INT127724

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Context Info
Confidence 0.73
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 9.35
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CSF1) cell proliferation (CSF1) extracellular space (CSF1)
extracellular region (CSF1) plasma membrane (CSF1)
Anatomy Link Frequency
macrophage 4
osteoclasts 4
chondrocytes 1
granulocyte 1
osteoblasts 1
CSF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 60 100.00 Very High Very High Very High
rheumatoid arthritis 80 92.84 High High
Inflammation 59 90.40 High High
Arthritis 12 89.48 High High
withdrawal 2 69.76 Quite High
Inflammatory response 8 63.72 Quite High
Pain 19 61.04 Quite High
analgesia 4 60.72 Quite High
Spinal cord 2 59.04 Quite High
antagonist 36 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 289 99.86 Very High Very High Very High
Apoptosis 19 99.70 Very High Very High Very High
Hypercalcemia 76 99.40 Very High Very High Very High
Shock 2 99.16 Very High Very High Very High
Metastasis 193 96.92 Very High Very High Very High
Osteoporosis 174 95.20 Very High Very High Very High
Rheumatoid Arthritis 88 92.84 High High
INFLAMMATION 67 90.40 High High
Advanced Or Metastatic Breast Cancer 5 89.84 High High
Arthritis 10 89.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1-induced anti-apoptotic factor 1) and granulocyte/macrophage-colony-stimulating factor (GM-CSF) (e.g. cold shock protein A), and human cartilage protein gp-39 (a major secretory product of articular chondrocytes and synovial cells).
Localization (granulocyte) of macrophage-colony-stimulating factor in granulocyte associated with shock and apoptosis
1) Confidence 0.73 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400410 Disease Relevance 0.90 Pain Relevance 0.27
M-CSF and OPG are produced and released by activated osteoblasts, chondrocytes, and fibroblasts [2, 4–6].
Localization (released) of M-CSF in osteoblasts
2) Confidence 0.45 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.19 Pain Relevance 0.08
Estradiol appears to decrease the responsiveness of osteoclasts to factors such as receptor activator of nuclear factor kappa B ligand (RANKL) and macrophage-colony stimulating factor (M-CSF), released in the bone microenvironment by osteogenic cells and by marrow stroma (Hughes et al 1996; Taranta et al 2002).
Localization (released) of macrophage-colony stimulating factor in osteoclasts
3) Confidence 0.34 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684086 Disease Relevance 0.65 Pain Relevance 0.12
Estradiol appears to decrease the responsiveness of osteoclasts to factors such as receptor activator of nuclear factor kappa B ligand (RANKL) and macrophage-colony stimulating factor (M-CSF), released in the bone microenvironment by osteogenic cells and by marrow stroma (Hughes et al 1996; Taranta et al 2002).
Localization (released) of M-CSF in osteoclasts
4) Confidence 0.29 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684086 Disease Relevance 0.65 Pain Relevance 0.12
1-induced anti-apoptotic factor 1) and granulocyte/macrophage-colony-stimulating factor (GM-CSF) (e.g. cold shock protein A), and human cartilage protein gp-39 (a major secretory product of articular chondrocytes and synovial cells).
Localization (granulocyte) of macrophage-colony-stimulating factor in macrophage associated with shock and apoptosis
5) Confidence 0.25 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400410 Disease Relevance 0.90 Pain Relevance 0.27
RANK-RANKL interaction in the presence of macrophage colony-stimulating factor activates multiple intracellular signaling cascades (nuclear factor-?
Localization (presence) of macrophage colony-stimulating factor in macrophage
6) Confidence 0.22 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 0.69 Pain Relevance 0
Treatment of HDS cells with gefitinib produced a significant reduction in the levels of secreted macrophage colony-stimulating factor (M-CSF) and cell-associated receptor activator of NF-kappaB ligand (RANKL) in both cell lines, as assessed by using specific ELISA and Western blotting techniques.
Localization (secreted) of M-CSF in macrophage
7) Confidence 0.18 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947117 Disease Relevance 0.27 Pain Relevance 0.06
M-CSF and OPG are produced and released by activated osteoblasts, chondrocytes, and fibroblasts [2, 4–6].
Localization (released) of M-CSF in chondrocytes
8) Confidence 0.15 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.19 Pain Relevance 0.08
M-CSF and OPG are produced and released by activated osteoblasts, chondrocytes, and fibroblasts [2, 4–6].
Localization (released) of M-CSF in fibroblasts
9) Confidence 0.15 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.19 Pain Relevance 0.08
Cancer cells release paradigmatic “osteolytic” cytokines, such as parathyroid hormone-related protein (PTHrP), receptor activator of NF-B ligand (RANKL), interleukin-8 (IL-8) and colony stimulating factor-1 (CSF-1), directly or indirectly responsible for the increase in osteoclast recruitment, activity and survival.
Localization (release) of colony stimulating factor-1 in osteoclast associated with cancer and cytokine
10) Confidence 0.14 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 1.81 Pain Relevance 0.20
Cancer cells release paradigmatic “osteolytic” cytokines, such as parathyroid hormone-related protein (PTHrP), receptor activator of NF-B ligand (RANKL), interleukin-8 (IL-8) and colony stimulating factor-1 (CSF-1), directly or indirectly responsible for the increase in osteoclast recruitment, activity and survival.
Localization (release) of CSF-1 in osteoclast associated with cancer and cytokine
11) Confidence 0.14 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 1.81 Pain Relevance 0.20
It is possible that the soluble RANKL is released from the tumor derived cells and the soluble factor interacts with RANK expressed in monocytes resulting in osteoclast-like cell formation in cooperation with macrophage colony stimulating factor secreted from the cells [17].
Localization (secreted) of colony stimulating factor in macrophage associated with cancer
12) Confidence 0.01 Published 2005 Journal BMC Ear Nose Throat Disord Section Body Doc Link PMC1253509 Disease Relevance 0.94 Pain Relevance 0.04
and in the same assay testing for VEGF, M-CSF, TNF-?
Localization (testing) of M-CSF
13) Confidence 0.01 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC400208 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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