INT12785

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Context Info
Confidence 0.44
First Reported 1981
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.08
Pain Relevance 3.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Mrf) DNA binding (Mrf)
Anatomy Link Frequency
MRF 3
visceral 1
blood 1
neurons 1
arterioles 1
Mrf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methadone 7 98.48 Very High Very High Very High
Pain 2 96.88 Very High Very High Very High
Hippocampus 1 95.00 High High
cerebral cortex 4 94.24 High High
tail-flick 6 94.08 High High
tetrodotoxin 9 93.88 High High
midbrain 2 93.08 High High
Sciatic nerve 1 89.52 High High
Spinal cord 1 80.64 Quite High
narcan 4 80.08 Quite High
Disease Link Frequency Relevance Heat
Pain 2 96.88 Very High Very High Very High
Increased Venous Pressure Under Development 8 81.92 Quite High
Aging 1 80.00 Quite High
Nociception 6 78.20 Quite High
Frailty 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the dam's MRF and Hyp had no marked influence on the blood flow in the fetal brain.
Positive_regulation (Activation) of MRF in blood
1) Confidence 0.44 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7653643 Disease Relevance 0 Pain Relevance 0.16
Although MRF neuron responses failed to be evoked with direct (mechanical and electrical nerve) pelvic visceral stimuli, acute chemical irritation of the urinary bladder produced a significant increase in the number of MRF neurons responsive to stimulation of VAG-abd.
Positive_regulation (increase) of MRF in visceral
2) Confidence 0.41 Published 2007 Journal J. Neurotrauma Section Abstract Doc Link 17610360 Disease Relevance 0 Pain Relevance 0.07
Intravenous administration of methadone (0.2-0.5 mg/kg) markedly increased the threshold for cortical desynchronization by stimulation of the MRF.
Positive_regulation (stimulation) of MRF associated with methadone
3) Confidence 0.41 Published 1981 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 6169511 Disease Relevance 0 Pain Relevance 0.65
However, the basal thresholds obtained by direct stimulation of the MRF failed to show a significant age effect, suggesting that the registration of pain is not different between young and aged rats.
Positive_regulation (stimulation) of MRF in MRF associated with pain
4) Confidence 0.41 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 16759686 Disease Relevance 0.46 Pain Relevance 0.89
The dam's blood pressure was increased immediately after the beginning of MRF or Hyp stimulation.
Positive_regulation (stimulation) of MRF in MRF
5) Confidence 0.32 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7653643 Disease Relevance 0 Pain Relevance 0.17
It was also found that a significant proportion of SRV units was antidromically activated by electrical stimulation of the mesencephalic reticular formation (MRF), and retrogradely labelled neurons were found in the SRV after HRP injection into the MRF.
Positive_regulation (stimulation) of MRF in neurons
6) Confidence 0.30 Published 1991 Journal Neurosci. Res. Section Abstract Doc Link 1653919 Disease Relevance 0.15 Pain Relevance 0
Bilateral stimulation of the mesencephalic reticular formation (MRF) produced a frequency-dependent increase in cortical VIP release over the range of 60-100 Hz.
Positive_regulation (stimulation) of MRF in MRF
7) Confidence 0.11 Published 1985 Journal Brain Res. Section Abstract Doc Link 2982463 Disease Relevance 0 Pain Relevance 0.37
Activation of the cortex by either direct electrical stimulation or indirectly by stimulation of the mesencephalic reticular formation (MRF) resulted in a rapid dilatation of pial arterioles and venules.
Positive_regulation (stimulation) of MRF in venules
8) Confidence 0.09 Published 1987 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 3108270 Disease Relevance 0.23 Pain Relevance 0.36
Activation of the cortex by either direct electrical stimulation or indirectly by stimulation of the mesencephalic reticular formation (MRF) resulted in a rapid dilatation of pial arterioles and venules.
Positive_regulation (stimulation) of MRF in arterioles
9) Confidence 0.03 Published 1987 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 3108270 Disease Relevance 0.23 Pain Relevance 0.36

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