INT12772

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Context Info
Confidence 0.69
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.84
Pain Relevance 4.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IKBKG) nucleus (IKBKG) cytoplasm (IKBKG)
signal transducer activity (IKBKG)
Anatomy Link Frequency
aorta 4
hippocampus 2
IKBKG (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 24 99.98 Very High Very High Very High
substance P 10 99.72 Very High Very High Very High
agonist 2 99.30 Very High Very High Very High
Inflammation 3 98.32 Very High Very High Very High
antagonist 7 97.72 Very High Very High Very High
Pyramidal cell 4 97.64 Very High Very High Very High
tetrodotoxin 6 97.18 Very High Very High Very High
Hippocampus 8 94.36 High High
Kinase C 8 94.24 High High
Potency 2 90.40 High High
Disease Link Frequency Relevance Heat
Stress 13 99.44 Very High Very High Very High
Neurogenic Inflammation 1 98.32 Very High Very High Very High
Pathologic Constriction 11 98.04 Very High Very High Very High
Blister 1 97.00 Very High Very High Very High
Cv Unclassified Under Development 10 88.08 High High
INFLAMMATION 1 75.00 Quite High
Stroke 2 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clonidine also attenuated the accumulation of aluminium fluoride-induced IP1.
Positive_regulation (accumulation) of Positive_regulation (induced) of IP1 associated with clonidine
1) Confidence 0.69 Published 2000 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11197082 Disease Relevance 0 Pain Relevance 0.53
Clonidine enhanced IP1 accumulation in the aorta in the absence of endothelium, whereas it inhibited NE-induced IP1 accumulation in the aorta.
Positive_regulation (induced) of Positive_regulation (accumulation) of IP1 in aorta associated with clonidine
2) Confidence 0.67 Published 1998 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 10100505 Disease Relevance 0 Pain Relevance 0.81
Clonidine enhanced IP1 accumulation in the aorta in the absence of endothelium, whereas it inhibited NE-induced IP1 accumulation in the aorta.
Positive_regulation (enhanced) of Positive_regulation (accumulation) of IP1 in aorta associated with clonidine
3) Confidence 0.58 Published 1998 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 10100505 Disease Relevance 0 Pain Relevance 0.83
SP was found to induce IP1 accumulation in a concentration dependent manner.
Positive_regulation (induce) of Positive_regulation (accumulation) of IP1 associated with substance p
4) Confidence 0.44 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2469033 Disease Relevance 0.27 Pain Relevance 0.57
The muscarinic agonists, carbachol and oxotremorine, also stimulated [3H]IP1 accumulation.
Positive_regulation (stimulated) of Positive_regulation (accumulation) of IP1 associated with agonist
5) Confidence 0.14 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2854073 Disease Relevance 0 Pain Relevance 0.21
Tetrodotoxin partially inhibited the physostigmine-induced [3H]IP1 accumulation but had no effect on the carbachol-induced accumulation. 4-Aminopyridine stimulated the basal [3H]IP1 accumulation and potentiated the physostigmine-induced accumulation.
Positive_regulation (stimulated) of Positive_regulation (accumulation) of IP1 associated with tetrodotoxin
6) Confidence 0.13 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2854073 Disease Relevance 0 Pain Relevance 0.23
These compounds blocked insulin stimulation of IP1 accumulation, suggesting that the action of insulin to stimulate PI turnover is secondary to enhancement of endogenous noradrenergic activity within the hippocampus.
Positive_regulation (stimulation) of Positive_regulation (accumulation) of IP1 in hippocampus associated with hippocampus
7) Confidence 0.13 Published 1991 Journal Brain Res. Section Abstract Doc Link 1653632 Disease Relevance 0 Pain Relevance 0.38
Interestingly the concomitant increase of CD16:2/CLA and DIN/IP ratios are suggestive of an increased peroxisomal beta oxidation as a physiological response to oxidative stress resulting in a decrease of PUFAHP and IP 2 hours after reperfusion.
Positive_regulation (response) of Positive_regulation (increase) of IP associated with stress
8) Confidence 0.08 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2874547 Disease Relevance 0.57 Pain Relevance 0.12
Concentrations of 1, 10 and 100 nM insulin significantly stimulated the accumulation of [3H]inositol phosphate ([3H]IP1) and [3H]IP2 in hippocampal slices labelled with [3H]myoinositol.
Positive_regulation (stimulated) of Positive_regulation (accumulation) of IP1
9) Confidence 0.07 Published 1991 Journal Brain Res. Section Abstract Doc Link 1653632 Disease Relevance 0 Pain Relevance 0.44

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