INT128003

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.56
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (MC1R) plasma membrane (MC1R) signal transducer activity (MC1R)
Anatomy Link Frequency
fat 2
liver 2
melanocyte 2
keratinocytes 2
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 14 100.00 Very High Very High Very High
Inflammation 7 92.76 High High
Inflammatory response 1 91.76 High High
cytokine 1 87.16 High High
Disease Link Frequency Relevance Heat
Brain Death 4 99.08 Very High Very High Very High
Obesity 4 98.96 Very High Very High Very High
INFLAMMATION 8 92.76 High High
Skin Cancer 3 82.60 Quite High
Cancer 1 78.84 Quite High
Necrosis 1 78.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduced expression of the melanocortin-1 receptor in human liver during brain death.
Negative_regulation (Reduced) of Gene_expression (expression) of melanocortin-1 receptor in liver associated with brain death and melanocortin 1 receptor
1) Confidence 0.59 Published 2006 Journal Neuroimmunomodulation Section Title Doc Link 16864968 Disease Relevance 0.64 Pain Relevance 0.36
This study was aimed at determining the quantitative expression of the five melanocortin receptors (MC1-R to MC5-R) in subcutaneous and omental fat of obese patients and non-obese subjects.
Spec (determining) Negative_regulation (determining) of Gene_expression (expression) of MC5-R in fat associated with obesity
2) Confidence 0.43 Published 2007 Journal Obesity (Silver Spring) Section Abstract Doc Link 17228030 Disease Relevance 0.36 Pain Relevance 0.07
Constitutive expression of MC1R in HaCaT keratinocytes inhibits basal and UVB-induced TNF-alpha production.
Negative_regulation (inhibits) of Gene_expression (expression) of MC1R in keratinocytes
3) Confidence 0.42 Published 2009 Journal Photochem. Photobiol. Section Title Doc Link 19656324 Disease Relevance 0.33 Pain Relevance 0.77
Using immunofluorescence and ligand binding studies, we found that melanocytic cells exogenously or endogenously expressing MC1R show strong surface localization of the wild-type and D294H alleles but markedly reduced cell surface expression of the R151C and R160W receptors.
Negative_regulation (reduced) of Gene_expression (expressing) of MC1R
4) Confidence 0.42 Published 2005 Journal Hum. Mol. Genet. Section Abstract Doc Link 15972726 Disease Relevance 0.15 Pain Relevance 0.06
However, there is an obvious lack of knowledge regarding the numerous and complex regulatory mechanisms that govern the expression of MC1R at the intra-cellular level, from gene transcription in response to an external stimulus to the expression of the mature receptor on the melanocyte surface.
Negative_regulation (govern) of Gene_expression (expression) of MC1R in melanocyte
5) Confidence 0.36 Published 2005 Journal Peptides Section Abstract Doc Link 16005546 Disease Relevance 0.08 Pain Relevance 0.14

General Comments

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