INT127718

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 2005
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 8
Total Number 19
Disease Relevance 10.43
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (TRPM8)
Anatomy Link Frequency
MCF-7 4
plasma 2
bladder 2
reticulum 2
body 2
TRPM8 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 12 100.00 Very High Very High Very High
member 8 29 94.88 High High
Pain 58 85.44 High High
qutenza 6 78.96 Quite High
c fibre 22 78.52 Quite High
visual analogue scale 20 78.08 Quite High
hyperexcitability 2 78.08 Quite High
interstitial cystitis 2 77.12 Quite High
dorsal root ganglion 2 76.96 Quite High
imagery 60 75.28 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 300 99.88 Very High Very High Very High
Adenocarcinoma 108 99.80 Very High Very High Very High
Bladder Disease 68 99.76 Very High Very High Very High
Reprotox - General 1 93 99.32 Very High Very High Very High
Cancer 202 98.08 Very High Very High Very High
Disease 4 90.20 High High
Lung Cancer 12 88.80 High High
Skin Cancer 12 88.28 High High
Pain 46 85.44 High High
Interstitial Cystitis 2 77.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The androgen-regulated trpm8 expression mechanisms are important in understanding the progression of prostate cancer to androgen-independence.
Regulation (regulated) of Gene_expression (expression) of trpm8 associated with reprotox - general 1
1) Confidence 0.62 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947109 Disease Relevance 0.25 Pain Relevance 0.06
GDS, ISS, and SLC were responsible for the design and production of the TRPM8 antibodies used, CDB and CB helped conceive the study, with interpretation of the data, and writing the manuscript.
Regulation (responsible) of Gene_expression (production) of TRPM8
2) Confidence 0.62 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.54 Pain Relevance 0.44
The regulators of TRPM8 expression in the bladder are not known.
Regulation (regulators) of Gene_expression (expression) of TRPM8 in bladder
3) Confidence 0.62 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 1.01 Pain Relevance 0.65
It is well established that TRPM8 channel expression is regulated by androgens.
Regulation (regulated) of Gene_expression (expression) of TRPM8
4) Confidence 0.62 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.84 Pain Relevance 0.12
The dependence of TRPM8 expression on the presence of ER?
Regulation (dependence) of Gene_expression (expression) of TRPM8 associated with addiction
5) Confidence 0.62 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.17 Pain Relevance 0.05
Indeed, the androgen regulation of TRPM8 expression was reported in prostate cancer and putative androgen receptor response elements were identified in the TRPM8 gene [20-22].
Regulation (regulation) of Gene_expression (expression) of TRPM8 associated with reprotox - general 1
6) Confidence 0.62 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.85 Pain Relevance 0.12
estradiol (E2) is known to be the main physiological steroid in the breast, we studied the effects of adding E2 on TRPM8 expression in MCF-7 cells cultured under steroid-free conditions.
Regulation (effects) of Gene_expression (expression) of TRPM8 in MCF-7
7) Confidence 0.62 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0 Pain Relevance 0
We also demonstrate that TRPM8 expression and the magnitude of SOC current associated with it are androgen-dependent.
Regulation (androgen-dependent) of Gene_expression (expression) of TRPM8
8) Confidence 0.45 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16174775 Disease Relevance 0.14 Pain Relevance 0.13
To test whether TRPM8 channels are functional at endoplasmic reticulum (ER), cells were perfused with 20 ?
Spec (whether) Regulation (functional) of Spec (whether) Gene_expression (channels) of TRPM8 in reticulum
9) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.09 Pain Relevance 0.04
regulation of TRPM8 in a physiological context, we studied the correlation between the over-expression of TRPM8 and ER?
Regulation (correlation) of Gene_expression (over) of TRPM8
10) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.56 Pain Relevance 0.03
BPH or BOO did not significantly affect the expression of TRPM8.
Neg (not) Regulation (affect) of Gene_expression (expression) of TRPM8
11) Confidence 0.43 Published 2008 Journal Urology Section Body Doc Link 18384850 Disease Relevance 0 Pain Relevance 0
Overexpression of TRPM8 was independent of changes in androgen receptor (AR) mRNA levels in tumor tissue.
Neg (independent) Regulation (independent) of Gene_expression (Overexpression) of TRPM8 associated with cancer
12) Confidence 0.43 Published 2010 Journal Int. J. Oncol. Section Abstract Doc Link 20043080 Disease Relevance 0.84 Pain Relevance 0.09
Androgen regulated TRPM8 expression: a potential mRNA marker for metastatic prostate cancer detection in body fluids.
Regulation (regulated) of Gene_expression (expression) of TRPM8 in body associated with reprotox - general 1
13) Confidence 0.43 Published 2010 Journal Int. J. Oncol. Section Title Doc Link 20043080 Disease Relevance 0.78 Pain Relevance 0.08
In this study, we demonstrate that: 1) MCF-7 breast cancer cell line expressed a classical Icilin-sensitive channel, 2) Icilin induced also an increase of intracellular Ca2+ that was mediated by endogenous plasma membrane TRPM8 activation, 3) only 30% of cells under investigation respond to Icilin, 4) expression of TRPM8 is regulated by estrogens, and 5) the over-expression of TRPM8 in breast adenocarcinomas is correlated with ER+ status.
Regulation (regulated) of Gene_expression (expression) of TRPM8 in plasma associated with adenocarcinoma and breast cancer
14) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.76 Pain Relevance 0
We also determined whether TRPM8 mRNA expression was regulated by estrogens.
Spec (whether) Regulation (regulated) of Spec (whether) Gene_expression (expression) of TRPM8 mRNA
15) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.78 Pain Relevance 0.06
Furthermore, in ER+ MCF-7 cell line, TRPM8 expression is regulated by estrogens.
Regulation (regulated) of Gene_expression (expression) of TRPM8 in MCF-7
16) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 1.13 Pain Relevance 0
Taken together, these results suggest a hormonal-dependent regulation of TRPM8 expression in breast cancer.
Regulation (regulation) of Gene_expression (expression) of TRPM8 associated with breast cancer
17) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.85 Pain Relevance 0
However, in breast cancer, the regulation of TRPM8 gene expression by putative estrogen response elements needs further investigations.


Spec (investigations) Regulation (regulation) of Gene_expression (expression) of TRPM8 gene associated with breast cancer
18) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.48 Pain Relevance 0.03
Estrogen regulation of TRPM8 expression in breast cancer cells

Background

Regulation (regulation) of Gene_expression (expression) of TRPM8 associated with breast cancer
19) Confidence 0.27 Published 2010 Journal BMC Cancer Section Title Doc Link PMC2887400 Disease Relevance 0.35 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox