and the total dose was 113.2 g.
Negative_regulation (reduced) of GEM
1) Confidence 0.37 Published 2008 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 19098414 Disease Relevance 0.59 Pain Relevance 0.06
changes in KIR expression, (ii) patients with a decrease in KIR
Negative_regulation (decrease) of KIR
2) Confidence 0.23 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804296 Disease Relevance 0.29 Pain Relevance 0.12
Tertiapin, a short peptide from honey bee venom, has been reported to specifically block the inwardly rectifying K(+) (Kir) channels, including G protein-coupled inwardly rectifying potassium channel (GIRK) 1+GIRK4 heteromultimers and ROMK1 homomultimers.
Negative_regulation (block) of Kir associated with potassium channel
3) Confidence 0.03 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15947038 Disease Relevance 0.11 Pain Relevance 0.15
This observation, associated with findings that impaired K+ buffering through loss of Kir.4 channel [44], could give an explanation to the understanding of the paracrine toxicity of motor neurons that is typical of ALS.
Negative_regulation (loss) of Kir in motor neurons associated with toxicity and motor neuron diseases
4) Confidence 0.02 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.03 Pain Relevance 0.13
Cholesterol depletion with methyl-beta-cyclodextrin significantly reduced, whereas overexpression of caveolin-1 largely enhanced, PKC-induced inhibition of Kir6.1/SUR2B currents.
Negative_regulation (inhibition) of Kir6 associated with kinase c
5) Confidence 0.02 Published 2008 Journal Hypertension Section Abstract Doc Link 18663158 Disease Relevance 0.22 Pain Relevance 0.46
Pharmacologic blockade of Kv and Nav, but not Kir, suppressed RGM-1 cell proliferation.
Negative_regulation (blockade) of Kir
6) Confidence 0.01 Published 2006 Journal J. Cell. Physiol. Section Abstract Doc Link 16331678 Disease Relevance 0 Pain Relevance 0.09

General Comments

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