INT127900

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Context Info
Confidence 0.80
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 7.99
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (EIF2AK3) cell (EIF2AK3) response to stress (EIF2AK3)
cytoplasm (EIF2AK3)
Anatomy Link Frequency
fat 2
reticulum 1
EIF2AK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 7 98.40 Very High Very High Very High
Hyperalgesia 1 96.36 Very High Very High Very High
cocaine 292 95.72 Very High Very High Very High
cINOD 15 87.64 High High
Central nervous system 32 85.00 Quite High
nMDA receptor 3 75.00 Quite High
Root ganglion neuron 2 75.00 Quite High
Potency 5 71.28 Quite High
Dopamine 1 67.04 Quite High
Inflammatory response 50 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 444 99.98 Very High Very High Very High
Diabetes Mellitus 29 99.74 Very High Very High Very High
Stress 577 99.54 Very High Very High Very High
Obesity 9 99.46 Very High Very High Very High
Nociception 7 97.00 Very High Very High Very High
Hyperalgesia 3 96.36 Very High Very High Very High
Diarrhoea 1 94.56 High High
Apoptosis 193 94.52 High High
Fatigue 3 93.88 High High
Fatty Liver 51 91.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mitogen activated protein kinases such as phosphorylated extracellular signal-regulated kinase-1 and -2 (pERK 1/2) have been recently demonstrated to play an important role in somatic nociception and hyperalgesia.
Phosphorylation (phosphorylated) of pERK associated with nociception and hyperalgesia
1) Confidence 0.80 Published 2005 Journal Neuroscience Section Abstract Doc Link 15964695 Disease Relevance 0.48 Pain Relevance 0.20
Celecoxib caused phosphorylation of eukaryotic translation initiation factor 2 kinase (PERK) and eukaryotic initiation factor-2alpha (eIF2alpha) and production of activating transcription factor (ATF)4 mRNA.
Phosphorylation (phosphorylation) of PERK
2) Confidence 0.80 Published 2006 Journal Oncogene Section Abstract Doc Link 16205636 Disease Relevance 0.75 Pain Relevance 0.47
Secondly, ICP34.5 takes part in blocking the stress response of endoplasmic reticulum (ER) via phosphorilation of ER resident kinase PERK [19].
Phosphorylation (phosphorilation) of PERK in reticulum associated with stress
3) Confidence 0.79 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.39 Pain Relevance 0
Upon activation, PERK phosphorylates eIF2?
Phosphorylation (phosphorylates) of PERK
4) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.40 Pain Relevance 0
phosphorylation on PERK.
Phosphorylation (phosphorylation) of PERK
5) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.35 Pain Relevance 0.05
The suppression of protein translation via phosphorylation of both PERK and eIF2?
Phosphorylation (phosphorylation) of PERK
6) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.38 Pain Relevance 0
The canonical pathway for ER stress activation of the UPR begins with the dissociation of BiP from PERK, resulting in PERK autophosphorylation.
Phosphorylation (autophosphorylation) of PERK associated with stress
7) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.40 Pain Relevance 0
In addition to transiently suppressing protein translation during ER stress, a second function of PERK phosphorylation of eIF2?
Phosphorylation (phosphorylation) of PERK associated with stress
8) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.41 Pain Relevance 0.03
Indeed, signs of ER stress have been detected in hepatocytes of mice fed high fat diets or ob/ob mice (mice deficient in leptin that are obese and diabetics), including phosphorylation of pancreatic ER kinase (PERK), translation initiation factor 2 (TRAF2) and JNK.
Phosphorylation (phosphorylation) of pancreatic ER kinase in fat associated with stress, diabetes mellitus and obesity
9) Confidence 0.28 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.34 Pain Relevance 0
Indeed, signs of ER stress have been detected in hepatocytes of mice fed high fat diets or ob/ob mice (mice deficient in leptin that are obese and diabetics), including phosphorylation of pancreatic ER kinase (PERK), translation initiation factor 2 (TRAF2) and JNK.
Phosphorylation (phosphorylation) of PERK in fat associated with stress, diabetes mellitus and obesity
10) Confidence 0.28 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.35 Pain Relevance 0
Protein expression was measured by 4°C overnight immunoblotting with diluted antibodies: extracellular signal-regulated kinase 2 (mouse monoclonal ERK2, 1:1000; Santa Cruz Biotechnology, Santa Cruz, CA), phosphorylated ERK1/2 (mouse monoclonal pERK, 1:500; Santa Cruz Biotechnology), COX-2 (goat polyclonal, 1:500; Santa Cruz Biotechnology) iNOS (rabbit polyclonal, 1:500; Santa Cruz Biotechnology) and phosphorylated CREB (rabbit polyclonal, 1:1000; AbCam, Cambridge, MA).
Phosphorylation (phosphorylated) of pERK
11) Confidence 0.18 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0 Pain Relevance 0
Protein expression was measured by 4°C overnight immunoblotting with diluted antibodies: extracellular signal-regulated kinase 2 (mouse monoclonal ERK2, 1:1000; Santa Cruz Biotechnology, Santa Cruz, CA), phosphorylated ERK1/2 (mouse monoclonal pERK, 1:500; Santa Cruz Biotechnology), COX-2 (goat polyclonal, 1:500; Santa Cruz Biotechnology) iNOS (rabbit polyclonal, 1:500; Santa Cruz Biotechnology) and phosphorylated CREB (rabbit polyclonal, 1:1000; AbCam, Cambridge, MA).
Phosphorylation (phosphorylated) of pERK
12) Confidence 0.18 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0 Pain Relevance 0
Upon ER stress such as ER oxidation, the ER sensor protein PERK phosphorylates eIF2?
Phosphorylation (phosphorylates) of PERK associated with stress
13) Confidence 0.13 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.53 Pain Relevance 0.43
Interestingly, in an analysis of a subgroup of treated patients (n = 33), pretreatment tumor phosphorylated ERK (pERK) levels were correlated with the TTP.
Phosphorylation (phosphorylated) of pERK associated with cancer
14) Confidence 0.07 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721397 Disease Relevance 1.21 Pain Relevance 0.04

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