INT128013

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 10.65
Pain Relevance 16.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a3)
Anatomy Link Frequency
spinal 8
dorsal horn 6
nerve 4
spinal cord 3
dorsal root ganglion 3
Slc1a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 1065 100.00 Very High Very High Very High
spinal dorsal horn 71 100.00 Very High Very High Very High
Dorsal horn 48 100.00 Very High Very High Very High
Calcitonin gene-related peptide 37 100.00 Very High Very High Very High
Antinociceptive 23 99.96 Very High Very High Very High
Pain 160 99.88 Very High Very High Very High
wide dynamic range 8 99.74 Very High Very High Very High
Spinal cord 189 99.68 Very High Very High Very High
Thermal hyperalgesia 13 99.64 Very High Very High Very High
Peripheral nerve injury 11 99.14 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 212 99.88 Very High Very High Very High
Hyperalgesia 37 99.64 Very High Very High Very High
Nociception 98 99.48 Very High Very High Very High
Nervous System Injury 64 99.14 Very High Very High Very High
Bordatella Infection 4 98.82 Very High Very High Very High
Ganglion Cysts 38 98.56 Very High Very High Very High
Neurodegenerative Disease 3 98.28 Very High Very High Very High
Hypersensitivity 37 97.16 Very High Very High Very High
Drug Induced Neurotoxicity 7 96.96 Very High Very High Very High
Injury 14 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altered discharges of spinal wide dynamic range neurons and down-regulation of glutamate transporter expression in rats with paclitaxel-induced hyperalgesia.
Negative_regulation (down-regulation) of Gene_expression (expression) of glutamate transporter in neurons associated with hyperalgesia, glutamate and wide dynamic range
1) Confidence 0.59 Published 2006 Journal Neuroscience Section Title Doc Link 16361064 Disease Relevance 0.26 Pain Relevance 0.82
The expression of glutamate transporter proteins in the dorsal horn is decreased at the time point corresponding to the physiological changes.
Negative_regulation (decreased) of Gene_expression (expression) of glutamate transporter in dorsal horn associated with glutamate and dorsal horn
2) Confidence 0.59 Published 2006 Journal Neuroscience Section Abstract Doc Link 16361064 Disease Relevance 0.25 Pain Relevance 0.82
In conclusion, these data suggest that inhibition of GLAST expression in the spinal cord reduces excitatory synaptic activity and thereby spontaneous responses after nociceptive stimulation of the paw.
Negative_regulation (inhibition) of Gene_expression (expression) of GLAST in paw associated with nociception and spinal cord
3) Confidence 0.59 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16765320 Disease Relevance 0.81 Pain Relevance 0.55
Immunohistochemical studies show that the expression of both GLAST and GLT-1 in the L4-L5 spinal dorsal horn is decreased by 24% (P<0.001) and 23% (P<0.001), respectively, in rats with taxol-induced hyperalgesia as compared with those in control rats.
Negative_regulation (decreased) of Gene_expression (expression) of GLAST in spinal associated with hyperalgesia, spinal dorsal horn and taxol
4) Confidence 0.57 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15975716 Disease Relevance 0.33 Pain Relevance 0.88
Decreases in the expression of GLT-1 and GLAST were also found significant in a side to side comparison of the contralateral versus ipsilateral sides of the spinal cord within the PNSL animals (Figure 2E and Figure 3E).
Negative_regulation (Decreases) of Gene_expression (expression) of GLAST in spinal cord associated with spinal cord
5) Confidence 0.47 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.24 Pain Relevance 0.15
Similarly, the expression of GLAST was reduced by 54 ± 22.13% at 7 days and by 42 ± 16.34% at 14 days after nerve injury (Figure 3C, 3D, 3E).
Negative_regulation (reduced) of Gene_expression (expression) of GLAST in nerve associated with nervous system injury
6) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.31 Pain Relevance 0.18
Peripheral nerve injury [12,13] or chemotherapy [14] induced down-regulation of glutamate transporter protein expression and attenuation of glutamate uptake activity in the spinal dorsal horn.
Negative_regulation (regulation) of Gene_expression (expression) of glutamate transporter in spinal associated with glutamate, nervous system injury, spinal dorsal horn and peripheral nerve injury
7) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2713213 Disease Relevance 0.27 Pain Relevance 0.81
Down-regulation of glutamate transporter protein expression and attenuation of glutamate uptake activity in the spinal dorsal horn is associated with neuropathic pain induced by peripheral nerve injury [12,13,45] or by chemotherapy [14].
Negative_regulation (Down) of Gene_expression (expression) of glutamate transporter in dorsal horn associated with glutamate, nervous system injury, spinal dorsal horn, neuropathic pain and peripheral nerve injury
8) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2713213 Disease Relevance 0.90 Pain Relevance 1.14
Down-regulation of glutamate transporter protein expression and attenuation of glutamate uptake activity in the spinal dorsal horn is associated with neuropathic pain induced by peripheral nerve injury [12,13,45] or by chemotherapy [14].
Negative_regulation (regulation) of Gene_expression (expression) of glutamate transporter in dorsal horn associated with glutamate, nervous system injury, spinal dorsal horn, neuropathic pain and peripheral nerve injury
9) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2713213 Disease Relevance 0.90 Pain Relevance 1.14
GLAST protein expression was not altered after treatment of rats with either formalin or zymosan.
Neg (not) Negative_regulation (altered) of Gene_expression (expression) of GLAST
10) Confidence 0.37 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16765320 Disease Relevance 0.72 Pain Relevance 0.42
Characteristics of synaptically evoked glutamate transporter currents in spinal astrocytes
Negative_regulation (evoked) of Gene_expression (currents) of glutamate transporter in spinal associated with glutamate
11) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2713213 Disease Relevance 0 Pain Relevance 0.16
Chronic constriction nerve injury upregulated glutamate transporter expression at day 1 and 4 postoperatively, but it downregulated glutamate transporter expression at days 7 and 14 postoperatively [21].
Negative_regulation (downregulated) of Gene_expression (expression) of glutamate transporter in nerve associated with glutamate and nervous system injury
12) Confidence 0.35 Published 2005 Journal Mol Pain Section Body Doc Link PMC1274343 Disease Relevance 0.65 Pain Relevance 1.14
After PSNL, spinal glial cells show evidence of activation, the expression of GLT-1 and GLAST are decreased, and the decreases occur in the astrocytes.
Negative_regulation (decreased) of Gene_expression (expression) of GLAST in astrocytes
13) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.13 Pain Relevance 0.21
Expression and distribution of glutamate transporter in the spinal cord and dorsal root ganglion
Negative_regulation (distribution) of Gene_expression (Expression) of glutamate transporter in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, glutamate and spinal cord
14) Confidence 0.26 Published 2005 Journal Mol Pain Section Body Doc Link PMC1274343 Disease Relevance 1.08 Pain Relevance 1.47
In addition, concentrations of glutamate and aspartate were higher in baseline-P dialysates than in baseline-B dialysates, and the expression of the GTs (GLT-1, GLAST, and EAAC1) was downregulated by PTX treatment.
Negative_regulation (downregulated) of Gene_expression (expression) of GLAST associated with glutamate
15) Confidence 0.25 Published 2008 Journal Brain Res. Section Abstract Doc Link 18680732 Disease Relevance 0.13 Pain Relevance 1.32
Glutamate transporter inhibitors have recently been shown to produce antinociceptive effects in several preclinical pathological pain models.
Negative_regulation (inhibitors) of Gene_expression (produce) of Glutamate transporter associated with pain, glutamate and antinociceptive
16) Confidence 0.22 Published 2005 Journal Mol Pain Section Body Doc Link PMC1274343 Disease Relevance 1.09 Pain Relevance 1.77
Reduction of GLT-1 and/or GLAST expression and function has been reported in several neurodegenerative pathologies such as Alzheimer's disease [32], hippocampal sclerosis [33] and HD [34].
Negative_regulation (Reduction) of Gene_expression (expression) of GLAST associated with sclerosis, disease and neurodegenerative disease
17) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798716 Disease Relevance 0.72 Pain Relevance 0.34
We previously demonstrated that ultra-low dose naloxone restores the antinociceptive effect of morphine in rats with pertussis toxin (PTX)-induced thermal hyperalgesia by reversing the downregulation of glutamate transporter (GT) expression and suppressing spinal neuroinflammation.
Negative_regulation (downregulation) of Gene_expression (expression) of glutamate transporter in spinal associated with glutamate, bordatella infection, thermal hyperalgesia, narcan, antinociceptive and morphine
18) Confidence 0.17 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409222 Disease Relevance 0.36 Pain Relevance 0.70
Taken together, our findings provide evidence that GSE functions to regulate levels of proteins known to play important roles in regulating spinal neuronal and glial excitability by decreasing CGRP expression and increasing GLAST expression.
Negative_regulation (decreasing) of Gene_expression (expression) of GLAST in neuronal associated with calcitonin gene-related peptide
19) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.39 Pain Relevance 0.64
Expression and distribution of glutamate transporter in the spinal cord and dorsal root ganglion
Negative_regulation (distribution) of in spinal cord Gene_expression (Expression) of glutamate transporter in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, glutamate and spinal cord
20) Confidence 0.09 Published 2005 Journal Mol Pain Section Body Doc Link PMC1274343 Disease Relevance 1.08 Pain Relevance 1.47

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