INT127981

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 25
Total Number 31
Disease Relevance 10.51
Pain Relevance 11.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpc1) protein complex (Trpc1) transmembrane transport (Trpc1)
cytoplasm (Trpc1)
Anatomy Link Frequency
neurons 6
neuronal 3
dorsal root ganglion 3
IB4 2
substantia nigra 2
Trpc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
TRP channel 340 100.00 Very High Very High Very High
dorsal root ganglion 159 100.00 Very High Very High Very High
tetrodotoxin 63 100.00 Very High Very High Very High
Calcitonin gene-related peptide 39 100.00 Very High Very High Very High
Pain 29 100.00 Very High Very High Very High
nociceptor 10 100.00 Very High Very High Very High
withdrawal 4 100.00 Very High Very High Very High
substance P 72 99.76 Very High Very High Very High
unmyelinated 5 99.74 Very High Very High Very High
Substantia nigra 41 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 177 100.00 Very High Very High Very High
Nociception 31 100.00 Very High Very High Very High
Melanoma 3 99.76 Very High Very High Very High
Aggression 1 99.12 Very High Very High Very High
INFLAMMATION 89 98.96 Very High Very High Very High
Hypersensitivity 19 98.40 Very High Very High Very High
Dyspepsia 41 98.12 Very High Very High Very High
Cancer 9 97.92 Very High Very High Very High
Diabetes Mellitus 11 97.76 Very High Very High Very High
Pain 32 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study demonstrates, for the first time, a coexpression of TRPC1 and mGluR1 receptors in dendrites of the substantia nigra dopaminergic neurons.
Gene_expression (coexpression) of TRPC1 in substantia nigra associated with substantia nigra
1) Confidence 0.77 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16930403 Disease Relevance 0 Pain Relevance 0.49
Single-label immunohistochemistry and double-label immunofluorescence were used to study the expression of TRPC1 among substantia nigra dopamine neurons and cellular processes using antibodies against tyrosine hydroxylase (TH), substance P (SP), enkephalin, synaptophysin, vesicular glutamate transporter-2 (Vglut-2), microtubule associated protein-2 and metabotropic glutamate receptor 1 (mGluR1).
Gene_expression (expression) of TRPC1 in substantia nigra associated with glutamate, dopamine, glutamate receptor, substantia nigra, enkephalin and substance p
2) Confidence 0.77 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16930403 Disease Relevance 0 Pain Relevance 0.53
The aim of the present study was to characterize the expression of TRPC1, at a protein level, in the substantia nigra neurons and non-excitable cells of Wistar rats.
Gene_expression (expression) of TRPC1 in neurons associated with substantia nigra
3) Confidence 0.77 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16930403 Disease Relevance 0 Pain Relevance 0.44
Terminals arising from unmyelinated fibers also expressed TRPC1 and TRPC3-5 but not all fibers expressed all of the channels suggesting that specific TRPC protein may be aligned with previously described subclasses of the unmyelinated C-fibers.
Gene_expression (expressed) of TRPC1 associated with c fibre and unmyelinated
4) Confidence 0.73 Published 2005 Journal Pflugers Arch. Section Abstract Doc Link 15971079 Disease Relevance 0 Pain Relevance 0.24
Distribution of TRPC1 receptors in dendrites of rat substantia nigra: a confocal and electron microscopy study.
Gene_expression (Distribution) of TRPC1 in dendrites associated with substantia nigra
5) Confidence 0.67 Published 2006 Journal Eur. J. Neurosci. Section Title Doc Link 16930403 Disease Relevance 0 Pain Relevance 0.42
A set of dual label experiments was also performed to investigate the presence of TRPC1 among glial cells.
Spec (investigate) Gene_expression (presence) of TRPC1 in glial cells
6) Confidence 0.60 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16930403 Disease Relevance 0 Pain Relevance 0.55
Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn.
Gene_expression (Expression) of transient receptor potential ankyrin 1 in spinal associated with nociceptor and spinal dorsal horn
7) Confidence 0.47 Published 2010 Journal J. Comp. Neurol. Section Title Doc Link 20034057 Disease Relevance 0.42 Pain Relevance 0.79
TRPC5 was expressed in the dissociated cells of the entire telencephalon and in the neural progenitor subpopulation but not in NSCs, which expressed TRPC1–4 and 6 [13].
Gene_expression (expressed) of TRPC1 in neural
8) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.07 Pain Relevance 0.12
They also reported that strong expression of TRPC-1 as well as TRPC2, 3, 4 and TRPC6 with barely expressed TRPC5 and TRPC7 as shown in the sort purified A2B5+ NPC harvested from postnatal-12-day rat cerebrum in this study (Figure S3).
Gene_expression (expression) of TRPC-1 in cerebrum associated with trp channel
9) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0 Pain Relevance 0.08
In this study, we investigated the hippocampal TRPV1 (transient receptor potential vanilloid 1) expression in ovariectomized rats that received 17-beta-estradiol substitution and found that 17-beta-estradiol enhanced the mechanical allodynia of inflamed temporomandibular joint (TMJ) induced by complete Freund's adjuvant.
Spec (investigated) Gene_expression (expression) of transient receptor potential vanilloid 1 in TMJ associated with snapping jaw and allodynia
10) Confidence 0.41 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592193 Disease Relevance 1.23 Pain Relevance 1.17
As canonical transient receptor channels (TRPCs) are known to form NSCCs, we looked for TRPCs subunits using single-cell RT-PCR and found that TRPC6 mRNA was detectable in a small minority, TRPC1, TRPC3 and TRPC7 in a majority and TRPC4 and 5 in the vast majority (?
Gene_expression (detectable) of TRPC1
11) Confidence 0.40 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3002943 Disease Relevance 0 Pain Relevance 0.09
Our results however differ from those in SNr neurons as TRPC5 subunits are implicated here and, in addition, the current described in the present study has a strong voltage-dependence, not very different from the one seen in HEK cells co-transfected with TRPC1 and TRPC5 cDNAs [19].
Gene_expression (transfected) of TRPC1 in neurons associated with addiction
12) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002943 Disease Relevance 0 Pain Relevance 0.22
The main pattern was characterized by the presence of TRPC1, 3, 4, 5 and 7 (illustrated on Fig. 2B) and was found in 12 (out of 41) hcrt/orx neurons (* in Fig. 2C), whereas other patterns (Fig. 2C) were found less frequently, some of them being present in only one cell.
Gene_expression (presence) of TRPC1 in neurons
13) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002943 Disease Relevance 0 Pain Relevance 0.03
TRPC3, TRPC1, and TRPC6 are moderately expressed at 18%, 12%, and 5% of the population respectively.
Gene_expression (expressed) of TRPC1
14) Confidence 0.38 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0
References and validation (based on physiology, western blotting, immunohistochemistry, antisense and siRNA approaches) for the Alomone antibodies used in the present study (i.e. for TRPC1, 3, 4 and 5) can be found in the following papers: for TRPC1 [31]–[36]; for TRPC3 [18], [26], [35], [37], [38]; for TRPC4 [34]–[36], [39]; for TRPC5 [31], [35], [39]–[41].
Gene_expression (found) of TRPC1
15) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002943 Disease Relevance 0 Pain Relevance 0
Table 1 demonstrates that the gene expression of TRPC1 and TRPC4 were down-regulated in the differentiated neuronal cells compared to A2B5+ NPCs.
Gene_expression (expression) of TRPC1 in neuronal
16) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.08 Pain Relevance 0.13
In this study, it is demonstrated that the neuronal differentiation of A2B5+ NPCs was closely associated with the change of the up-regulated expression of TRPC5 and 6 combined with down-regulated expression of TRPC1 as SOCE channel (Table 1).
Gene_expression (expression) of TRPC1 in neuronal
17) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.08 Pain Relevance 0.04
In the previous study, all five TRPC proteins (TRPC1, 3, 4, 5, 6) detected were more highly expressed in the embryonic CNS compared with the adult, suggesting TRPC channels as candidates for mediating Ca2+ entry during proliferation of neuroepithelial cells [10].
Gene_expression (expressed) of TRPC1 in neuroepithelial cells associated with trp channel
18) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.23 Pain Relevance 0.14
A2B5+ NPCs also expressed TRPC1 to 7, but TRPC2, a known pseudo gene (Figure S3).
Gene_expression (expressed) of TRPC1
19) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.09 Pain Relevance 0.14
All five TRPC proteins (TRPC1, 3, 4, 5, 6) detected were more highly expressed in the embryonic CNS compared with the adult, suggesting TRPC channels as candidates for mediating Ca2+ entry during proliferation of neuroepithelial cells [10].
Gene_expression (expressed) of TRPC1 in neuroepithelial cells associated with trp channel
20) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0 Pain Relevance 0.56

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