INT127740

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.65
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
microglia 2
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 6 100.00 Very High Very High Very High
Inflammation 5 100.00 Very High Very High Very High
tetrodotoxin 7 98.08 Very High Very High Very High
Inflammatory mediators 2 93.32 High High
anesthesia 1 87.28 High High
sodium channel 8 84.76 Quite High
Nav1.9 1 84.12 Quite High
nav1.8 1 83.64 Quite High
Nav1.7 1 83.32 Quite High
nav1.3 1 83.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 100.00 Very High Very High Very High
Sepsis 2 92.00 High High
Hepatotoxicity 1 72.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it remains unknown whether NE affects the release of other inflammatory cytokines such as IL-1beta and IL-10 and, if so, whether alpha(2)-AR is also involved in such a process.
Spec (whether) Regulation (affects) of Localization (release) of IL-10 associated with inflammation and cytokine
1) Confidence 0.60 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15949713 Disease Relevance 0.25 Pain Relevance 0.23
AIM: We hypothesized that ketoprofen would affect release of IL-6 and IL-10 and modulate the immune response.
Regulation (affect) of Localization (release) of IL-10
2) Confidence 0.30 Published 2007 Journal Akush Ginekol (Sofiia) Section Body Doc Link 17469457 Disease Relevance 0 Pain Relevance 0
APAP by itself did not alter release of TNF-alpha, PGE(2), IL-10, Gro/KC or IFN-gamma; however, in the presence of LPS, APAP enhanced LPS-induced TNF-alpha and Gro/KC release.
Neg (not) Regulation (alter) of Localization (release) of IL-10
3) Confidence 0.26 Published 2006 Journal Toxicol In Vitro Section Abstract Doc Link 16782301 Disease Relevance 0.39 Pain Relevance 0.27
Phenytoin attenuated by approximately 50% the release of IL-1 alpha, IL-1 beta, and TNF-alpha from LPS-stimulated microglia, but had minimal effects on the release of IL-2, IL-4, IL-6, IL-10, MCP-1, and TGF-alpha.
Regulation (effects) of Localization (release) of IL-10 in microglia
4) Confidence 0.05 Published 2009 Journal Glia Section Abstract Doc Link 19115387 Disease Relevance 0 Pain Relevance 1.68

General Comments

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