INT127914

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 26.87
Pain Relevance 4.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (AGTR2) signal transducer activity (AGTR2)
Anatomy Link Frequency
fibroblasts 2
retina 1
pancreas 1
brain 1
carotid body 1
AGTR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 97 100.00 Very High Very High Very High
Inflammation 1171 99.76 Very High Very High Very High
anesthesia 4 99.46 Very High Very High Very High
fibrosis 77 98.20 Very High Very High Very High
Inflammatory response 32 93.32 High High
bradykinin 45 91.04 High High
agonist 97 81.44 Quite High
Inflammatory mediators 58 80.52 Quite High
cytokine 144 80.36 Quite High
cINOD 48 61.16 Quite High
Disease Link Frequency Relevance Heat
Disease 475 99.80 Very High Very High Very High
INFLAMMATION 1251 99.76 Very High Very High Very High
Diabetic Retinopathy 253 99.60 Very High Very High Very High
Pre-eclampsia 66 99.38 Very High Very High Very High
Hypoxia 234 99.26 Very High Very High Very High
Leukostasis 40 99.08 Very High Very High Very High
Diabetes Mellitus 157 99.00 Very High Very High Very High
Cv General 2 Under Development 3 98.70 Very High Very High Very High
Cardiovascular Disorder Under Development 16 98.52 Very High Very High Very High
Injury 150 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Severe hypotension after induction of general anesthesia in a patient receiving an angiotensin II receptor antagonist and an alpha-blocker].
Gene_expression (antagonist) of angiotensin II receptor associated with anesthesia, cv general 2 under development and antagonist
1) Confidence 0.68 Published 2005 Journal Masui Section Title Doc Link 15966388 Disease Relevance 0.37 Pain Relevance 0.45
Indeed it is anticipated that prolonged expression of AT1 combined with a lack of AT2 expression results in sustained chronic inflammation and fibrosis.
Gene_expression (expression) of AT2 associated with fibrosis and inflammation
2) Confidence 0.41 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.93 Pain Relevance 0.41
governs many hypoxia driven transcriptions [43], its control of AT1b and AT2 expression can be hypothesized.
Gene_expression (expression) of AT2 associated with hypoxia
3) Confidence 0.41 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.19 Pain Relevance 0.04
The expression of AT1 and AT2 receptors has been studied during the development and regression of hypoxic pulmonary hypertension [41].
Gene_expression (expression) of AT2 associated with hypoxia and hypertension
4) Confidence 0.41 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.07 Pain Relevance 0.04
The expression of AT1 and AT2 receptors on fibroblasts present in cardiac fibrosis is investigated [79].
Spec (investigated) Gene_expression (expression) of AT2 in fibroblasts associated with fibrosis and cardiovascular disorder under development
5) Confidence 0.41 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.20 Pain Relevance 0.31
The expression of AT2 is believed to protect the cell from apoptosis and this effect has been demonstrated in the brain when AT1 is antagonized [42].
Gene_expression (expression) of AT2 in brain associated with apoptosis
6) Confidence 0.41 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.02 Pain Relevance 0.04
The release of ACE and extended expression of AT1 and AT2 during the healing process following vascular injury helps to answer this question [65].
Gene_expression (expression) of AT2 associated with vasculitis
7) Confidence 0.41 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.35 Pain Relevance 0.17
Significant evidence has been shown that AT1 receptors are upregulated during disease and that AT2 receptor expression follows behind AT1 expression during injury and healing.
Gene_expression (expression) of AT2 receptor associated with injury and disease
8) Confidence 0.41 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.86 Pain Relevance 0.37
An investigation of the action of IGF-1 in the regulation of expression of AT2 leads to an explanation of this association.


Gene_expression (expression) of AT2
9) Confidence 0.35 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.71 Pain Relevance 0.29
AT2 Angiotensin II Type 2 receptor
Gene_expression (receptor) of AT2
10) Confidence 0.35 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.17 Pain Relevance 0.18
Hypoxia has been demonstrated to induce the expression of both AT1b (AT1a and AT1b are subsets of AT1) and AT2 receptors in the rat carotid body and pancreas [39,40].
Gene_expression (expression) of AT2 in pancreas associated with hypoxia
11) Confidence 0.35 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.13 Pain Relevance 0.05
These types of fibroblast are noted for their expression of AT1 and AT2 receptors.
Gene_expression (expression) of AT2 in fibroblast
12) Confidence 0.32 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.99 Pain Relevance 0.29
Interestingly, the continuance in the presence of pro-inflammatory signals serves to delay expression of AT2.
Gene_expression (expression) of AT2 associated with inflammation
13) Confidence 0.32 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.78 Pain Relevance 0.36
AT2 Angiotensin II Type 2 receptor
Gene_expression (receptor) of Angiotensin II Type 2
14) Confidence 0.31 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.17 Pain Relevance 0.18
Herse et al., has found an upregulation of decidual AT1R mRNA in preeclampsia; in contrast, the vasodilator AT2 receptor gene expression is present in 4% of the preeclamptic versus 60% of controls[135,137].
Gene_expression (expression) of AT2 associated with pre-eclampsia
15) Confidence 0.30 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.16 Pain Relevance 0.08
This is confirmed in a separate study of AT2 expression in proliferating cells.
Gene_expression (expression) of AT2
16) Confidence 0.28 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.77 Pain Relevance 0.36
1 and bFGF are shown as powerful inhibitors of AT2 expression, whilst IGF-1 is shown to induce the expression of AT2 [80].
Gene_expression (expression) of AT2
17) Confidence 0.28 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.61 Pain Relevance 0.35
The ovine placenta expresses both angiotensin receptors, with predominance of the AT1-R in early pregnancy, and similar expressions of the AT1 and the AT2-R in late pregnancy.
Gene_expression (expressions) of AT2 in placenta
18) Confidence 0.24 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.21 Pain Relevance 0
in the vitreous fluid of patients with PDR [101], and AT1 and AT2 were
Gene_expression (were) of AT2 associated with diabetic retinopathy
19) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 1.16 Pain Relevance 0.07
Furthermore, AT1 and AT2, AII, and its
Gene_expression (Furthermore) of AT2
20) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 1.17 Pain Relevance 0.09

General Comments

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