INT127717

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.09
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (TRPM8)
Anatomy Link Frequency
epithelial cells 2
nerve 1
MCF-7 1
TRPM8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 18 99.84 Very High Very High Very High
Thermal hyperalgesia 4 99.04 Very High Very High Very High
c fibre 12 98.92 Very High Very High Very High
Dorsal horn 10 98.80 Very High Very High Very High
Inflammation 8 98.62 Very High Very High Very High
dorsal root ganglion 45 97.96 Very High Very High Very High
Spinal cord 14 93.76 High High
Action potential 3 92.00 High High
bradykinin 3 84.80 Quite High
unmyelinated 6 81.16 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 6 99.04 Very High Very High Very High
INFLAMMATION 10 98.62 Very High Very High Very High
Ganglion Cysts 47 97.96 Very High Very High Very High
Reprotox - General 1 17 83.68 Quite High
Nociception 4 78.48 Quite High
Bladder Disease 34 77.28 Quite High
Injury 20 73.72 Quite High
Peripheral Neuropathy 1 64.00 Quite High
Pain 33 59.20 Quite High
Cancer 16 57.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Single-cell reverse transcriptase PCR and immunohistochemical experiments also showed that the trpm8 gene was mainly expressed in the apical secretory epithelial cells of the human prostate and trpm8 down-regulation occurred during the loss of the apical differentiated phenotype of the primary cultured human prostate epithelial cells.
Negative_regulation (down) of trpm8 in epithelial cells
1) Confidence 0.59 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947109 Disease Relevance 0.23 Pain Relevance 0.07
Yet, silencing of endogenous TRPM8 mRNA by either antisense or siRNA strategies suppresses both I(cold/menthol) and TRPM8 protein in LNCaP cells.
Negative_regulation (suppresses) of TRPM8 protein
2) Confidence 0.59 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16174775 Disease Relevance 0.16 Pain Relevance 0.15
Here, we show that TRPM8 is functionally downregulated by activation of protein kinase C (PKC) resulting in inhibition of membrane currents and increases in intracellular Ca2+ compared with upregulation of TRPV1 in cloned and native receptors.
Negative_regulation (downregulated) of TRPM8 associated with kinase c
3) Confidence 0.47 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16339027 Disease Relevance 0.35 Pain Relevance 0.68
These findings suggest that inflammatory thermal hyperalgesia mediated by TRPV1 may be further aggravated by downregulation of TRPM8, because the latter could mediate the much needed cool/soothing sensation.
Negative_regulation (downregulation) of TRPM8 associated with inflammation and thermal hyperalgesia
4) Confidence 0.47 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16339027 Disease Relevance 0.49 Pain Relevance 0.74
Single-cell reverse transcriptase PCR and immunohistochemical experiments also showed that the trpm8 gene was mainly expressed in the apical secretory epithelial cells of the human prostate and trpm8 down-regulation occurred during the loss of the apical differentiated phenotype of the primary cultured human prostate epithelial cells.
Negative_regulation (regulation) of trpm8 in epithelial cells
5) Confidence 0.43 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947109 Disease Relevance 0.23 Pain Relevance 0.07
Pre-incubation of the TRPM8 antibody with an excess of peptide to TRPM8 completely abolished the urothelial and nerve fibre TRPM8-immunoreactivity (Fig 1e–f).
Negative_regulation (abolished) of TRPM8-immunoreactivity in nerve
6) Confidence 0.43 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.42 Pain Relevance 0.22
Incubation of MCF-7 cells in DCCFCS induced a significant decrease in TRPM8 mRNA level by 76 ± 8.4% of the control for 48 h and 71.1 ± 6.8% of the control for 72 h (p < 0.01, Fig. 3A).
Negative_regulation (decrease) of TRPM8 mRNA in MCF-7
7) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.06 Pain Relevance 0
TRPM8 mRNA has been shown to be localised mainly in A- delta fibres/C-fibres in rat primary afferent neurones [47].
Negative_regulation (localised) of TRPM8 associated with c fibre
8) Confidence 0.34 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.76 Pain Relevance 0.31
Downregulation of transient receptor potential melastatin 8 by protein kinase C-mediated dephosphorylation.
Negative_regulation (Downregulation) of transient receptor potential melastatin 8 associated with kinase c
9) Confidence 0.30 Published 2005 Journal J. Neurosci. Section Title Doc Link 16339027 Disease Relevance 0.40 Pain Relevance 0.68

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox