INT127987

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.60
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EPO) extracellular space (EPO) aging (EPO)
extracellular region (EPO)
Anatomy Link Frequency
red blood cell 2
EPO (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 4 100.00 Very High Very High Very High
cytokine 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myelodysplastic Syndromes 21 98.76 Very High Very High Very High
Hypersensitivity 5 87.80 High High
Hyperplasia 1 84.52 Quite High
Erythrocytosis 11 50.00 Quite Low
Hypoxia 93 36.12 Quite Low
Fatigue 4 5.00 Very Low Very Low Very Low
Headache 3 5.00 Very Low Very Low Very Low
Stroke 3 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Effect of recombinant human G-CSF combined with EPO in treatment of patients with MDS].
Regulation ([Effect) of EPO Binding (combined) of associated with myelodysplastic syndromes and headache
1) Confidence 0.45 Published 2005 Journal Zhongguo Shi Yan Xue Ye Xue Za Zhi Section Title Doc Link 15972155 Disease Relevance 0.43 Pain Relevance 0.10
In addition, the mechanism is in accord with a recent investigation demonstrating that phosphorylated Y429, Y431, and Y479 in the EPOR cytoplasmic domain bind the p85 subunit of PI3 kinase on EPO stimulation and individually are involved in mediating EPO-dependent EPOR internalization [36].
Regulation (mediating) of EPO-dependent Binding (internalization) of
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.17 Pain Relevance 0
Our rhEpo treatment, which aimed to mimic what could be a procedure of rhEpo misuse, was shown to increase red blood cell volume substantially (?
Regulation (Our) of rhEpo Binding (treatment) of in red blood cell
3) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500186 Disease Relevance 0 Pain Relevance 0

General Comments

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