INT128000

Context Info Confidence 0.75 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 11 Disease Relevance 1.39 Pain Relevance 1.18

Anatomy Link Frequency plasma 1 thyroid 1 hair 1 skin 1 molar 1 RHCE (Homo sapiens)

Pain Link Frequency Relevance Heat melanocortin 1 receptor 11 100.00 Bioavailability 27 98.26 agonist 22 93.32 Clonidine 8 52.52 Pain 12 5.00 tolerance 8 5.00 Somatostatin 3 5.00

Disease Link Frequency Relevance Heat Skin Cancer 6 96.40 Disease 3 91.68 Sprains And Strains 4 91.44 Thyroid Disease 84 89.68 Syndrome 3 88.88 Chronic Disease 3 85.16 Appetite Loss 3 83.92 Liver Disease 3 83.36 Malabsorption Syndromes 3 82.72 Hypopituitarism 3 59.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results highlight the use of the coculture system in determining fundamental differences in the physiology of melanocytes expressing RHC MC1R receptors and those of WT genotype, which are likely to contribute to the increased skin cancer risk for individuals that carry these variants.

Gene_expression (expressing) of RHC in skin associated with melanocortin 1 receptor and skin cancer

1) Confidence 0.75 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 17960564 Disease Relevance 0.32 Pain Relevance 0.39

We have established a serum free human melanocyte-keratinocyte coculture system to study the behavior and functional abilities of melanocytes expressing MC1R red hair color (RHC) variants in order to identify differences from their wild type (WT) counterparts.

Gene_expression (expressing) of RHC in hair associated with melanocortin 1 receptor

2) Confidence 0.75 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 17960564 Disease Relevance 0.15 Pain Relevance 0.39

The V60L, V92M and R163Q weakly associated RHC alleles, designated 'r', were expressed with normal or intermediate cell surface receptor levels.

Gene_expression (expressed) of RHC

3) Confidence 0.71 Published 2005 Journal Hum. Mol. Genet. Section Abstract Doc Link 15972726 Disease Relevance 0.13 Pain Relevance 0

The volume of distribution was around 3 L in both groups, indicating that the rhFSH was generally distributed in plasma.

Gene_expression (distributed) of rhFSH in plasma

4) Confidence 0.07 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0.11

In fact at 48 hours after rhFSH injections, 10 out of 12 cases in abdominal injection group surpassed the FSH threshold while only 3 out of 12 cases in vaginal injection group had serum FSH concentration over the FSH threshold of 7.8 IU/L (Figure 4).

Gene_expression (injections) of rhFSH

5) Confidence 0.07 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0

This fact might explain a higher E2 level found around 48-72 hours in those of abdominal injections even though in general the rhFSH absorption was higher in those of vaginal injections.

Gene_expression (absorption) of rhFSH

6) Confidence 0.07 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0

Compared to previous similar studies using a single 300 IU rhFSH injection, the extent of absorption revealed by the AUC0-?

Gene_expression (injection) of rhFSH

7) Confidence 0.07 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0.16

The aim of current study was to evaluate the effect of rhGH substitution on TSH and FT4 serum concentrations in children with GHD during the 1st year of therapy, as well as to assess potential indications to thyroid hormone supplementation in them.

Gene_expression (substitution) of rhGH in thyroid

8) Confidence 0.06 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.21 Pain Relevance 0

The obtained results of that test supported the indications to rhGH administration in them.

Gene_expression (administration) of rhGH

9) Confidence 0.06 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.43 Pain Relevance 0.05

Statistical analysis included comparison of thyroid function (FT4 and TSH concentrations), IGF-I secretion (as IGF-I SDS) and its bioavailability (expressed as IGF-I/IGFBP-3 molar ratio) in particular time points, before and during rhGH therapy.

Gene_expression (therapy) of rhGH in molar associated with bioavailability

10) Confidence 0.06 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0 Pain Relevance 0.08

anti-rhGH was produced, conjugated to HRPO or further purified

Gene_expression (produced) of rhGH

11) Confidence 0.03 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551587 Disease Relevance 0.14 Pain Relevance 0

General Comments

This test has worked.