INT12801

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Context Info
Confidence 0.43
First Reported 1981
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.20
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) aging (Agt) extracellular region (Agt)
extracellular matrix organization (Agt)
Anatomy Link Frequency
ICV 2
Agt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 3 100.00 Very High Very High Very High
antagonist 11 99.98 Very High Very High Very High
Opioid 5 99.14 Very High Very High Very High
Serotonin 2 98.86 Very High Very High Very High
narcan 3 98.72 Very High Very High Very High
Pain 1 95.12 Very High Very High Very High
Intracerebroventricular 1 87.44 High High
Potency 2 87.32 High High
analgesia 1 85.72 High High
tail-flick 1 79.84 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 1 99.36 Very High Very High Very High
Hypertension 1 96.56 Very High Very High Very High
Pain 1 95.12 Very High Very High Very High
Increased Venous Pressure Under Development 5 94.96 High High
Hypoxia 1 92.32 High High
Arrhythmia Under Development 2 85.36 High High
Stress 1 75.00 Quite High
Premature Ventricular Beats 1 72.36 Quite High
Arrhythmias 2 Under Development 1 60.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mu opioids antagonist naloxone and the kappa opioid antagonist MR 2266, 50 micrograms/kg ICV, prevented the effect of Ang II on fatal arrhythmias.
Negative_regulation (prevented) of Regulation (effect) of Ang II in ICV associated with antagonist, narcan and opioid
1) Confidence 0.43 Published 1991 Journal Life Sci. Section Abstract Doc Link 1654493 Disease Relevance 0.30 Pain Relevance 0.60
Tempol blunted or prevented all these effects of ANG II.
Negative_regulation (prevented) of Regulation (effects) of ANG II
2) Confidence 0.42 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15598867 Disease Relevance 0.36 Pain Relevance 0.07
The inhibition of serotonin synthesis with PCPA--400 mg/kg/day i.p. for five days as well as the serotonin-receptor block with ketanserin 0.1 mg/kg i.p. partially prevent analgesic effects of Ang II and renin intracerebral administration.
Negative_regulation (prevent) of Regulation (effects) of Ang II associated with analgesic and serotonin
3) Confidence 0.36 Published 1983 Journal Physiologie Section Abstract Doc Link 6417696 Disease Relevance 0.10 Pain Relevance 0.83
Neither antagonist blocked the pressor responses to angiotensin II (A II) nor the tachycardia-induced by exogenous NA, indicating specificity for alpha 2-adrenoreceptors. 3 BE 2254 was a potent antagonist of TL99-induced cardioinhibition (presynaptic alpha 2-adrenoreceptor effects) in the pithed rat, but may not act as a competitive antagonist in this preparation.
Negative_regulation (blocked) of Regulation (responses) of angiotensin II associated with heart rate under development and antagonist
4) Confidence 0.31 Published 1981 Journal J Auton Pharmacol Section Abstract Doc Link 6123512 Disease Relevance 0.45 Pain Relevance 0.46

General Comments

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