INT127756

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.69
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Map2k1) cytoplasm (Map2k1) cytosol (Map2k1)
cell proliferation (Map2k1) mitosis (Map2k1) cell motility (Map2k1)
Anatomy Link Frequency
colon 2
Map2k1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 10 95.44 Very High Very High Very High
Spinal cord 2 93.92 High High
Hippocampus 2 92.80 High High
metalloproteinase 29 91.68 High High
substance P 6 88.04 High High
spinal dorsal horn 1 84.48 Quite High
nociceptor 5 78.88 Quite High
Inflammation 9 76.08 Quite High
intrathecal 1 75.96 Quite High
Pain 7 75.00 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 184 99.58 Very High Very High Very High
Cancer 262 99.04 Very High Very High Very High
Nociception 4 97.62 Very High Very High Very High
Syndrome 11 96.80 Very High Very High Very High
Carcinoma 17 96.76 Very High Very High Very High
Death 25 96.24 Very High Very High Very High
Skin Cancer 9 96.16 Very High Very High Very High
Hyperalgesia 10 95.44 Very High Very High Very High
Leukemia 4 94.64 High High
Solid Tumor 4 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The nociceptive behavior induced by Sub P administered either i.t. or intracerebroventricularly (i.c.v.) was attenuated by PD98059 (a MEK 1/2 inhibitor) in a dose-dependent manner.
Negative_regulation (inhibitor) of MEK 1 associated with nociception
1) Confidence 0.41 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15950773 Disease Relevance 0.32 Pain Relevance 0.64
Importantly, we show that silencing of MEK2 expression completely suppresses the proliferation of human colon carcinoma cell lines, whereas inactivation of MEK1 has a much weaker effect.


Negative_regulation (inactivation) of MEK1 in colon associated with colon cancer
2) Confidence 0.30 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2596176 Disease Relevance 0.53 Pain Relevance 0.05
Notably, administration of an orally-available inhibitor of MEK1/2 elicited marked anti-tumor efficacy in mouse xenograft models of colon cancer and metastatic melanoma [19,20].
Negative_regulation (inhibitor) of MEK1 in colon associated with cancer, colon cancer and skin cancer
3) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 1.00 Pain Relevance 0
Colorectal cancers often display activation of the ERK1/2 MAP kinase pathway and therefore represent potential targets for MEK1/2 inhibitors [26].
Negative_regulation (inhibitors) of MEK1 associated with colon cancer
4) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.67 Pain Relevance 0
Collectively, these findings have provided strong rationale for the development of small-molecule inhibitors of MEK1/2 for chemotherapeutic intervention in cancer.
Negative_regulation (inhibitors) of MEK1 associated with cancer
5) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.88 Pain Relevance 0
Using anti-phospho-specific Bad (Ser122) and Bad (Ser136) antibodies, we observed that blocking MEK1/2 activity did not alter the levels of Bad phosphorylation at Serine 112 and Serine 136 (data not shown).
Negative_regulation (blocking) of MEK1
6) Confidence 0.26 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.78 Pain Relevance 0
In vivo, inhibition of MEK1 or PKC?
Negative_regulation (inhibition) of MEK1
7) Confidence 0.26 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20861385 Disease Relevance 0.92 Pain Relevance 1.36
The MEK1/2 inhibitor CI-1040 (PD184352) was purchased from US Biologicals (#P3120-55), diluted in DMSO at a concentration of 100 ┬ÁM, and further diluted in either water or HBSS to a final working concentration of 100 nM.
Negative_regulation (inhibitor) of MEK1
8) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737623 Disease Relevance 0.15 Pain Relevance 0
PD98059, a specific inhibitor of MAPKK, did not have a differential effect on the biophysical properties of either Cav1.4nob2 or Cav1.4wt, suggesting that the difference in biophysical properties of these channels is not due to a difference in phosphorylation within these 20 amino acids.
Negative_regulation (inhibitor) of MAPKK
9) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0 Pain Relevance 0
CI-1040 is a non-ATP-competitive inhibitor, that selectively inhibits the activity of MEK1 and MEK2 in in vitro and in vivo mouse tumor models [76].
Negative_regulation (inhibits) of MEK1 associated with cancer
10) Confidence 0.04 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2912314 Disease Relevance 1.42 Pain Relevance 0

General Comments

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