INT127970

Context Info Confidence 0.01 First Reported 2004 Last Reported 2004 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.24 Pain Relevance 0.24

small molecule metabolic process (HEXB) cell death (HEXB) carbohydrate metabolic process (HEXB) lysosome (HEXB)

Anatomy Link Frequency reticulum 1 HEXB (Homo sapiens)

Pain Link Frequency Relevance Heat Migraine 5 84.52 depression 1 35.60

Disease Link Frequency Relevance Heat Migraine With Aura 3 84.92 Headache 2 41.36 Depression 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Metabolic labeling studies showed that the mutants were synthesized and associated with the beta-subunit, except for the alpha2HW887R mutant, which was poorly synthesized, and the alpha1BW890R, which was partially retained in the endoplasmic reticulum. [3H]ouabain binding showed the presence of the alpha2HR689Q and alpha2HM731T at the membrane, whereas the alpha2HL764P and alpha2HW887R could not be detected.

beta-subunit Neg (except) Binding (associated) of in reticulum

1) Confidence 0.01 Published 2004 Journal Neuromolecular Med. Section Abstract Doc Link 15970628 Disease Relevance 0.24 Pain Relevance 0.24

General Comments

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