INT12780

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Context Info
Confidence 0.08
First Reported 1986
Last Reported 1995
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.07
Pain Relevance 5.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Fads1) oxidoreductase activity (Fads1) aging (Fads1)
endoplasmic reticulum (Fads1) nucleus (Fads1) response to stress (Fads1)
Anatomy Link Frequency
brain 4
parietal 1
Fads1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 41 100.00 Very High Very High Very High
opioid receptor 11 100.00 Very High Very High Very High
Analgesic 2 99.62 Very High Very High Very High
Delta opioid receptors 7 99.36 Very High Very High Very High
Morphine 11 98.64 Very High Very High Very High
tolerance 2 96.36 Very High Very High Very High
mu opioid receptor 1 96.16 Very High Very High Very High
addiction 2 95.96 Very High Very High Very High
Hippocampus 3 95.76 Very High Very High Very High
Opioid 6 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 65.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neither the specific binding of [3H][D-Pen2,D-Pen5]enkephalin nor [3H]Tyr-D-Ala-Gly-NMePhe-Gly-ol to membranes of frontal or parietal cortices, striatum or hippocampus, prepared from rats chronically treated with AlCl3, were affected.
D-Pen5 Binding (binding) of in parietal associated with hippocampus and enkephalin
1) Confidence 0.08 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477890 Disease Relevance 0.07 Pain Relevance 0.92
[D-Pen2,4'-125I-Phe4,D-Pen5]enkephalin ([125I]DPDPE) is a highly selective radioligand for the delta opioid receptor with a specific activity (2200 Ci/mmol) that is over 50-fold greater than that of tritium-labeled DPDPE analogs. [125I]DPDPE binds to a single site in rat brain membranes with an equilibrium dissociation constant (Kd) value of 421 +/- 67 pM and a receptor density (Bmax) value of 36.4 +/- 2.7 fmol/mg protein.
D-Pen5 Binding (binds) of in brain associated with opioid receptor and enkephalin
2) Confidence 0.06 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1653834 Disease Relevance 0 Pain Relevance 0.37
Conditions for the equilibrium binding to opioid receptor of [3H]sufentanil (mu selective), [3H][D-Pen2,D-Pen5]enkephalin (delta selective), and [3H]U69,593 (kappa selective) were established in membranes from rat brain cerebrum, monkey cortex, or guinea pig cerebellum.
D-Pen5 Binding (binding) of in brain associated with enkephalin and opioid receptor
3) Confidence 0.04 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2898375 Disease Relevance 0 Pain Relevance 0.44
Differences in the binding of [3H][D-Ser2,Thr6]leucine-enkephalin and [3H][D-Pen2,D-Pen5]enkephalin to brain membranes of morphine tolerant-dependent rats.
D-Pen5 Binding (binding) of in brain associated with analgesic, enkephalin and morphine
4) Confidence 0.03 Published 1991 Journal Eur. J. Pharmacol. Section Title Doc Link 1660817 Disease Relevance 0 Pain Relevance 1.51
Ontogenesis of delta-opioid receptors in rat brain using [3H][D-Pen2,D-Pen5]enkephalin as a binding ligand.
D-Pen5 Binding (ligand) of in brain associated with enkephalin and delta opioid receptors
5) Confidence 0.02 Published 1986 Journal Eur. J. Pharmacol. Section Title Doc Link 3024998 Disease Relevance 0 Pain Relevance 0.48
We demonstrate that the major binding determinant for the delta-selective enkephalin-related peptide, [D-Pen2,D-Pen5]enkephalin, resides within the region comprising the transmembrane segments V-VII and the intervening loop regions.
D-Pen5 Spec (determinant) Binding (determinant) of associated with enkephalin
6) Confidence 0.01 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7896813 Disease Relevance 0 Pain Relevance 0.70
When mu sites were blocked with [D-Ala2,(Me)Phe4,Gly(OH)5]enkephalin, the Fab fragments suppressed the binding of [D-Pen2,D-Pen5][3H]enkephalin to the same degree as when the mu binding site was not blocked.
D-Pen5 Binding (binding) of associated with enkephalin
7) Confidence 0.00 Published 1986 Journal J. Biol. Chem. Section Abstract Doc Link 3023329 Disease Relevance 0 Pain Relevance 0.93

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