INT127777

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.80
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Mthfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 129 99.76 Very High Very High Very High
ischemia 7 91.16 High High
headache 6 64.52 Quite High
ergotamine 4 50.64 Quite High
anesthesia 3 50.00 Quite Low
Triptan 7 46.72 Quite Low
Inflammation 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 85 99.96 Very High Very High Very High
Headache 120 99.76 Very High Very High Very High
Migraine With Aura 32 97.64 Very High Very High Very High
Disease 13 97.40 Very High Very High Very High
Migraine Disorders 9 96.24 Very High Very High Very High
Epilepsy 13 94.88 High High
Cv General 4 Under Development 7 91.52 High High
Coronary Artery Disease 3 88.76 High High
Genetic Predisposition To Disease 3 75.00 Quite High
Syndrome 1 9.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After completion of the study, all patients were tested for their MTHFR 677C>T or 1298A>C genotype.
Positive_regulation (tested) of MTHFR
1) Confidence 0.38 Published 2008 Journal Anesthesiology Section Body Doc Link 18580170 Disease Relevance 0 Pain Relevance 0
These findings suggest that migraine may act as mediator in the MTHFR-ischemic stroke pathway with a more prominent effect in the subgroup of patients with sCAD and prompt speculating that the C677T MTHFR polymorphism may be one of the hitherto unknown factors linking migraine to cerebral ischemia.
Positive_regulation (mediator) of MTHFR associated with cv general 4 under development, stroke, ischemia and migraine
2) Confidence 0.06 Published 2011 Journal Stroke Research and Treatment Section Body Doc Link PMC3005862 Disease Relevance 1.65 Pain Relevance 0.72
In contrast, we found synergistic role of ACE (DD)*MTHFR (CT) interaction, showing a positive association in total migraine with aura patients as well as female migraine patients with aura when compared with healthy controls.
Positive_regulation (role) of MTHFR associated with epilepsy and migraine
3) Confidence 0.06 Published 2009 Journal J. Neurol. Sci. Section Abstract Doc Link 19081115 Disease Relevance 1.44 Pain Relevance 0.76
We conclude that the pathogenetic role of the MTHFR T677 allele in migraine is modulated by functional polymorphisms of TS and MTHFD1.
Positive_regulation (role) of MTHFR associated with migraine
4) Confidence 0.04 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15953655 Disease Relevance 0.71 Pain Relevance 0.62

General Comments

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