INT127984

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.74
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LRP1) endosome (LRP1) aging (LRP1)
plasma membrane (LRP1) nucleus (LRP1) cytoplasm (LRP1)
Anatomy Link Frequency
THP-1 2
hind limbs 1
LRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4 88.32 High High
qutenza 2 81.92 Quite High
anesthesia 2 71.92 Quite High
Pain 4 22.40 Low Low
cytokine 28 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 88.32 High High
Reprotox - General 1 43 87.36 High High
Disorder Of Lipid Metabolism 34 77.12 Quite High
Disease 5 63.80 Quite High
Body Weight 2 59.92 Quite High
Diabetes Mellitus 2 32.40 Quite Low
Fever 3 28.32 Quite Low
Increased Venous Pressure Under Development 1 24.40 Low Low
Pain 4 22.40 Low Low
Targeted Disruption 4 14.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only histamine increased the mucosal output of alpha(2)-macroglobulin (P<0.01).
Positive_regulation (increased) of macroglobulin
1) Confidence 0.69 Published 2005 Journal Clin Physiol Funct Imaging Section Abstract Doc Link 15972027 Disease Relevance 0.22 Pain Relevance 0.16
g cholesterol/ml) for 24 h, LRP mRNA levels were increased in CRLP- treated THP-1 cells (fold change, 2.7 ± 1.01, n = 3), while LDLr mRNA abundance was decreased (0.27 ± 0.11(range), n = 2).


Positive_regulation (increased) of LRP in THP-1
2) Confidence 0.13 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC1906864 Disease Relevance 0.20 Pain Relevance 0
We have shown previously that the expression of mRNA for the LDLr in THP-1 macrophages is decreased by CRLPs while the expression of LRP mRNA is increased [18], and the present study, which shows a decrease of about 73% in LDLr mRNA and a 2.7fold rise in LRP mRNA after exposure of the macrophages to CRLPs, is in agreement with these findings.
Positive_regulation (rise) of LRP in THP-1
3) Confidence 0.13 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC1906864 Disease Relevance 0 Pain Relevance 0
In other words, we included patients who underwent RPP, RRP, LRP, RLRP, and HIFU.
Positive_regulation (underwent) of LRP
4) Confidence 0.02 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2941808 Disease Relevance 0.20 Pain Relevance 0
Induction of APR
Positive_regulation (Induction) of APR
5) Confidence 0.02 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.06 Pain Relevance 0.07
APR was induced in ether-anesthetized rats by intramuscular injection of 5 mg/kg turpentine oil (TO) into both the right and left hind limbs of the animals.
Positive_regulation (induced) of APR in hind limbs
6) Confidence 0.02 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.06 Pain Relevance 0.07

General Comments

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