INT127997

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.41
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (MC1R) plasma membrane (MC1R) signal transducer activity (MC1R)
Anatomy Link Frequency
skin 1
MC1R (Homo sapiens)
RHCE (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 159 100.00 Very High Very High Very High
addiction 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 154 90.48 High High
Skin Cancer 6 75.00 Quite High
Disease 5 50.96 Quite High
Nevus 31 29.76 Quite Low
Sunburn 14 5.00 Very Low Very Low Very Low
Cancer 11 5.00 Very Low Very Low Very Low
Burns 7 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Retinoblastoma 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that reduced receptor coupling activity may not be the only contributing factor to the genetic association between the MC1R variants and the RHC phenotype, with MC1R polymorphisms now linked to a change in receptor localization.
MC1R Binding (association) of RHC
1) Confidence 0.28 Published 2005 Journal Hum. Mol. Genet. Section Abstract Doc Link 15972726 Disease Relevance 0.13 Pain Relevance 0
The RHC variants included four MC1R variants (R151C, R160W, D294H, and D84E), which have been consistently reported to be associated with RHC and light skin color; all other nonsynonymous variants were coded as NRHC.
MC1R Binding (associated) of RHC in skin associated with melanocortin 1 receptor
2) Confidence 0.07 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.29 Pain Relevance 1.02

General Comments

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