INT127767

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.66
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Atp6v1e1) endosome (Atp6v1e1) transport (Atp6v1e1)
mitochondrion (Atp6v1e1) cytoplasm (Atp6v1e1)
Anatomy Link Frequency
B cells 1
Atp6v1e1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 14 99.56 Very High Very High Very High
Serotonin 364 99.12 Very High Very High Very High
agonist 22 93.52 High High
Kinase C 28 91.48 High High
dorsal root ganglion 8 90.76 High High
adenocard 8 84.96 Quite High
Root ganglion neuron 1 75.00 Quite High
Peripheral nervous system 2 67.84 Quite High
Pain 30 64.00 Quite High
substance P 11 59.20 Quite High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 107 99.72 Very High Very High Very High
Breast Cancer 86 99.10 Very High Very High Very High
Obesity 149 97.48 Very High Very High Very High
Weight Gain 4 95.88 Very High Very High Very High
Apoptosis 24 93.96 High High
Sprains And Strains 63 93.28 High High
Ganglion Cysts 9 90.76 High High
Targeted Disruption 12 86.32 High High
Cancer 17 86.16 High High
Osteoporosis 9 84.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
in the culture supernatant, the viability of B cells was all significantly decreased in E2, CpG and Both groups (Figure 4).
Negative_regulation (decreased) of E2 in B cells
1) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0
We postulate that the observed increase in breast cancer risk may be accounted for by the concurrent decrease in E2 and therefore changes in 5HT2A receptor function immediately prior to parturition.
Negative_regulation (decrease) of E2 associated with breast cancer
2) Confidence 0.20 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.99 Pain Relevance 0.05
Therefore, if E2 is acting on breast cancer in part by serotonin modulation, then we would predict that the decrease in E2 after menopause should increase risk of breast cancer.
Negative_regulation (decrease) of E2 associated with endometriosis (extended), breast cancer and serotonin
3) Confidence 0.20 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.80 Pain Relevance 0.13
E2 action was blocked by the ER antagonist ICI 182,780 (1 microM) in WT mouse.
Negative_regulation (blocked) of E2 associated with antagonist
4) Confidence 0.20 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 15952176 Disease Relevance 0.83 Pain Relevance 0.49
From these calculations, we chose to administer an E2 challenge of 0, 0.5, or 1?
Negative_regulation (administer) of E2
5) Confidence 0.17 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.16 Pain Relevance 0
With reduced levels of E2, 5HT1A receptors are disinhibited and counter the effects of 5HT2A receptor activation.
Negative_regulation (reduced) of E2
6) Confidence 0.17 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0 Pain Relevance 0.53
mediates the inhibitory effect of E2 (after 24 h) on Tac1 expression.
Negative_regulation (effect) of E2
7) Confidence 0.17 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.15
Although self-reactive TH1 cells are present, we hypothesize that E2's suppression of MHC II prevents them from becoming activated, and therefore while sufficient E2 is present they fail to attack tissues.
Negative_regulation (suppression) of E2
8) Confidence 0.17 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.32 Pain Relevance 0.15
Loss of circulating E2 is associated with an increase in adiposity during menopause whereas postmenopausal women who receive E2 replacement therapy do not display the characteristic abdominal weight gain pattern usually associated with menopause [13–15].
Negative_regulation (Loss) of E2 associated with endometriosis (extended) and weight gain
9) Confidence 0.15 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.56 Pain Relevance 0.03

General Comments

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