INT128

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Context Info
Confidence 0.59
First Reported 1976
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.92
Pain Relevance 2.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OXTR) signal transducer activity (OXTR)
Anatomy Link Frequency
uterus 2
brain 2
uterine 2
OXTR (Homo sapiens)
Pain Link Frequency Relevance Heat
epidural 9 100.00 Very High Very High Very High
pain labor 4 100.00 Very High Very High Very High
Endogenous opioid 4 99.98 Very High Very High Very High
opioid receptor 1 99.56 Very High Very High Very High
local anesthetic 4 99.52 Very High Very High Very High
Opioid 4 99.44 Very High Very High Very High
intrathecal 8 99.30 Very High Very High Very High
Catecholamine 2 99.16 Very High Very High Very High
cINOD 1 98.88 Very High Very High Very High
Dismenorea 1 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Labor Pain 4 100.00 Very High Very High Very High
INFLAMMATION 39 98.68 Very High Very High Very High
Hypoglycemia 5 97.88 Very High Very High Very High
Dysmenorrhea 1 97.40 Very High Very High Very High
Disease 32 96.76 Very High Very High Very High
Stress 48 95.72 Very High Very High Very High
Staphylococcus Infection 28 82.28 Quite High
Breast Disease 10 50.00 Quite Low
Bovine Mastitis 4 17.56 Low Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence from oxytocin receptor blockade and suppression of oxytocin secretion supports the concept that oxytocin is an important stimulus for uterine contractions in early human labor.
Negative_regulation (suppression) of Localization (secretion) of oxytocin in uterine associated with dismenorea
1) Confidence 0.59 Published 1989 Journal Am J Perinatol Section Abstract Doc Link 2540759 Disease Relevance 0.10 Pain Relevance 0.10
Both epidural local anesthetics and intrathecal opioid reduce some parameters of the neuroendocrine response to labor pain and the reflex release of oxytocin in animals.
Negative_regulation (reduce) of Localization (release) of oxytocin associated with epidural, pain labor, opioid and intrathecal
2) Confidence 0.58 Published 2001 Journal Reg Anesth Pain Med Section Abstract Doc Link 11707794 Disease Relevance 0.10 Pain Relevance 0.94
This permits the identification of four possible points of attack: (1) replacement of progesterone to reduce the myometrial sensitivity to oxytocin, (2) administration of beta-mimetic agents to relax the uterus and make it unresponsive to stimuli, (3) administration of ethanol to block oxytocin secretion, and (4) administration of anti-inflammatory drugs to inhibit prostaglandin synthesis.
Negative_regulation (block) of Localization (secretion) of oxytocin in uterus associated with inflammation and cinod
3) Confidence 0.58 Published 1976 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 11689 Disease Relevance 0.10 Pain Relevance 0.10
Although ineffective when given alone, opioids potentiate the release of oxytocin in the limbic brain and increase the intensity of maternal responding, while the opioid receptor blocker, naltrexone, prevents both maternal induction and oxytocin release.
Negative_regulation (prevents) of Localization (release) of oxytocin in brain associated with opioid receptor and opioid
4) Confidence 0.53 Published 1994 Journal Acta Paediatr Suppl Section Abstract Doc Link 7981474 Disease Relevance 0 Pain Relevance 0.19
In humans, epidural local anesthetics only reduce the spurt release of oxytocin.
Negative_regulation (reduce) of Localization (release) of oxytocin
5) Confidence 0.51 Published 2001 Journal Reg Anesth Pain Med Section Abstract Doc Link 11707794 Disease Relevance 0.10 Pain Relevance 0.92
In men, endogenous opioids inhibit the release of oxytocin when AVP secretion is stimulated by insulin-induced hypoglycemia.
Negative_regulation (inhibit) of Localization (release) of oxytocin associated with hypoglycemia and endogenous opioid
6) Confidence 0.44 Published 1990 Journal Acta Endocrinol. Section Abstract Doc Link 2185602 Disease Relevance 0.31 Pain Relevance 0.40
The release of oxytocin in response to stressful stimuli may reduce
Spec (may) Negative_regulation (reduce) of Localization (release) of oxytocin
7) Confidence 0.06 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2324165 Disease Relevance 1.10 Pain Relevance 0.11
stressed mothers impairs the release and access of oxytocin to the mammary
Negative_regulation (impairs) of Localization (release) of oxytocin
8) Confidence 0.06 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2324165 Disease Relevance 1.11 Pain Relevance 0.11

General Comments

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