INT127725

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.69
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
Anatomy Link Frequency
superior 2
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 98.76 Very High Very High Very High
cINOD 56 98.28 Very High Very High Very High
metalloproteinase 2 97.68 Very High Very High Very High
Inflammation 10 75.00 Quite High
Inflammatory response 2 72.88 Quite High
Pain 3 69.72 Quite High
antagonist 2 58.32 Quite High
aspirin 4 53.00 Quite High
qutenza 4 25.00 Low Low
Immobilon 4 15.44 Low Low
Disease Link Frequency Relevance Heat
Cancer 43 99.22 Very High Very High Very High
Disease 47 98.00 Very High Very High Very High
INFLAMMATION 10 97.56 Very High Very High Very High
Colon Cancer 50 94.60 High High
Apoptosis 73 93.04 High High
Death 23 92.44 High High
Advanced Or Metastatic Breast Cancer 28 88.44 High High
Breast Cancer 18 76.36 Quite High
Metastasis 18 75.00 Quite High
Dermatitis 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant reduction in the basal levels of activation of the EGFR and of Akt was observed in HDS cells following treatment with gefitinib.
Negative_regulation (reduction) of Positive_regulation (activation) of EGFR
1) Confidence 0.57 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947117 Disease Relevance 0.29 Pain Relevance 0.07
Sulindac metabolites inhibit epidermal growth factor receptor activation and expression

Background

Negative_regulation (inhibit) of Positive_regulation (activation) of epidermal growth factor receptor
2) Confidence 0.42 Published 2005 Journal J Carcinog Section Title Doc Link PMC1208922 Disease Relevance 0.76 Pain Relevance 0.37
Together these results identify a new target for the actions of sulindac and suggest that inhibition of EGFR activation may be a major biochemical mechanism for both the downregulation of ERK1/2 signaling and the chemopreventive activity of NSAIDs.


Negative_regulation (inhibition) of Positive_regulation (activation) of EGFR associated with cinod
3) Confidence 0.42 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.27 Pain Relevance 0.34
In addition, in HR-positive HER2-negative tumors, the early use of ErbB inhibitors may prevent or limit the upregulation of ErbB pathways that often occurs in the progression of disease.28 To this ends, several targeted agents are being investigated in combination with endocrine therapy.29–31 Trastuzumab plus anastrazole has shown improved PFS over endocrine blockade alone in women with HR-positive HER-2 positive MBC, and gefitinib plus anastrazole was superior to anastrazole alone in HR-positive MBC patients.29,30
Spec (may) Negative_regulation (prevent) of Positive_regulation (upregulation) of ErbB in superior associated with cancer, advanced or metastatic breast cancer and disease
4) Confidence 0.37 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0.79 Pain Relevance 0
In addition, capsiate inhibited UVB-induced epidermal growth factor receptor (EGFR) activation, which reduces the levels of proinflammatory cytokines and angiogenic factors.
Negative_regulation (reduces) of Positive_regulation (induced) of epidermal growth factor receptor associated with cytokine
5) Confidence 0.34 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20123015 Disease Relevance 0.29 Pain Relevance 0.26
In addition, capsiate inhibited UVB-induced epidermal growth factor receptor (EGFR) activation, which reduces the levels of proinflammatory cytokines and angiogenic factors.
Negative_regulation (reduces) of Positive_regulation (induced) of EGFR associated with cytokine
6) Confidence 0.34 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20123015 Disease Relevance 0.29 Pain Relevance 0.26

General Comments

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