INT127819

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Context Info
Confidence 0.28
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 76
Total Number 87
Disease Relevance 18.40
Pain Relevance 13.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Luc7l3) mRNA processing (Luc7l3) plasma membrane (Luc7l3)
nucleus (Luc7l3) DNA binding (Luc7l3) response to stress (Luc7l3)
Anatomy Link Frequency
inner nuclear layer 5
retinas 3
tail 2
third ventricle 2
tanycytes 1
Luc7l3 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 3741 100.00 Very High Very High Very High
Dopamine 2176 99.38 Very High Very High Very High
GABAergic 389 99.04 Very High Very High Very High
GABA receptor 261 98.80 Very High Very High Very High
agonist 816 98.52 Very High Very High Very High
imagery 730 98.52 Very High Very High Very High
antagonist 816 97.24 Very High Very High Very High
Neurotransmitter 667 97.04 Very High Very High Very High
Neuronal excitability 74 96.56 Very High Very High Very High
Action potential 573 96.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 616 100.00 Very High Very High Very High
Aids-related Complex 2480 99.68 Very High Very High Very High
Injury 21 99.44 Very High Very High Very High
Targeted Disruption 293 99.22 Very High Very High Very High
Alopecia 7 99.00 Very High Very High Very High
Ganglion Cysts 766 97.76 Very High Very High Very High
Viral Infection 14 96.88 Very High Very High Very High
Stress 133 96.48 Very High Very High Very High
Wound Healing 4 87.44 High High
Repression 32 85.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was initially expected that the two transgenes (CMV::luc and fos::luc), which were derived from different immediate-early genes, would display distinctly different expression patterns, although the two do have some common gene regulatory elements.
Gene_expression (expression) of luc associated with cytomegalovirus infection
1) Confidence 0.28 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 1.19 Pain Relevance 0
To identify internal organs that express the CMV::luc transgene, both CMV::luc and Hr-CMV mice were dissected 20 minutes after luciferin injection (Fig. 6).
Gene_expression (express) of luc transgene in internal associated with cytomegalovirus infection
2) Confidence 0.28 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 0.82 Pain Relevance 0
The overdosed hairless CMV::luc mice (Hr-CMV) showed luciferase expression in several body regions with clearly detectable signal in the joints of the paws, tail vertebrae, and claws that was not visible in the CMV::luc or fos::luc mice (Fig. 5 and Fig. 2C,2D).
Neg (not) Gene_expression (visible) of luc in tail associated with cytomegalovirus infection
3) Confidence 0.28 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 0.75 Pain Relevance 0
The overdosed hairless CMV::luc mice (Hr-CMV) showed luciferase expression in several body regions with clearly detectable signal in the joints of the paws, tail vertebrae, and claws that was not visible in the CMV::luc or fos::luc mice (Fig. 5 and Fig. 2C,2D).
Gene_expression (2C,2D) of luc in tail associated with cytomegalovirus infection
4) Confidence 0.28 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 0.81 Pain Relevance 0
In this experiment, LUC synthesis should occur if ribosomes initiate translation at the uAUG codons of the uORF and/or the LUC main initiation site with the TnT Quick Coupled Transcription/Translation System (Promega).
Gene_expression (synthesis) of LUC
5) Confidence 0.25 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.20 Pain Relevance 0.22
The autoradiography results (Figure 2B) show that both the uORF-LUC fusion and LUC proteins were expressed at different levels.
Gene_expression (expressed) of LUC
6) Confidence 0.25 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.07 Pain Relevance 0.14
The autoradiography results (Figure 2B) show that both the uORF-LUC fusion and LUC proteins were expressed at different levels.
Gene_expression (expressed) of uORF-LUC
7) Confidence 0.25 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.07 Pain Relevance 0.14
The lower skin expression in Hr-CMV versus CMV::luc mice was perhaps due to loss of hair follicles, pigmentation, or other effects from the albino and hairless mutations.
Gene_expression (expression) of luc in pigmentation associated with cytomegalovirus infection and alopecia
8) Confidence 0.25 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 0.84 Pain Relevance 0.12
It was initially expected that the two transgenes (CMV::luc and fos::luc), which were derived from different immediate-early genes, would display distinctly different expression patterns, although the two do have some common gene regulatory elements.
Gene_expression (expression) of luc associated with cytomegalovirus infection
9) Confidence 0.25 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 1.18 Pain Relevance 0
Although photonic emission from wound sites increased (P < .001) over time with peak values obtained by day 7, no significant (P > .05) effect of relaxin treatment on VEGFR2-luc gene expression was noted at wound sites.
Gene_expression (expression) of VEGFR2-luc associated with injury
10) Confidence 0.24 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15956738 Disease Relevance 0.81 Pain Relevance 0.20
bp fragments of cDNAs, corresponding to LUC or LacZ, respectively: LUC primers, 5?
Gene_expression (primers) of LUC
11) Confidence 0.22 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0 Pain Relevance 0
Thus, the objective of this study was to evaluate the efficacy of relaxin on the development of vascular tissue at wound sites in a novel VEGF receptor 2-luc (VEGFR2-luc) transgenic mouse wound model by monitoring the rate of VEGFR2-luc-mediated gene expression using bioluminescence and real-time imaging.
Gene_expression (expression) of VEGFR2-luc-mediated associated with targeted disruption, injury and imagery
12) Confidence 0.19 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15956738 Disease Relevance 0.79 Pain Relevance 0.15
Localization of rhythmic PER2::LUC expression to the inner nuclear layer is consistent with the persistence of PER2::LUC rhythms in photoreceptor-degenerate mouse retinas [43], and with the persistence of Per2 rhythms in photoreceptor-degenerate RCS retinas [63].
Gene_expression (expression) of LUC in inner nuclear layer
13) Confidence 0.11 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.07 Pain Relevance 0.11
Depolarization with elevated K+ media (4 mM) during 1 mM GABA application partially restored the rhythmic amplitude of PER2::LUC expression (A4/A2 = 0.70 ± 0.04 for vehicle, 0.20 ± 0.05 for GABA, and 0.45 ± 0.07 for 4 mM K+ + GABA; n = 5 each; Figure 10B and 10C), indicating that GABA acts in part through membrane hyperpolarization.
Gene_expression (expression) of LUC associated with gaba
14) Confidence 0.11 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.67
To determine the mechanisms by which GABA suppressed retinal PER2::LUC expression and rhythmicity, we first quantified Per1, Per2, Clock, and Bmal1 mRNA levels 8 h after 3 mM GABA treatment using quantitative real-time PCR.
Gene_expression (expression) of LUC associated with gaba
15) Confidence 0.11 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.50
Within our preparations, all layers of the retina were anatomically intact, and the retinas exhibited robust circadian rhythms of PER2::LUC expression as well as functional light responses in the form of phase resetting.
Gene_expression (expression) of LUC in retinas
16) Confidence 0.11 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.05 Pain Relevance 0.10
Therefore, the substantial reduction in PER2::LUC expression upon GABA treatment is likely due to posttranscriptional regulation.
Gene_expression (expression) of LUC associated with gaba
17) Confidence 0.11 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.54
The wide distribution of PER2::LUC expression across the inner nuclear layer suggests that multiple inner nuclear layer cell types are sources for the rhythmic PER2::LUC signal and are likely participants in the inner retinal clock mechanism.
Gene_expression (expression) of LUC in inner nuclear layer
18) Confidence 0.11 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.10 Pain Relevance 0.12
Similar inner nuclear layer localization of PER2::LUC expression was observed in retinas from C57BL/6J mice as well (unpublished data).
Gene_expression (expression) of LUC in retinas
19) Confidence 0.11 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.20 Pain Relevance 0.08
The pattern of PER2::LUC expression in the current study is consistent with previous single-cell RT-PCR and in situ hybridization studies demonstrating concentration of clock gene transcripts in the inner nuclear layer of the mouse [42,43,62], and immunocytochemistry studies showing predominant localization of PER1, PER2, and CLOCK proteins in the inner nuclear layer as well [13,42].
Gene_expression (expression) of LUC in inner nuclear layer
20) Confidence 0.11 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.04

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