INT127975

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 11.25
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SPP1) extracellular region (SPP1) cell adhesion (SPP1)
cytoplasm (SPP1)
Anatomy Link Frequency
osteoblast 1
SPP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 94.12 High High
Pain 15 77.36 Quite High
metalloproteinase 90 76.60 Quite High
Inflammation 6 75.00 Quite High
dexamethasone 14 59.32 Quite High
corticosteroid 6 49.28 Quite Low
Central nervous system 19 47.72 Quite Low
Spinal cord 8 11.24 Low Low
fibrosis 72 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 105 99.74 Very High Very High Very High
Apoptosis 35 99.58 Very High Very High Very High
Scoliosis 314 99.44 Very High Very High Very High
Sprains And Strains 24 99.32 Very High Very High Very High
Targeted Disruption 6 98.76 Very High Very High Very High
Metastasis 113 97.32 Very High Very High Very High
Pancreatic Cancer 9 96.76 Very High Very High Very High
Cancer 293 96.68 Very High Very High Very High
Cytomegalovirus Infection 18 96.08 Very High Very High Very High
Pancreatitis 4 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory effect of osteopontin on MMP-1 was also observed at the protein level by Western blot analysis.
Negative_regulation (effect) of osteopontin
1) Confidence 0.42 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0 Pain Relevance 0
In a study of 37 strains of Zygomycetes, posaconazole was effective against Mucor spp., Rhizopus spp., Absidia spp., Rhizomucor spp., C. bertholletiae, and A. elegans (Sun et al 2002; Kwon and Mylonakis 2007).
Negative_regulation (effective) of spp associated with sprains and strains
2) Confidence 0.41 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621380 Disease Relevance 0.89 Pain Relevance 0
In a study of 37 strains of Zygomycetes, posaconazole was effective against Mucor spp., Rhizopus spp., Absidia spp., Rhizomucor spp., C. bertholletiae, and A. elegans (Sun et al 2002; Kwon and Mylonakis 2007).
Negative_regulation (effective) of spp associated with sprains and strains
3) Confidence 0.41 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621380 Disease Relevance 0.89 Pain Relevance 0
In a study of 37 strains of Zygomycetes, posaconazole was effective against Mucor spp., Rhizopus spp., Absidia spp., Rhizomucor spp., C. bertholletiae, and A. elegans (Sun et al 2002; Kwon and Mylonakis 2007).
Negative_regulation (effective) of spp associated with sprains and strains
4) Confidence 0.41 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621380 Disease Relevance 0.90 Pain Relevance 0
In a study of 37 strains of Zygomycetes, posaconazole was effective against Mucor spp., Rhizopus spp., Absidia spp., Rhizomucor spp., C. bertholletiae, and A. elegans (Sun et al 2002; Kwon and Mylonakis 2007).
Negative_regulation (effective) of spp associated with sprains and strains
5) Confidence 0.41 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621380 Disease Relevance 0.90 Pain Relevance 0
Our results do suggest, however, that blockade of OPN might be useful as a therapeutic approach to inhibit invasion and metastasis of pancreatic cancer cells.
Negative_regulation (blockade) of OPN associated with pancreatic cancer and metastasis
6) Confidence 0.38 Published 2005 Journal Cancer Biol. Ther. Section Abstract Doc Link 15970685 Disease Relevance 1.38 Pain Relevance 0.35
OPN levels were significantly reduced in five SiRNA clones (C1–C5) as compared with scrambled RNA constructs and vector (pSilencer 4.1-CMV neo vector)-transfected cells.
Negative_regulation (reduced) of OPN associated with cytomegalovirus infection
7) Confidence 0.35 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.34 Pain Relevance 0
The inhibition of osteoblast maturation by the glucocorticoid was found both in osteoblast precursors (reduced osteopontin) and in more mature osteoblasts (reduced collagen type I).
Negative_regulation (reduced) of osteopontin in osteoblast associated with osteoporosis
8) Confidence 0.34 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.92 Pain Relevance 0.06
A decrease in the level of RANKL in PC3/OPN (RGA) as compared with PC3/OPN cells suggests that ?
Negative_regulation (decrease) of OPN
9) Confidence 0.30 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.02 Pain Relevance 0.08
Further, loss of OXPHOS genes SLC25A5, ATP6V1B1, B3, V0A4, and NDUFA4 may contribute to the self-sufficiency of the cancer cells with the ability to be less dependent on OXPHOS (2) The loss of tumor suppressor genes PTPRO, TFAP2A, CDKN1C, AIM1 and MT1G as well as other genes that were shown to suppress tumor growth in cancer cell lines but not yet identified as tumor suppressor candidates (RASD1, VDR, EHF, SPP1, ACPP, MT1F and ERBB4) contributes to insensitivity to antigrowth signals; (3) Evasion of apoptosis is mediated through loss of SPP1 and SFRP1, and activation of TUBB, NOL3 and EGLN3. (4) Two groups of genes are likely to be involved in tissue invasion and metastasis: proteolysis genes (PAPPA, PSMB9 and MARCH-1) and genes involved in cell-adhesion and/or regulation of actin cytoskeleton (CNGLN, ITPR2, NPHS1, ITGB2, CLD1, ZAK, WASF2, CD81) and (5) Angiogenesis may be mediated through ALDOA enzyme which is shown to be activated by HIF1 under hypoxic conditions and by increased glycolytic activity (Warburg effect), and which in a feedback loop activates HIF1 (Lu et al. 2002) which then activates several angiogenic factors including VEGF.
Negative_regulation (loss) of SPP1 associated with hypoxia, cancer, apoptosis, adhesions and metastasis
10) Confidence 0.29 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.41 Pain Relevance 0
To reduce endogenous OPN in PC3 cells, we generated four different OPN SiRNA constructs in the pSilencer vector (lanes 6–9).
Negative_regulation (reduce) of OPN
11) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.28 Pain Relevance 0.04
MMP-9 activity is significantly reduced in PC3/OPN (RGA) (B, lanes 7–10) although these individual clones express maximum levels of mutated OPN as shown in Figure 1A (lane 5).
Negative_regulation (reduced) of OPN
12) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.36 Pain Relevance 0.04
PC3 clones that express the highest levels of OPN (full length and mutant) and a maximum reduction in the endogenous levels of OPN were used for all the experiments described here.
Negative_regulation (reduction) of OPN
13) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.07 Pain Relevance 0
It appears that the reduced cellular level of OPN itself has an inhibitory effect comparable to that of bisphosphonate.
Negative_regulation (reduced) of OPN
14) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
Treatment with bortezomib resulted in a fivefold increase in levels of osteopontin while treatment with the glucocorticoid caused a strong reduction of osteopontin (Fig. 4D).
Negative_regulation (reduction) of osteopontin
15) Confidence 0.25 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.69 Pain Relevance 0
Deficiency of osteopontin or CD44 receptor also protect transgenic melatonin-deficient C57Bl/6J mice from scoliosis [19,20].
Negative_regulation (Deficiency) of osteopontin associated with scoliosis and targeted disruption
16) Confidence 0.12 Published 2009 Journal Scoliosis Section Body Doc Link PMC2781798 Disease Relevance 1.20 Pain Relevance 0

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