INT12791

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Context Info
Confidence 0.62
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.20
Pain Relevance 4.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xdh) oxidoreductase activity (Xdh) extracellular region (Xdh)
peroxisome (Xdh) cytoplasm (Xdh)
Anatomy Link Frequency
vasculature 1
liver 1
spinal cord 1
muscle 1
Xdh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 45 99.92 Very High Very High Very High
B1 receptor 273 99.60 Very High Very High Very High
adenocard 2 99.60 Very High Very High Very High
anesthesia 4 99.26 Very High Very High Very High
Pain 92 97.52 Very High Very High Very High
Inflammation 25 97.16 Very High Very High Very High
nMDA receptor 42 96.56 Very High Very High Very High
allodynia 115 96.40 Very High Very High Very High
central sensitization 44 95.84 Very High Very High Very High
dexamethasone 7 95.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxicity 2 99.12 Very High Very High Very High
Pressure And Volume Under Development 57 98.40 Very High Very High Very High
Hyperlipidemia 14 98.16 Very High Very High Very High
Pain 98 97.52 Very High Very High Very High
Hypertension 21 97.48 Very High Very High Very High
Injury 61 97.32 Very High Very High Very High
INFLAMMATION 30 97.16 Very High Very High Very High
Diabetes Mellitus 138 96.60 Very High Very High Very High
Neuropathic Pain 151 96.40 Very High Very High Very High
Increased Venous Pressure Under Development 15 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After general anesthesia, cremaster muscle was collected for analysis of XO and xanthine dehydrogenase (XDH) activities.
Gene_expression (analysis) of xanthine dehydrogenase in muscle associated with anesthesia
1) Confidence 0.62 Published 2003 Journal Microvasc. Res. Section Abstract Doc Link 12826072 Disease Relevance 0.68 Pain Relevance 0.30
Thus, xanthine oxidase is an important source of reactive oxygen species that contributes to neurovascular dysfunction in experimental diabetes.
Gene_expression (source) of xanthine oxidase associated with diabetes mellitus
2) Confidence 0.59 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17291486 Disease Relevance 0.90 Pain Relevance 0.33
The effects of these drugs were also studied on O2- production by the xanthine-xanthine oxidase and reduced nicotinamide adenine dinucleotide phosphate (NADPH)-NADPH oxidase systems.
Gene_expression (production) of xanthine-xanthine oxidase
3) Confidence 0.53 Published 1991 Journal Chem. Pharm. Bull. Section Abstract Doc Link 1654219 Disease Relevance 0.22 Pain Relevance 0.39
The aim of this experimental study was to investigate the effects of erdosteine, an antioxidant agent, on doxorubicin (DXR)-induced cardio-toxicity through nitric oxide (NO) levels, collagen synthesis, xanthine oxidase (XO) and adenosine deaminase (ADA) activities in rats.
Gene_expression (synthesis) of xanthine oxidase associated with toxicity and adenocard
4) Confidence 0.40 Published 2003 Journal Toxicology Section Abstract Doc Link 12965118 Disease Relevance 0.10 Pain Relevance 0.16
levels with allopurinol and its partial inhibition with L-NAME suggest multiple sources of ROS in this model, including xanthine oxidase and uncoupling eNOS.
Gene_expression (sources) of xanthine oxidase
5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.66 Pain Relevance 0.16
Xanthine oxidase was also proposed as a source of ROS in the vasculature in models of hypertension [42].
Gene_expression (source) of Xanthine oxidase in vasculature associated with pressure and volume under development
6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.66 Pain Relevance 0.16
Xanthine oxidase and uncoupling eNOS are unlikely involved in O2•?
Gene_expression (involved) of Xanthine oxidase
7) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.69 Pain Relevance 0.54
First, in order to investigate the role of superoxide produced by xanthine oxidase (XO), which has drawn attention as a main ROS that causes post-IR injury tissue damage in the CPIP model, the degree of NMDA receptor phosphorylation in the spinal cord was measured in the rats, which were given allopurinol (an XO inhibitor) to examine the involvement of superoxide mediated by XO in central sensitization by NMDA receptor phosphorylation.
Gene_expression (produced) of xanthine oxidase in spinal cord associated with pain, central sensitization, nmda receptor, injury and spinal cord
8) Confidence 0.06 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2884210 Disease Relevance 1.06 Pain Relevance 1.29
The present data suggest the contribution of superoxide, produced via xanthine oxidase, and the participation of superoxide and nitric oxide as a precursor of peroxynitrite in NMDA mediated central sensitization.
Gene_expression (produced) of xanthine oxidase associated with central sensitization
9) Confidence 0.05 Published 2010 Journal The Korean Journal of Pain Section Abstract Doc Link PMC2884210 Disease Relevance 1.04 Pain Relevance 1.06
In contrast, the serum LDL-cholesterol levels and liver xanthine oxidase (XO) activity in WJ diet groups were significantly decreased.
Gene_expression (levels) of xanthine oxidase in liver
10) Confidence 0.03 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2892354 Disease Relevance 0.27 Pain Relevance 0
Among various sources of superoxide such as NADPH oxidase, xanthine oxidase, lipoxygenase, mitochondrial oxidase, and nitric oxide synthase, NADPH oxidase appears to be the principal source of superoxide in several animal models.
Gene_expression (source) of xanthine oxidase
11) Confidence 0.02 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2991579 Disease Relevance 0.64 Pain Relevance 0.14
For nitroglycerin, several bioactivating systems have been proposed during the last decades including xanthine oxidoreductase, glutathione-S-transferases, and cytochrome P450 enzymes (for review see [32, 34]).
Gene_expression (xanthine oxidoreductase) of xanthine oxidoreductase
12) Confidence 0.01 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC3014692 Disease Relevance 0.29 Pain Relevance 0

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