INT1278

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Context Info
Confidence 0.59
First Reported 1976
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 93
Total Number 106
Disease Relevance 37.66
Pain Relevance 19.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Anatomy Link Frequency
liver 5
blood 4
hepatocytes 4
plasma 3
kidney 3
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 23 100.00 Very High Very High Very High
Morphine 20 100.00 Very High Very High Very High
withdrawal 10 100.00 Very High Very High Very High
Neurotransmitter 5 100.00 Very High Very High Very High
monoamine 1 100.00 Very High Very High Very High
Dynorphin 8 99.98 Very High Very High Very High
Fibrositis 7 99.82 Very High Very High Very High
bradykinin 57 99.80 Very High Very High Very High
metalloproteinase 37 99.76 Very High Very High Very High
Paracetamol 103 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 8 100.00 Very High Very High Very High
Thyroid Disease 3 99.96 Very High Very High Very High
Toxicity 47 99.92 Very High Very High Very High
Disorder Of Lipid Metabolism 28 99.92 Very High Very High Very High
Myoglobinuria 9 99.88 Very High Very High Very High
Diuresis 3 99.84 Very High Very High Very High
Fibromyalgia 5 99.82 Very High Very High Very High
Cancer 17 99.76 Very High Very High Very High
Injury 318 99.62 Very High Very High Very High
Myocardial Infarction 132 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A good correlation was found between the potency of the drugs to inhibit released LDH induced by 30 microM veratridine in neuronal cultures and their binding affinity for the batrachotoxin binding site of Na+ channels in rat cortex synaptosomal preparation.
Negative_regulation (inhibit) of LDH in cortex associated with potency
1) Confidence 0.59 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2175795 Disease Relevance 0.14 Pain Relevance 0.48
LDH activity was high immediately after insertion of the probe, decreased constantly, and then reached a plateau of a relatively low level.
Negative_regulation (decreased) of LDH
2) Confidence 0.58 Published 1996 Journal Anal. Biochem. Section Abstract Doc Link 8660563 Disease Relevance 0.07 Pain Relevance 0.12
Twenty five and 50 micrograms doses of morphine sulfate significantly reduced LDH activity at 1 hr after injection.
Negative_regulation (reduced) of LDH associated with morphine
3) Confidence 0.58 Published 1996 Journal Indian J. Exp. Biol. Section Abstract Doc Link 8698427 Disease Relevance 0 Pain Relevance 0.60
Five and 25 micrograms doses of dynorphin reduced LDH activity both at 1 and 4 hr after treatment.
Negative_regulation (reduced) of LDH associated with dynorphin
4) Confidence 0.58 Published 1996 Journal Indian J. Exp. Biol. Section Abstract Doc Link 8698427 Disease Relevance 0 Pain Relevance 0.61
Reduction of the pH of the perfusion fluid to 6.8 significantly inhibited LDH loss, and at pH 6.4 this leakage was almost completely suppressed.
Negative_regulation (loss) of LDH
5) Confidence 0.53 Published 1996 Journal Kidney Int. Section Abstract Doc Link 8648904 Disease Relevance 0 Pain Relevance 0.17
No LDH loss occurred if the osmotic pressure of the perfusion fluid was raised by 420 mOsm during either Ca(2+)-depletion or Ca(2+)-repletion.
Neg (No) Negative_regulation (loss) of LDH
6) Confidence 0.53 Published 1996 Journal Kidney Int. Section Abstract Doc Link 8648904 Disease Relevance 0 Pain Relevance 0.19
LDH loss was equally suppressed at pH 6.4 only during Ca(2+)-depletion, whereas pH 6.4 was markedly less effective when perfused only during Ca(2+)-repletion.
Negative_regulation (loss) of LDH
7) Confidence 0.53 Published 1996 Journal Kidney Int. Section Abstract Doc Link 8648904 Disease Relevance 0 Pain Relevance 0.16
Interestingly, aqueous Embelia ribes extract exerts its antioxidant effect by decreasing LDH, total cholesterol, triglycerides, LDL-C and lipid peroxide levels, which are implicated in cerebral ischemic reperfusion injury.
Negative_regulation (decreasing) of LDH associated with reperfusion injury and disorder of lipid metabolism
8) Confidence 0.49 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792627 Disease Relevance 0.50 Pain Relevance 0.11
In the MCAO group, treatment with the aqueous extract of Embelia ribes significantly (P < 0.01) decreased the LDH levels, as compared to the MCAO group.
Negative_regulation (decreased) of LDH associated with middle cerebral artery infarction
9) Confidence 0.49 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792627 Disease Relevance 0.71 Pain Relevance 0.07
Koudelova et al. [26] have observed that pretreatment of intoxicated rats with L-carnitine decreased serum LDH activity probably due to membrane stabilizing role of L-carnitine which leads to reduction of LDH leakage from liver.
Negative_regulation (decreased) of LDH in liver
10) Confidence 0.48 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.25 Pain Relevance 0.03
Administration of L-carnitine or/and coenzyme Q10 significantly decreased hepatic total LDH activity compared to CCl4 group.
Negative_regulation (decreased) of LDH
11) Confidence 0.48 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.15 Pain Relevance 0
Administration of L-carnitine or/and coenzyme Q10 (prior to CCl4 injection) significantly decreased hepatic total LDH activity compared to CCl4 control group as shown in Table 3.
Negative_regulation (decreased) of LDH
12) Confidence 0.48 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0 Pain Relevance 0
Paracetamol addition results in a loss of glycogen and lactate dehydrogenase (LDH) from urodele liver cultures and an increase in glucose release, and in LDH loss from kidney cultures.
Negative_regulation (loss) of LDH in kidney associated with paracetamol
13) Confidence 0.44 Published 1982 Journal Toxicology Section Abstract Doc Link 7157388 Disease Relevance 0 Pain Relevance 0.42
Paracetamol addition results in a loss of glycogen and lactate dehydrogenase (LDH) from urodele liver cultures and an increase in glucose release, and in LDH loss from kidney cultures.
Negative_regulation (loss) of LDH in kidney associated with paracetamol
14) Confidence 0.44 Published 1982 Journal Toxicology Section Abstract Doc Link 7157388 Disease Relevance 0 Pain Relevance 0.42
The addition of unpolymerised p-aminophenol resulted in a loss of LDH from urodele and anuran organ cultures, whilst the addition of polymerised p-aminophenol had no such effects.
Negative_regulation (loss) of LDH
15) Confidence 0.44 Published 1982 Journal Toxicology Section Abstract Doc Link 7157388 Disease Relevance 0 Pain Relevance 0.42
Combined treatment with TTX and CPP caused pronounced rightward shifts of LDH deprivation curves.
Negative_regulation (deprivation) of LDH
16) Confidence 0.43 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9294967 Disease Relevance 0.22 Pain Relevance 0.38
The acetaminophen-induced GSH depletion and ensuing lactate dehydrogenase (LDH) leakage were quite modest and delayed in onset, in contrast to that caused by iodoacetamide (IAA) and by diethylmaleate (DEM), 2 well-known depletors of GSH.
Negative_regulation (delayed) of LDH associated with paracetamol
17) Confidence 0.43 Published 1985 Journal Toxicology Section Abstract Doc Link 4060164 Disease Relevance 0 Pain Relevance 0.42
The acetaminophen-induced GSH depletion and ensuing lactate dehydrogenase (LDH) leakage were quite modest and delayed in onset, in contrast to that caused by iodoacetamide (IAA) and by diethylmaleate (DEM), 2 well-known depletors of GSH.
Negative_regulation (depletion) of lactate dehydrogenase associated with paracetamol
18) Confidence 0.43 Published 1985 Journal Toxicology Section Abstract Doc Link 4060164 Disease Relevance 0 Pain Relevance 0.42
After 3-h incubation, the reduction of MTT was significantly decreased compared with control at > or = 1 x 10(-4) M in HAM, at > or = 5 x 10(-4) M in A549 and significantly decreased of LDH retention in the fraction of attached cells in HAM and in A549 at > or = 5 x 10(-4) M.
Negative_regulation (decreased) of LDH in A549
19) Confidence 0.42 Published 2003 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 14571279 Disease Relevance 0.07 Pain Relevance 0.06
Riluzole markedly reduced (-59%) the NMDA-induced LDH release and this protective effect was confirmed by histology.
Negative_regulation (reduced) of LDH
20) Confidence 0.42 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7824190 Disease Relevance 0.33 Pain Relevance 0.19

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