INT1279

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Context Info
Confidence 0.30
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.10
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cox6c) biological_process (Cox6c)
Anatomy Link Frequency
neurons 2
lateral 1
central nervous system 1
Cox6c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 5 100.00 Very High Very High Very High
Clonidine 8 99.98 Very High Very High Very High
monoamine 1 99.92 Very High Very High Very High
Central nervous system 1 99.68 Very High Very High Very High
Action potential 8 99.14 Very High Very High Very High
IPN 2 99.00 Very High Very High Very High
substance P 9 98.56 Very High Very High Very High
Morphine 1 96.40 Very High Very High Very High
Dopamine 5 94.72 High High
Enkephalin 4 91.28 High High
Disease Link Frequency Relevance Heat
Hypoxia 5 99.20 Very High Very High Very High
Parkinson's Disease 16 97.52 Very High Very High Very High
Death 8 97.16 Very High Very High Very High
Sleep Disorders 8 96.72 Very High Very High Very High
Unconsciousness 1 95.92 Very High Very High Very High
Sepsis 33 89.60 High High
Nerve Compression Syndromes 90 88.48 High High
Disease 4 81.00 Quite High
Ganglion Cysts 144 80.88 Quite High
INFLAMMATION 9 77.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At present, scientific mechanisms for these effects are unknown, but inhibition of cytochrome oxidase in the central nervous system (CNS) by sulfide has been suggested.
Negative_regulation (inhibition) of cytochrome oxidase in central nervous system associated with central nervous system
1) Confidence 0.30 Published 1999 Journal Toxicol. Sci. Section Abstract Doc Link 10478866 Disease Relevance 0.44 Pain Relevance 0.10
Acute treatment with clonidine decreased the citrate synthase, NADH-cytochrome c reductase and cytochrome oxidase activities only in the same type of mitochondria, i.e. synaptic "heavy" mitochondria.
Negative_regulation (decreased) of cytochrome oxidase associated with clonidine
2) Confidence 0.19 Published 1989 Journal Farmaco Section Abstract Doc Link 2775415 Disease Relevance 0 Pain Relevance 0.48
Acute treatment with piracetam decreased citrate synthase, glutamate dehydrogenase, NADH-cytochrome c reductase and cytochrome oxidase activities only in the "heavy" mitochondria obtained from synaptosomes.
Negative_regulation (decreased) of cytochrome oxidase associated with glutamate
3) Confidence 0.19 Published 1989 Journal Farmaco Section Abstract Doc Link 2775415 Disease Relevance 0 Pain Relevance 0.44
Bilateral neonatal FR lesions resulted in a permanent loss of ChAT and cytochrome oxidase staining throughout the IPN and of SP in the lateral and rostral subnuclei.
Negative_regulation (loss) of cytochrome oxidase in lateral associated with ipn and substance p
4) Confidence 0.15 Published 1987 Journal Brain Res. Section Abstract Doc Link 2445414 Disease Relevance 0 Pain Relevance 0.65
In both intact and hemiparkinsonian rats, this stimulation was found to induce c-fos protein expression but to decrease cytochrome oxidase subunit I mRNA levels in STN neurons.
Negative_regulation (decrease) of cytochrome oxidase in neurons
5) Confidence 0.12 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12077209 Disease Relevance 0.08 Pain Relevance 0.40
Marker enzymes used to evaluate the subcellular fractions included cytochrome oxidase, monoamine oxidase, D-amino acid oxidase, acid phosphatase, glucose-6-phosphatase, ethyl morphine demethylase, and lactate dehydrogenase.
Negative_regulation (evaluate) of cytochrome oxidase associated with morphine and monoamine
6) Confidence 0.12 Published 1976 Journal Prep. Biochem. Section Abstract Doc Link 184448 Disease Relevance 0 Pain Relevance 0.15
Loss of peripheral trophic factors and decreased depolarizing activity (action potential discharge) were proposed to contribute to decreased cytochrome oxidase activity in these cells [57].
Negative_regulation (decreased) of cytochrome oxidase associated with action potential
7) Confidence 0.09 Published 2008 Journal Mol Pain Section Body Doc Link PMC2630978 Disease Relevance 0.41 Pain Relevance 0.24
Using this method, chronic decreases in cytochrome oxidase activity were observed after axotomy of neurons within sensory ganglia [57,58].
Negative_regulation (decreases) of cytochrome oxidase in neurons
8) Confidence 0.09 Published 2008 Journal Mol Pain Section Body Doc Link PMC2630978 Disease Relevance 0.52 Pain Relevance 0.26
Formic acid disrupts mitochondrial electron transport and energy production by inhibiting cytochrome oxidase activity.
Negative_regulation (inhibiting) of cytochrome oxidase
9) Confidence 0.02 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900059 Disease Relevance 0.65 Pain Relevance 0.06
Early cellular hypoxia may favour the competitive NO-mediated inhibition of cytochrome oxidase, contributing to the earlier, if not greater, development of mitochondrial dysfunction [12].
Negative_regulation (inhibition) of cytochrome oxidase associated with parkinson's disease and hypoxia
10) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1751057 Disease Relevance 1.01 Pain Relevance 0.04

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