INT1280

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Context Info
Confidence 0.28
First Reported 1976
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.12
Pain Relevance 6.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Pebp1) mitochondrion (Pebp1) extracellular space (Pebp1)
aging (Pebp1) Golgi apparatus (Pebp1) response to stress (Pebp1)
Anatomy Link Frequency
dorsal 1
Pebp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 53 100.00 Very High Very High Very High
Bradyzide 10 100.00 Very High Very High Very High
monoamine 1 100.00 Very High Very High Very High
narcan 8 99.84 Very High Very High Very High
Analgesic 12 98.36 Very High Very High Very High
Opioid 1 94.52 High High
Antihyperalgesic 2 93.92 High High
Hyperalgesia 6 93.24 High High
Pain 2 91.60 High High
Inflammation 10 89.04 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 10 99.84 Very High Very High Very High
Hyperalgesia 10 99.00 Very High Very High Very High
Pain 2 91.60 High High
INFLAMMATION 8 89.04 High High
Learning Disorders 1 43.92 Quite Low
Dementia 1 42.32 Quite Low
Neurological Disease 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pregnancy decreased estrone and morphine glucuronyltransferase activity 20%, whereas E2 treatment increased activity 50%.
Negative_regulation (decreased) of morphine glucuronyltransferase associated with morphine
1) Confidence 0.28 Published 1982 Journal Drug Metab. Dispos. Section Abstract Doc Link 6126331 Disease Relevance 0 Pain Relevance 0.62
Similarity search has revealed that PEBP might be a serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase.
Negative_regulation (inhibitor) of PEBP
2) Confidence 0.16 Published 2003 Journal Proteome Sci Section Body Doc Link PMC165415 Disease Relevance 0 Pain Relevance 0.13
Both the effects of AcS-morphine were inhibited by naloxone, suggesting that the site of action of AcS-morphine is mu-receptors.
Negative_regulation (inhibited) of AcS-morphine associated with narcan and morphine
3) Confidence 0.13 Published 1988 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 3069065 Disease Relevance 0 Pain Relevance 1.63
Marker enzymes used to evaluate the subcellular fractions included cytochrome oxidase, monoamine oxidase, D-amino acid oxidase, acid phosphatase, glucose-6-phosphatase, ethyl morphine demethylase, and lactate dehydrogenase.
Negative_regulation (evaluate) of ethyl morphine demethylase associated with morphine and monoamine
4) Confidence 0.05 Published 1976 Journal Prep. Biochem. Section Abstract Doc Link 184448 Disease Relevance 0 Pain Relevance 0.15
Both the effects of AcS-morphine were inhibited by naloxone, suggesting that the site of action of AcS-morphine is mu-receptors. 3.
Negative_regulation (inhibited) of AcS-morphine associated with narcan and morphine
5) Confidence 0.05 Published 1990 Journal Gen. Pharmacol. Section Abstract Doc Link 2177430 Disease Relevance 0 Pain Relevance 1.20
The inhibitory effect of bradyzide and morphine on oedema formation and hyperalgesic response was compared with that of cyproheptadine (CPH), a potent inhibitor of DL-induced oedema formation. 4 The hyperalgesic response was evaluated by the dorsal flexion pain test, compression test and by observing motility, stair-climbing ability, and the grooming behaviour of the rats. 5 The effect of these drugs was also evaluated against DL-induced writhings in the mouse model. 6 Both bradyzide and morphine inhibited DL-induced oedema formation by 30-40% and CPH was more effective in this regard (81% inhibition).
Negative_regulation (effect) of morphine in dorsal associated with pain, hyperalgesia, pressure and volume under development, bradyzide and morphine
6) Confidence 0.02 Published 2007 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 17584444 Disease Relevance 1.14 Pain Relevance 1.26
Both bradyzide and morphine markedly inhibited the grooming behaviour and the effect of morphine could be reversed by pretreatment with naloxone. 7 Thus, our study shows that DL-induced oedema formation is effectively inhibited by antihistaminic/antiserotonergic drug and associated hyperalgesia by analgesic drugs.
Negative_regulation (reversed) of morphine associated with pressure and volume under development, hyperalgesia, analgesic, narcan, bradyzide and morphine
7) Confidence 0.02 Published 2007 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 17584444 Disease Relevance 0.98 Pain Relevance 1.46

General Comments

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