INT127738

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.10
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc) nucleus (Crygb) cytoplasm (Crygb)
Crygb (Mus musculus)
Pnoc (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 13 100.00 Very High Very High Very High
opiate 2 100.00 Very High Very High Very High
Neuropeptide 1 98.64 Very High Very High Very High
antagonist 3 98.48 Very High Very High Very High
Pain 2 95.12 Very High Very High Very High
tolerance 1 93.76 High High
Potency 1 93.04 High High
addiction 1 92.40 High High
imagery 1 55.44 Quite High
Disease Link Frequency Relevance Heat
Pain 1 95.12 Very High Very High Very High
Targeted Disruption 1 47.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nociceptin is an endogenous anti-opiate heptadecapeptide primarily interacting with the nociceptin (NOP) receptor.
NOP Binding (interacting) of Nociceptin associated with orphanin and opiate
1) Confidence 0.49 Published 2005 Journal Peptides Section Abstract Doc Link 15949634 Disease Relevance 0.10 Pain Relevance 0.67
[Nphe1, Arg14, Lys15] N/OFQ-NH2 (UFP-101) is a novel NOP ligand that was designed by combining, in the same molecule, the [Nphe1] chemical modification which eliminates efficacy and the [Arg14, Lys15] substitution which increases ligand potency and duration of action in vivo.
NOP Binding (ligand) of N/OFQ associated with potency
2) Confidence 0.16 Published 2005 Journal CNS Drug Rev Section Abstract Doc Link 16007234 Disease Relevance 0 Pain Relevance 0.32

General Comments

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