INT127889

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2008
Negated 2
Speculated 2
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 6.70
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYP19A1) small molecule metabolic process (CYP19A1) endoplasmic reticulum (CYP19A1)
cytoplasm (CYP19A1)
Anatomy Link Frequency
body 6
plasma 2
CYP19A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 40 100.00 Very High Very High Very High
Acupuncture 1 82.80 Quite High
Osteoarthritis 1 76.52 Quite High
cytokine 8 75.00 Quite High
Analgesic 1 71.32 Quite High
Inflammation 10 70.76 Quite High
agonist 3 35.64 Quite Low
antagonist 1 34.72 Quite Low
cva 8 30.48 Quite Low
COX2 8 25.00 Low Low
Disease Link Frequency Relevance Heat
Breast Cancer 201 99.76 Very High Very High Very High
Cancer 208 99.36 Very High Very High Very High
Osteoporosis 14 99.24 Very High Very High Very High
Malignant Neoplastic Disease 5 98.96 Very High Very High Very High
INFLAMMATION 20 97.60 Very High Very High Very High
Obesity 2 97.48 Very High Very High Very High
Peripheral Arterial Disease 7 94.72 High High
Targeted Disruption 17 86.92 High High
Endometriosis (extended) 10 85.64 High High
Apoptosis 6 77.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, these results suggest that the siRNAs and novel sulfonanilides targeting aromatase expression may be valuable tools for selective regulation of aromatase in breast cancer.
Regulation (targeting) of Gene_expression (expression) of aromatase associated with breast cancer
1) Confidence 0.62 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17616393 Disease Relevance 0.38 Pain Relevance 0
Complex regulation of aromatase expression in human tissues involves alternative promoter sites that provide tissue-specific control.
Regulation (regulation) of Gene_expression (expression) of aromatase
2) Confidence 0.62 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17616393 Disease Relevance 0.35 Pain Relevance 0.15
Regulation of aromatase expression in human tissues is quite complex, involving alternative promoter sites that provide tissue-specific control.
Regulation (Regulation) of Gene_expression (expression) of aromatase
3) Confidence 0.62 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.38 Pain Relevance 0.11
The effects of NSAIDs (ibuprofen, piroxicam, and indomethacin), a COX-1 selective inhibitor (SC-560), and COX-2 selective inhibitors (celecoxib, niflumic acid, nimesulide, NS-398, and SC-58125) on aromatase activity and CYP19 expression were investigated in breast cancer cell culture systems.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of CYP19 associated with breast cancer and cinod
4) Confidence 0.45 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.51 Pain Relevance 0.38
The effects of NSAIDs (ibuprofen, piroxicam, and indomethacin), a COX-1 selective inhibitor (SC-560), and COX-2 selective inhibitors (celecoxib, niflumic acid, nimesulide, NS-398, and SC-58125) on aromatase activity and CYP19 expression were investigated in breast cancer cell culture systems.
Spec (investigated) Regulation (effects) of Gene_expression (activity) of aromatase associated with breast cancer and cinod
5) Confidence 0.45 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.51 Pain Relevance 0.38
Moreover, levels of estradiol in breast tumor tissue have been shown to be higher than those in normal breast tissue distant from the tumor [14,15], and the major enzymes involved in estrogen synthesis – aromatase, sulphatase, and 17?
Regulation (involved) of Gene_expression (synthesis) of aromatase associated with cancer and breast cancer
6) Confidence 0.44 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2279135 Disease Relevance 0.97 Pain Relevance 0
Molecular differences between anastrozole, letrozole and exemestane affect their selectivity for the aromatase enzyme and thus their capability in the inhibition of total-body-aromatization and, as a result, plasma estrogen suppression (Budzar and Howel 2001; Smith and Dowsett 2003).
Regulation (affect) of Gene_expression (selectivity) of aromatase enzyme in plasma
7) Confidence 0.32 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 0.05 Pain Relevance 0
Median aromatase values did not change significantly with letrozole or tamoxifen treatment; however, changes in score did occur in individual cases, with more noticeable effects observed in letrozole-treated patients [41].
Neg (not) Regulation (change) of Gene_expression (values) of aromatase
8) Confidence 0.21 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.76 Pain Relevance 0
Aromatase is found in several tissues in the body and aromatase (CYP19) gene expression is regulated in a tissue-specific manner via use of alternative promoters.
Regulation (regulated) of Gene_expression (expression) of aromatase in body
9) Confidence 0.14 Published 2006 Journal Anti-cancer agents in medicinal chemistry Section Abstract Doc Link 16712450 Disease Relevance 0.84 Pain Relevance 0
Aromatase is found in several tissues in the body and aromatase (CYP19) gene expression is regulated in a tissue-specific manner via use of alternative promoters.
Regulation (regulated) of Gene_expression (expression) of aromatase in body
10) Confidence 0.11 Published 2006 Journal Minerva Endocrinol. Section Abstract Doc Link 16498361 Disease Relevance 0.36 Pain Relevance 0.05
Gene expression of the aromatase was not affected by Buthus martensi Karsch in FLG 29.1 and hOB cells.
Neg (not) Regulation (affected) of Gene_expression (expression) of aromatase
11) Confidence 0.11 Published 2006 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 16873093 Disease Relevance 0.65 Pain Relevance 0.25
Alternatively, expression of P450 aromatase in the skin and local aromatization of androgens to estrogens could be responsible for body color variation.
Regulation (responsible) of Gene_expression (expression) of aromatase in body
12) Confidence 0.04 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592273 Disease Relevance 0.09 Pain Relevance 0
Therefore, regulation of mammary aromatase synthesis by COX/PG signaling is most likely to be important in the context of postmenopausal breast cancer.
Regulation (regulation) of Gene_expression (synthesis) of aromatase associated with breast cancer
13) Confidence 0.04 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.84 Pain Relevance 0.08

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