INT127987

Context Info Confidence 0.45 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.60 Pain Relevance 0.10

signal transduction (EPO) extracellular space (EPO) aging (EPO) extracellular region (EPO)

Anatomy Link Frequency red blood cell 2 EPO (Homo sapiens)

Pain Link Frequency Relevance Heat headache 4 100.00 cytokine 4 5.00 anesthesia 2 5.00 Central nervous system 1 5.00 ischemia 1 5.00 Glutamate 1 5.00

Disease Link Frequency Relevance Heat Myelodysplastic Syndromes 21 98.76 Hypersensitivity 5 87.80 Hyperplasia 1 84.52 Erythrocytosis 11 50.00 Hypoxia 93 36.12 Fatigue 4 5.00 Headache 3 5.00 Stroke 3 5.00 Peripheral Arterial Disease 2 5.00 Targeted Disruption 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

[Effect of recombinant human G-CSF combined with EPO in treatment of patients with MDS].

Regulation ([Effect) of EPO Binding (combined) of associated with myelodysplastic syndromes and headache

1) Confidence 0.45 Published 2005 Journal Zhongguo Shi Yan Xue Ye Xue Za Zhi Section Title Doc Link 15972155 Disease Relevance 0.43 Pain Relevance 0.10

In addition, the mechanism is in accord with a recent investigation demonstrating that phosphorylated Y429, Y431, and Y479 in the EPOR cytoplasmic domain bind the p85 subunit of PI3 kinase on EPO stimulation and individually are involved in mediating EPO-dependent EPOR internalization [36].

Regulation (mediating) of EPO-dependent Binding (internalization) of

2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.17 Pain Relevance 0

Our rhEpo treatment, which aimed to mimic what could be a procedure of rhEpo misuse, was shown to increase red blood cell volume substantially (?

Regulation (Our) of rhEpo Binding (treatment) of in red blood cell

3) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500186 Disease Relevance 0 Pain Relevance 0

General Comments

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