INT127978

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 58
Total Number 65
Disease Relevance 3.11
Pain Relevance 10.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 10
striatum 4
dorsal 3
nucleus accumbens 3
neurons 3
Trpc5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 864 99.98 Very High Very High Very High
Nucleus accumbens 216 99.98 Very High Very High Very High
Somatosensory cortex 216 99.88 Very High Very High Very High
TRP channel 822 99.86 Very High Very High Very High
Substantia nigra 57 99.68 Very High Very High Very High
Pyramidal cell 396 99.04 Very High Very High Very High
addiction 35 98.90 Very High Very High Very High
agonist 91 97.12 Very High Very High Very High
Mechanotransduction 1 96.20 Very High Very High Very High
Anterior cingulate 108 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 216 99.68 Very High Very High Very High
Targeted Disruption 137 98.06 Very High Very High Very High
Kidney Stones 16 97.40 Very High Very High Very High
Acidosis 2 91.72 High High
Death 55 76.36 Quite High
Cv Unclassified Under Development 1 69.72 Quite High
INFLAMMATION 1 69.28 Quite High
Hypersensitivity 72 53.24 Quite High
Pain 2 52.48 Quite High
Depression 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, very low expression of TRPC4 mRNA is seen in either the dorsal striatum or nucleus accumbens, which matches the real-time PCR data indicating low expression of TRPC4 and 5 mRNA in the striatum relative to whole brain TRPC4 and 5 levels (Figure 6).
Gene_expression (expression) of TRPC4 and 5 mRNA in striatum associated with nucleus accumbens
1) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0.19 Pain Relevance 0.34
TRPC5 protein is most highly expressed in the PFC and moderately expressed in the LS with lower expression in the striatum (Figure 7).
Gene_expression (expressed) of TRPC5 protein in striatum
2) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.09
Also, previous studies by von Bohlen et al. (2006) show TRPC5 protein expression in the substantia nigra using immunohistochemistry, however, our studies show a lack of TRPC5 mRNA expression in this region [28].
Gene_expression (expression) of TRPC5 protein in substantia nigra associated with substantia nigra
3) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.20
These results are consistent with previous immunohistochemical work by Chung et al. showing high expression of TRPC5 in the cell body layer of the HIP [22].
Gene_expression (expression) of TRPC5 in cell body associated with hippocampus
4) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.30
This work in cell culture systems is consistent with our finding of increased developmental expression of TRPC5 in HIP, PFC, SUB, and entorhinal cortex.
Gene_expression (expression) of TRPC5 in cortex associated with hippocampus
5) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.27
TRPC5 mRNA expression was concentrated specifically in the deep layers 5/6 and superficial layers 2/3 of the PFC and anterior cingulate.
Gene_expression (expression) of TRPC5 mRNA in PFC associated with anterior cingulate
6) Confidence 0.67 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1892805 Disease Relevance 0.17 Pain Relevance 0.45
The cell body layer of the HIP had robust expression of TRPC5 in CA1, CA2, CA3, and hilus, and moderate expression in the DG and the vSUB (Figure 5).
Gene_expression (expression) of TRPC5 in hilus associated with hippocampus
7) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0.05 Pain Relevance 0.30
TRPC5 protein is most highly expressed in the PFC and moderately expressed in the LS with lower expression in the striatum (Figure 7).
Gene_expression (expressed) of TRPC5 protein in striatum
8) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.06
Also, previous studies by von Bohlen et al. (2006) show TRPC5 protein expression in the substantia nigra using immunohistochemistry, however, our studies show a lack of TRPC5 mRNA expression in this region [28].
Gene_expression (expression) of TRPC5 mRNA in substantia nigra associated with substantia nigra
9) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.25
In subcortical structures high TRPC5 mRNA expression was detected in the Islands of Caleja, paraventricular hypothalamus, and dorsal and ventral hypothalamus.
Gene_expression (expression) of TRPC5 mRNA in hypothalamus
10) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.30
As with TRPC4, no significant TRPC5 expression was detected in layer 1 of the PFC where there are few neuronal cell bodies.
Gene_expression (expression) of TRPC5 in neuronal
11) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0.11 Pain Relevance 0.38
HIP TRPC5 protein is present at low levels from embryonic day 18 (E18) E18 to P20 and increase robustly from P20 to P48 (Figure 8B).
Gene_expression (present) of TRPC5 protein in P48 associated with hippocampus
12) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.14
Little expression of TRPC5 is seen in the MCx, SCx and no expression is seen in the dorsal striatum although, interestingly, moderate expression of TRPC5 was detected in the nucleus accumbens (Figure 3, Table 2).


Gene_expression (expression) of TRPC5 in dorsal associated with nucleus accumbens and somatosensory cortex
13) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.24
To examine the surface expression of TRPC5 protein in P0 and P48 day old mice, we used the irreversible, membrane impermeable crosslinker, BS3 to cross-link surface-expressed TRPC proteins.
Spec (examine) Gene_expression (expression) of TRPC5 protein in P48
14) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.13
In situ hybridization histochemistry and immunoblotting further resolved a dense corticolimbic expression of the TRPC4 and TRPC5 channels.
Gene_expression (expression) of TRPC5
15) Confidence 0.67 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1892805 Disease Relevance 0.16 Pain Relevance 0.21
Little expression of TRPC5 is seen in the MCx, SCx and no expression is seen in the dorsal striatum although, interestingly, moderate expression of TRPC5 was detected in the nucleus accumbens (Figure 3, Table 2).


Gene_expression (expression) of TRPC5 in dorsal associated with nucleus accumbens and somatosensory cortex
16) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.27
Region-specific protein expression of TRPC4 and TRPC5
Gene_expression (expression) of TRPC5
17) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.03
However, a more likely explanation for our results in the nucleus accumbens is a differential pre vs. postsynaptic expression of the TRPC5 mRNA and protein.
Gene_expression (expression) of TRPC5 mRNA in nucleus accumbens associated with nucleus accumbens
18) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.25
The qualitative expression of TRPC4 and 5 mRNA throughout the rat and mouse brain is presented in Table 2.
Gene_expression (expression) of TRPC4 and 5 mRNA in brain
19) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0.07 Pain Relevance 0.12
TRPC5 was highly expressed in the frontal cortex, pyramidal cell layer of the HIP, DG, and hypothalamus.
Gene_expression (expressed) of TRPC5 in hypothalamus associated with pyramidal cell, urological neuroanatomy and hippocampus
20) Confidence 0.67 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1892805 Disease Relevance 0.19 Pain Relevance 0.41

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