INT127805

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.21
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (RAF1) cytoplasm (RAF1) cytosol (RAF1)
cell proliferation (RAF1) signal transduction (RAF1) nucleus (RAF1)
Anatomy Link Frequency
neurons 2
RAF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 24 100.00 Very High Very High Very High
agonist 76 99.98 Very High Very High Very High
Calcium channel 28 99.36 Very High Very High Very High
Central nervous system 1 93.04 High High
Spinal cord 5 75.60 Quite High
ischemia 2 70.56 Quite High
palliative 1 61.68 Quite High
GABAergic 12 24.48 Low Low
tetrodotoxin 16 5.00 Very Low Very Low Very Low
imagery 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoid 9 99.58 Very High Very High Very High
Disease 3 86.88 High High
Syndrome 1 84.32 Quite High
Metastasis 1 81.76 Quite High
Neuroendocrine Cancer 1 79.64 Quite High
Injury 2 72.24 Quite High
Hyperplasia 1 72.16 Quite High
Cv General 4 Under Development 1 71.28 Quite High
Breast Cancer 8 5.48 Low Low
Hot Flashes 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of carcinoid tumor cells with ZM336372 resulted in progressive phosphorylation of Raf-1, mitogen-activated protein kinase 1/2, and extracellular signal-regulated kinase 1/2.
Positive_regulation (resulted) of Phosphorylation (phosphorylation) of Raf-1 associated with carcinoid
1) Confidence 0.45 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15956248 Disease Relevance 0.98 Pain Relevance 0.06
agonists stimulated the phosphorylation of PKC, Raf-1 and AKT.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of Raf-1 associated with kinase c and agonist
2) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.56
The activation of these pathways in neurons from mES cells is dependent on calcium mobilization from L-type VGCC, because nifedipine blocks the increase in calcium oscillations and the phosphorylation of PKC, Raf-1 and AKT.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of Raf-1 in neurons associated with kinase c and calcium channel
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.43
The phosphorylation levels of Raf-1 and ERKs were dramatically increased in BDNF-transfected hUCB-MSCs at 7 days of induction (Figure 8C).


Positive_regulation (increased) of Phosphorylation (phosphorylation) of Raf-1
4) Confidence 0.05 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0.23 Pain Relevance 0.12

General Comments

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